Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Jan Budczies; Carsten Denkert; Berit M. Müller; Scarlet F. Brockmöller; Frederick Klauschen; Balasz Györffy; Manfred Dietel; Christiane Richter-Ehrenstein; Ulrike Marten; Reza M. Salek; Julian L. Griffin; Mika Hilvo; Matej Orešič; Gert Wohlgemuth; Oliver Fiehn

doi:10.1186/1471-2164-13-334

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Jan Budczies^*, Carsten Denkert, Berit M. Müller, Scarlet F. Brockmöller, Frederick Klauschen, Balasz Györffy, Manfred Dietel, Christiane Richter-Ehrenstein, Ulrike Marten, Reza M. Salek, Julian L. Griffin, Mika Hilvo, Matej Orešič, Gert Wohlgemuth, Oliver Fiehn

^*Corresponding author for this work

BA6308 Health data analytics

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Abstract

Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

Original language	English
Article number	e334
Journal	BMC Genomics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1471-2164-13-334
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

Keywords

Breast cancer
Metabolomics
Gas chromatography
Mass spectrometry
Cancer detection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1471-2164-13-334

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Budczies, J., Denkert, C., Müller, B. M., Brockmöller, S. F., Klauschen, F., Györffy, B., Dietel, M., Richter-Ehrenstein, C., Marten, U., Salek, R. M., Griffin, J. L., Hilvo, M., Orešič, M., Wohlgemuth, G., & Fiehn, O. (2012). Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study. BMC Genomics, 13(1), Article e334. https://doi.org/10.1186/1471-2164-13-334

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title = "Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study",

abstract = "Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.",

keywords = "Breast cancer, Metabolomics, Gas chromatography, Mass spectrometry, Cancer detection",

author = "Jan Budczies and Carsten Denkert and M{\"u}ller, \{Berit M.\} and Brockm{\"o}ller, \{Scarlet F.\} and Frederick Klauschen and Balasz Gy{\"o}rffy and Manfred Dietel and Christiane Richter-Ehrenstein and Ulrike Marten and Salek, \{Reza M.\} and Griffin, \{Julian L.\} and Mika Hilvo and Matej Ore{\v s}i{\v c} and Gert Wohlgemuth and Oliver Fiehn",

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volume = "13",

journal = "BMC Genomics",

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Budczies, J, Denkert, C, Müller, BM, Brockmöller, SF, Klauschen, F, Györffy, B, Dietel, M, Richter-Ehrenstein, C, Marten, U, Salek, RM, Griffin, JL, Hilvo, M, Orešič, M, Wohlgemuth, G & Fiehn, O 2012, 'Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study', BMC Genomics, vol. 13, no. 1, e334. https://doi.org/10.1186/1471-2164-13-334

TY - JOUR

T1 - Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue

T2 - A GC-TOFMS based metabolomics study

AU - Budczies, Jan

AU - Denkert, Carsten

AU - Müller, Berit M.

AU - Brockmöller, Scarlet F.

AU - Klauschen, Frederick

AU - Györffy, Balasz

AU - Dietel, Manfred

AU - Richter-Ehrenstein, Christiane

AU - Marten, Ulrike

AU - Salek, Reza M.

AU - Griffin, Julian L.

AU - Hilvo, Mika

AU - Orešič, Matej

AU - Wohlgemuth, Gert

AU - Fiehn, Oliver

PY - 2012

Y1 - 2012

N2 - Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

AB - Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

KW - Breast cancer

KW - Metabolomics

KW - Gas chromatography

KW - Mass spectrometry

KW - Cancer detection

U2 - 10.1186/1471-2164-13-334

DO - 10.1186/1471-2164-13-334

M3 - Article

SN - 1471-2164

VL - 13

JO - BMC Genomics

JF - BMC Genomics

IS - 1

M1 - e334

ER -

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Abstract

Keywords

UN SDGs

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