Secondary metabolites in the post-genomic era

Kirsi-Marja Oksman-Caldentey, Suvi T. Häkkinen, Alain Goossens, Into Laakso, Tuulikki Seppänen-Laakso, Anna-Maria Nuutila, Dirk Inze

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    Abstract

    Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.
    Original languageEnglish
    Title of host publicationPlant Biotechnology 2002 and Beyond
    EditorsIndra K. Vasil
    PublisherSpringer
    Pages465-468
    ISBN (Electronic)978-94-017-2679-5
    ISBN (Print)978-90-481-6220-8
    DOIs
    Publication statusPublished - 2003
    MoE publication typeNot Eligible
    Event10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond - Orlando, United States
    Duration: 23 Jun 200228 Jun 2002
    Conference number: 10

    Conference

    Conference10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond
    Country/TerritoryUnited States
    CityOrlando
    Period23/06/0228/06/02

    Keywords

    • secondary metabolite
    • amplify fragment length polymorphism
    • methyl jasmonate
    • plant cell culture
    • plant secondary metabolite

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