Safety aspects of next generation probiotics

    Research output: Contribution to journalReview ArticleResearchpeer-review

    Abstract

    Advanced knowledge about the importance of gut microbiota for human health has increased the interest towards using new bacteria — besides the traditionally used lactobacilli and bifidobacteria — as probiotics. Currently candidates for next generation probiotics (NGP) have been searched amongst the gut bacteria that are associated with health, including strains from the genera Bacteroides, Clostridium, Faecalibacterium and Akkermansia. Unlike Lactobacillus spp. and Bifidobacterium spp., NGP, especially Bacteroides spp. and Clostridium spp., seem to be more ambivalent regarding their potential to cause infectious diseases. Therefore thorough safety assessment of NGP strains is vital. One important aspect of the safety assessment, which is sometimes ignored, is the potential to carry and spread antibiotic resistance genes. Because of the technological challenges in the production and formulation of many NGP species, it is likely that these will mainly be sold as supplements. The suitability and safety of novel probiotics to target consumer groups and conditions need to be carefully selected to ensure that the health promoting effects can be obtained.
    LanguageEnglish
    Pages8-13
    Number of pages6
    JournalCurrent Opinion in Food Science
    Volume30
    DOIs
    Publication statusAccepted/In press - 2019
    MoE publication typeNot Eligible

    Fingerprint

    Probiotics
    probiotics
    Safety
    Bacteroides
    Bifidobacterium
    safety assessment
    Clostridium
    Lactobacillus
    Health
    Bacteria
    health promotion
    bacteria
    Microbial Drug Resistance
    intestinal microorganisms
    antibiotic resistance
    infectious diseases
    Communicable Diseases
    human health
    digestive system
    Genes

    OKM Publication Types

    • A1 Refereed journal article

    OKM Open Access Status

    • 0 Not Open Access

    ASJC Scopus subject areas

    • Applied Microbiology and Biotechnology
    • Food Science

    Cite this

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    title = "Safety aspects of next generation probiotics",
    abstract = "Advanced knowledge about the importance of gut microbiota for human health has increased the interest towards using new bacteria — besides the traditionally used lactobacilli and bifidobacteria — as probiotics. Currently candidates for next generation probiotics (NGP) have been searched amongst the gut bacteria that are associated with health, including strains from the genera Bacteroides, Clostridium, Faecalibacterium and Akkermansia. Unlike Lactobacillus spp. and Bifidobacterium spp., NGP, especially Bacteroides spp. and Clostridium spp., seem to be more ambivalent regarding their potential to cause infectious diseases. Therefore thorough safety assessment of NGP strains is vital. One important aspect of the safety assessment, which is sometimes ignored, is the potential to carry and spread antibiotic resistance genes. Because of the technological challenges in the production and formulation of many NGP species, it is likely that these will mainly be sold as supplements. The suitability and safety of novel probiotics to target consumer groups and conditions need to be carefully selected to ensure that the health promoting effects can be obtained.",
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    language = "English",
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    Safety aspects of next generation probiotics. / Saarela, Maria.

    In: Current Opinion in Food Science, Vol. 30, 01.12.2019, p. 8-13.

    Research output: Contribution to journalReview ArticleResearchpeer-review

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    AB - Advanced knowledge about the importance of gut microbiota for human health has increased the interest towards using new bacteria — besides the traditionally used lactobacilli and bifidobacteria — as probiotics. Currently candidates for next generation probiotics (NGP) have been searched amongst the gut bacteria that are associated with health, including strains from the genera Bacteroides, Clostridium, Faecalibacterium and Akkermansia. Unlike Lactobacillus spp. and Bifidobacterium spp., NGP, especially Bacteroides spp. and Clostridium spp., seem to be more ambivalent regarding their potential to cause infectious diseases. Therefore thorough safety assessment of NGP strains is vital. One important aspect of the safety assessment, which is sometimes ignored, is the potential to carry and spread antibiotic resistance genes. Because of the technological challenges in the production and formulation of many NGP species, it is likely that these will mainly be sold as supplements. The suitability and safety of novel probiotics to target consumer groups and conditions need to be carefully selected to ensure that the health promoting effects can be obtained.

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