Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Jan Budczies; Carsten Denkert; Berit M. Müller; Scarlet F. Brockmöller; Frederick Klauschen; Balasz Györffy; Manfred Dietel; Christiane Richter-Ehrenstein; Ulrike Marten; Reza M. Salek; Julian L. Griffin; Mika Hilvo; Matej Orešič; Gert Wohlgemuth; Oliver Fiehn

doi:10.1186/1471-2164-13-334

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Jan Budczies^*
, Carsten Denkert
, Berit M. Müller
, Scarlet F. Brockmöller
, Frederick Klauschen
, Balasz Györffy
, Manfred Dietel
, Christiane Richter-Ehrenstein
, Ulrike Marten
, Reza M. Salek
, Julian L. Griffin
, Mika Hilvo
, Matej Orešič
, Gert Wohlgemuth
, Oliver Fiehn

^*Corresponding author for this work

BA6308 Health data analytics

Charité Universitätsmedizin Berlin
Hungarian Academy of Sciences
DRK Kliniken Berlin
University of Cambridge
VTT (former employee or external)
University of California, Davis

Research output: Contribution to journal › Article › Scientific › peer-review

130 Citations (Scopus)

Abstract

Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

Original language	English
Article number	e334
Journal	BMC Genomics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1471-2164-13-334
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Metabolomics
Gas chromatography
Mass spectrometry
Cancer detection

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10.1186/1471-2164-13-334

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Budczies, J., Denkert, C., Müller, B. M., Brockmöller, S. F., Klauschen, F., Györffy, B., Dietel, M., Richter-Ehrenstein, C., Marten, U., Salek, R. M., Griffin, J. L., Hilvo, M., Orešič, M., Wohlgemuth, G., & Fiehn, O. (2012). Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study. BMC Genomics, 13(1), Article e334. https://doi.org/10.1186/1471-2164-13-334

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title = "Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study",

abstract = "Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.",

keywords = "Breast cancer, Metabolomics, Gas chromatography, Mass spectrometry, Cancer detection",

author = "Jan Budczies and Carsten Denkert and M{\"u}ller, \{Berit M.\} and Brockm{\"o}ller, \{Scarlet F.\} and Frederick Klauschen and Balasz Gy{\"o}rffy and Manfred Dietel and Christiane Richter-Ehrenstein and Ulrike Marten and Salek, \{Reza M.\} and Griffin, \{Julian L.\} and Mika Hilvo and Matej Ore{\v s}i{\v c} and Gert Wohlgemuth and Oliver Fiehn",

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volume = "13",

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Budczies, J, Denkert, C, Müller, BM, Brockmöller, SF, Klauschen, F, Györffy, B, Dietel, M, Richter-Ehrenstein, C, Marten, U, Salek, RM, Griffin, JL, Hilvo, M, Orešič, M, Wohlgemuth, G & Fiehn, O 2012, 'Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study', BMC Genomics, vol. 13, no. 1, e334. https://doi.org/10.1186/1471-2164-13-334

TY - JOUR

T1 - Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue

T2 - A GC-TOFMS based metabolomics study

AU - Budczies, Jan

AU - Denkert, Carsten

AU - Müller, Berit M.

AU - Brockmöller, Scarlet F.

AU - Klauschen, Frederick

AU - Györffy, Balasz

AU - Dietel, Manfred

AU - Richter-Ehrenstein, Christiane

AU - Marten, Ulrike

AU - Salek, Reza M.

AU - Griffin, Julian L.

AU - Hilvo, Mika

AU - Orešič, Matej

AU - Wohlgemuth, Gert

AU - Fiehn, Oliver

PY - 2012

Y1 - 2012

N2 - Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

AB - Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

KW - Breast cancer

KW - Metabolomics

KW - Gas chromatography

KW - Mass spectrometry

KW - Cancer detection

U2 - 10.1186/1471-2164-13-334

DO - 10.1186/1471-2164-13-334

M3 - Article

SN - 1471-2164

VL - 13

JO - BMC Genomics

JF - BMC Genomics

IS - 1

M1 - e334

ER -

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Abstract

UN SDGs

Keywords

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