Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection

John Jairo Aguilera-Correa, Sara Fernández-López, Iskra Dennisse Cuñas-Figueroa, Sandra Pérez-Rial, Hanna Leena Alakomi, Liisa Nohynek, Kirsi Marja Oksman-Caldentey, Juha Pekka Salminen, Jaime Esteban, Juan Cuadros, Riitta Puupponen-Pimiä (Corresponding Author), Ramon Perez-Tanoira, Teemu J. Kinnari (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

3 Downloads (Pure)

Abstract

Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity.

Original languageEnglish
Article number1481
Number of pages15
JournalAntibiotics
Volume10
Issue number12
DOIs
Publication statusPublished - 3 Dec 2021
MoE publication typeA1 Journal article-refereed

Keywords

  • Biofilm
  • Cloudberry
  • Ellagitannin
  • Methicillin-resistant S. aureus
  • Rubus

Fingerprint

Dive into the research topics of 'Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection'. Together they form a unique fingerprint.

Cite this