Artificial intelligence (AI) is a key technology that is utilized in autonomous systems. However, using AI in such systems introduces also several safety challenges, many of which are related to complex human-AI interactions. In general, these challenges relate to the changing roles of the people who interact with the increasingly autonomous systems in various ways. In this paper, we consider a set of practical safety challenges related to applying advanced AI to autonomous machine systems and present solutions from the perspective of human factors. We apply the novel concept of AI awareness (AIA) to discuss the challenges in detail, and based on this, provide suggestions and guidelines for mitigating the AI safety risks with autonomous systems. In addition, we briefly consider the system design process to identify the actions that should be taken to ensure AIA throughout the different systems engineering design phases. The theoretical research presented in this paper aims to provide the first steps towards considering AIA in autonomous systems and understanding the human factors perspective viewpoint on AI safety for autonomous systems.