Role of ErbB4 in breast cancer

M. Sundvall, Kristiina Iljin, Sami Kilpinen, Henri Sara, Olli Kallioniemi, K. Elenius (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    88 Citations (Scopus)

    Abstract

    Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of normal mammary gland physiology, and aberrations in their signaling have been associated with breast tumorigenesis. Therapeutics targeting epidermal growth factor receptor (EGFR = ErbB1) or ErbB2 in breast cancer have been approved for clinical use. In contrast, relatively little is known about the biological significance of ErbB4 signaling in breast cancer. This review focuses on recent advances in our understanding about the role of ErbB4 in breast carcinogenesis, as well as in the potential clinical relevance of ErbB4 in breast cancer prognostics and therapy.
    Original languageEnglish
    Pages (from-to)259 - 268
    Number of pages10
    JournalJournal of Mammary Gland Biology and Neoplasia
    Volume13
    Issue number2
    DOIs
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Alternative splicing
    • Epidermal growth factor
    • Estrogen receptor
    • HER4
    • Neuregulins
    • Targeted therapeutics

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