SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

This paper introduces a portable rapid molecular diagnostics device concept based on unique and novel SAFTIR (Supercritical Angle Fluorescence and Total Internal Reflection) optical transducer technology. The device platform is compatible with numerous fluorescence assay chemistries for performing rapid tests on-site. The SAFTIR technology has been developed at VTT Technical Research Centre of Finland utilising our know-how in biosensors, integrated optics, electronics and biosensor prototyping. The uniqueness of the SAFTIR prototype device is based on the novel measurement principle involving integrated optical elements and waveguides on the disposable test strip and the specific reader device with proper interface optics. At concept level, SAFTIR has a lot of similarities with the Lateral Flow Assay (LFA) based rapid tests by consisting of an analyte specific disposable test strip and a special reader device. However, in technical details, there are significant differences and benefits, namely SAFTIR utilises surface-bound fluorescence detection principle ensuring high sensitivity with an excellent signal-to-noise ratio, fast response time and minimal sample matrix effects. In this paper, we present for the first time the integrated SAFTIR device concept, portable prototype and development aiming at smart farming applications. The initial application focus is on-site detection and quantitation of mycotoxins for both arable and livestock farming. The reference and starting point is a previously developed assay based on a recombinant anti-immunocomplex antibody for HT-2 mycotoxin detection.

Original languageEnglish
Title of host publicationPrecision Livestock Farming 2019
Subtitle of host publicationPapers Presented at the 9th European Conference on Precision Livestock Farming, ECPLF 2019
EditorsBernadette O'Brien, Deirdre Hennessy, Laurence Shalloo
Pages721-726
Publication statusPublished - 1 Jan 2019
MoE publication typeA4 Article in a conference publication
Event9th European Conference on Precision Livestock Farming, ECPLF 2019 - Cork, Ireland
Duration: 26 Aug 201929 Aug 2019

Conference

Conference9th European Conference on Precision Livestock Farming, ECPLF 2019
CountryIreland
CityCork
Period26/08/1929/08/19

Fingerprint

animal health
food safety
fluorescence
biosensors
optics
prototypes
mycotoxins
assays
farming systems
testing
electronics
Finland
chemistry
livestock
antibodies

Keywords

  • Fluorescence assay
  • HT-2
  • Molecular diagnostic
  • Mycotoxin
  • Rapid test

Cite this

Utriainen, M., Saviranta, P., Aikio, S., Hiltunen, M., Kokkonen, A., Mäyrä, A., ... Tappura, K. (2019). SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety. In B. O'Brien, D. Hennessy, & L. Shalloo (Eds.), Precision Livestock Farming 2019: Papers Presented at the 9th European Conference on Precision Livestock Farming, ECPLF 2019 (pp. 721-726)
Utriainen, Mikko ; Saviranta, Petri ; Aikio, Sanna ; Hiltunen, Marianne ; Kokkonen, Asko ; Mäyrä, Aki ; Alamäki, Markku ; Vasama, Hannu ; Tappura, Kirsi. / SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety. Precision Livestock Farming 2019: Papers Presented at the 9th European Conference on Precision Livestock Farming, ECPLF 2019. editor / Bernadette O'Brien ; Deirdre Hennessy ; Laurence Shalloo. 2019. pp. 721-726
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abstract = "This paper introduces a portable rapid molecular diagnostics device concept based on unique and novel SAFTIR (Supercritical Angle Fluorescence and Total Internal Reflection) optical transducer technology. The device platform is compatible with numerous fluorescence assay chemistries for performing rapid tests on-site. The SAFTIR technology has been developed at VTT Technical Research Centre of Finland utilising our know-how in biosensors, integrated optics, electronics and biosensor prototyping. The uniqueness of the SAFTIR prototype device is based on the novel measurement principle involving integrated optical elements and waveguides on the disposable test strip and the specific reader device with proper interface optics. At concept level, SAFTIR has a lot of similarities with the Lateral Flow Assay (LFA) based rapid tests by consisting of an analyte specific disposable test strip and a special reader device. However, in technical details, there are significant differences and benefits, namely SAFTIR utilises surface-bound fluorescence detection principle ensuring high sensitivity with an excellent signal-to-noise ratio, fast response time and minimal sample matrix effects. In this paper, we present for the first time the integrated SAFTIR device concept, portable prototype and development aiming at smart farming applications. The initial application focus is on-site detection and quantitation of mycotoxins for both arable and livestock farming. The reference and starting point is a previously developed assay based on a recombinant anti-immunocomplex antibody for HT-2 mycotoxin detection.",
keywords = "Fluorescence assay, HT-2, Molecular diagnostic, Mycotoxin, Rapid test",
author = "Mikko Utriainen and Petri Saviranta and Sanna Aikio and Marianne Hiltunen and Asko Kokkonen and Aki M{\"a}yr{\"a} and Markku Alam{\"a}ki and Hannu Vasama and Kirsi Tappura",
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Utriainen, M, Saviranta, P, Aikio, S, Hiltunen, M, Kokkonen, A, Mäyrä, A, Alamäki, M, Vasama, H & Tappura, K 2019, SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety. in B O'Brien, D Hennessy & L Shalloo (eds), Precision Livestock Farming 2019: Papers Presented at the 9th European Conference on Precision Livestock Farming, ECPLF 2019. pp. 721-726, 9th European Conference on Precision Livestock Farming, ECPLF 2019, Cork, Ireland, 26/08/19.

SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety. / Utriainen, Mikko (Corresponding author); Saviranta, Petri; Aikio, Sanna; Hiltunen, Marianne; Kokkonen, Asko; Mäyrä, Aki; Alamäki, Markku; Vasama, Hannu; Tappura, Kirsi.

Precision Livestock Farming 2019: Papers Presented at the 9th European Conference on Precision Livestock Farming, ECPLF 2019. ed. / Bernadette O'Brien; Deirdre Hennessy; Laurence Shalloo. 2019. p. 721-726.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

TY - GEN

T1 - SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety

AU - Utriainen, Mikko

AU - Saviranta, Petri

AU - Aikio, Sanna

AU - Hiltunen, Marianne

AU - Kokkonen, Asko

AU - Mäyrä, Aki

AU - Alamäki, Markku

AU - Vasama, Hannu

AU - Tappura, Kirsi

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N2 - This paper introduces a portable rapid molecular diagnostics device concept based on unique and novel SAFTIR (Supercritical Angle Fluorescence and Total Internal Reflection) optical transducer technology. The device platform is compatible with numerous fluorescence assay chemistries for performing rapid tests on-site. The SAFTIR technology has been developed at VTT Technical Research Centre of Finland utilising our know-how in biosensors, integrated optics, electronics and biosensor prototyping. The uniqueness of the SAFTIR prototype device is based on the novel measurement principle involving integrated optical elements and waveguides on the disposable test strip and the specific reader device with proper interface optics. At concept level, SAFTIR has a lot of similarities with the Lateral Flow Assay (LFA) based rapid tests by consisting of an analyte specific disposable test strip and a special reader device. However, in technical details, there are significant differences and benefits, namely SAFTIR utilises surface-bound fluorescence detection principle ensuring high sensitivity with an excellent signal-to-noise ratio, fast response time and minimal sample matrix effects. In this paper, we present for the first time the integrated SAFTIR device concept, portable prototype and development aiming at smart farming applications. The initial application focus is on-site detection and quantitation of mycotoxins for both arable and livestock farming. The reference and starting point is a previously developed assay based on a recombinant anti-immunocomplex antibody for HT-2 mycotoxin detection.

AB - This paper introduces a portable rapid molecular diagnostics device concept based on unique and novel SAFTIR (Supercritical Angle Fluorescence and Total Internal Reflection) optical transducer technology. The device platform is compatible with numerous fluorescence assay chemistries for performing rapid tests on-site. The SAFTIR technology has been developed at VTT Technical Research Centre of Finland utilising our know-how in biosensors, integrated optics, electronics and biosensor prototyping. The uniqueness of the SAFTIR prototype device is based on the novel measurement principle involving integrated optical elements and waveguides on the disposable test strip and the specific reader device with proper interface optics. At concept level, SAFTIR has a lot of similarities with the Lateral Flow Assay (LFA) based rapid tests by consisting of an analyte specific disposable test strip and a special reader device. However, in technical details, there are significant differences and benefits, namely SAFTIR utilises surface-bound fluorescence detection principle ensuring high sensitivity with an excellent signal-to-noise ratio, fast response time and minimal sample matrix effects. In this paper, we present for the first time the integrated SAFTIR device concept, portable prototype and development aiming at smart farming applications. The initial application focus is on-site detection and quantitation of mycotoxins for both arable and livestock farming. The reference and starting point is a previously developed assay based on a recombinant anti-immunocomplex antibody for HT-2 mycotoxin detection.

KW - Fluorescence assay

KW - HT-2

KW - Molecular diagnostic

KW - Mycotoxin

KW - Rapid test

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AN - SCOPUS:85073748666

SN - 978-1-8417-0654-2

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BT - Precision Livestock Farming 2019

A2 - O'Brien, Bernadette

A2 - Hennessy, Deirdre

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ER -

Utriainen M, Saviranta P, Aikio S, Hiltunen M, Kokkonen A, Mäyrä A et al. SAFTIR - a novel point-of-need diagnostic platform for animal health and food safety. In O'Brien B, Hennessy D, Shalloo L, editors, Precision Livestock Farming 2019: Papers Presented at the 9th European Conference on Precision Livestock Farming, ECPLF 2019. 2019. p. 721-726