Retention in continuous two-dimensional thermal field-flow fractionation: Comparison of experimental results with theory

Pertti Vastamäki (Corresponding Author), P. Stephen Williams, Matti Jussila, Michel Martin, Marja-Liisa Riekkola

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

A theoretical and experimental study of continuous two-dimensional thermal field-flow fractionation (2D-ThFFF) is presented. Separation takes place in radial flow between two closely spaced discs, one of which is heated and the other cooled in order to maintain a temperature gradient across the channel. The cooled disc, which serves as the accumulation wall, is rotated relative to the other to create a shear component to the fluid flow. Under the influence of the thermal gradient and flow components, the sample components spiral outwards along different paths to the outer rim of the channel to be collected. The general principle of operation is described and an approximate theoretical model formulated for predicting the outlet position for the path of each sample component. Influence of the principal operational parameters, such as radial and angular flow rates and thermal gradient, on deflection angle of the sample trajectory are investigated. Fractionation is demonstrated for polystyrene polymer standards in a binary solvent consisting of cyclohexane and ethylbenzene. Experimental results are compared with theoretical predictions.
Original languageEnglish
Pages (from-to)116 - 127
JournalThe Analyst
Volume139
Issue number1
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Field Flow Fractionation
Fractionation
Thermal gradients
flow field
Flow fields
fractionation
Hot Temperature
radial flow
Theoretical Models
theoretical study
deflection
temperature gradient
fluid flow
Radial flow
Ethylbenzene
experimental study
polymer
Polystyrenes
trajectory
Cyclohexane

Keywords

  • field-flow fractionation
  • continuous fractionation
  • two-dimensional separation
  • thermal gradient
  • polystyrene
  • retention

Cite this

Vastamäki, Pertti ; Williams, P. Stephen ; Jussila, Matti ; Martin, Michel ; Riekkola, Marja-Liisa. / Retention in continuous two-dimensional thermal field-flow fractionation: Comparison of experimental results with theory. In: The Analyst. 2014 ; Vol. 139, No. 1. pp. 116 - 127.
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abstract = "A theoretical and experimental study of continuous two-dimensional thermal field-flow fractionation (2D-ThFFF) is presented. Separation takes place in radial flow between two closely spaced discs, one of which is heated and the other cooled in order to maintain a temperature gradient across the channel. The cooled disc, which serves as the accumulation wall, is rotated relative to the other to create a shear component to the fluid flow. Under the influence of the thermal gradient and flow components, the sample components spiral outwards along different paths to the outer rim of the channel to be collected. The general principle of operation is described and an approximate theoretical model formulated for predicting the outlet position for the path of each sample component. Influence of the principal operational parameters, such as radial and angular flow rates and thermal gradient, on deflection angle of the sample trajectory are investigated. Fractionation is demonstrated for polystyrene polymer standards in a binary solvent consisting of cyclohexane and ethylbenzene. Experimental results are compared with theoretical predictions.",
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Retention in continuous two-dimensional thermal field-flow fractionation: Comparison of experimental results with theory. / Vastamäki, Pertti (Corresponding Author); Williams, P. Stephen; Jussila, Matti; Martin, Michel; Riekkola, Marja-Liisa.

In: The Analyst, Vol. 139, No. 1, 2014, p. 116 - 127.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Retention in continuous two-dimensional thermal field-flow fractionation: Comparison of experimental results with theory

AU - Vastamäki, Pertti

AU - Williams, P. Stephen

AU - Jussila, Matti

AU - Martin, Michel

AU - Riekkola, Marja-Liisa

PY - 2014

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AB - A theoretical and experimental study of continuous two-dimensional thermal field-flow fractionation (2D-ThFFF) is presented. Separation takes place in radial flow between two closely spaced discs, one of which is heated and the other cooled in order to maintain a temperature gradient across the channel. The cooled disc, which serves as the accumulation wall, is rotated relative to the other to create a shear component to the fluid flow. Under the influence of the thermal gradient and flow components, the sample components spiral outwards along different paths to the outer rim of the channel to be collected. The general principle of operation is described and an approximate theoretical model formulated for predicting the outlet position for the path of each sample component. Influence of the principal operational parameters, such as radial and angular flow rates and thermal gradient, on deflection angle of the sample trajectory are investigated. Fractionation is demonstrated for polystyrene polymer standards in a binary solvent consisting of cyclohexane and ethylbenzene. Experimental results are compared with theoretical predictions.

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KW - continuous fractionation

KW - two-dimensional separation

KW - thermal gradient

KW - polystyrene

KW - retention

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