Secondary metabolites in the post-genomic era

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.
Original languageEnglish
Title of host publicationPlant Biotechnology 2002 and Beyond
EditorsIndra K. Vasil
PublisherSpringer
Pages465-468
ISBN (Electronic)978-94-017-2679-5
ISBN (Print)978-90-481-6220-8
DOIs
Publication statusPublished - 2003
MoE publication typeNot Eligible
Event10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond - Orlando, United States
Duration: 23 Jun 200228 Jun 2002
Conference number: 10

Conference

Conference10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond
CountryUnited States
CityOrlando
Period23/06/0228/06/02

Fingerprint

secondary metabolites
genomics
biochemical pathways
cell culture
methyl jasmonate
metabolomics
genetic engineering
engineers
proteomics
amplified fragment length polymorphism
alkaloids
production technology
tobacco
drugs
synthesis
genome
cells

Keywords

  • secondary metabolite
  • amplify fragment length polymorphism
  • methyl jasmonate
  • plant cell culture
  • plant secondary metabolite

Cite this

Oksman-Caldentey, K-M., Häkkinen, S. T., Goossens, A., Laakso, I., Seppänen-Laakso, T., Nuutila, A-M., & Inze, D. (2003). Secondary metabolites in the post-genomic era. In I. K. Vasil (Ed.), Plant Biotechnology 2002 and Beyond (pp. 465-468). Springer. https://doi.org/10.1007/978-94-017-2679-5_97
Oksman-Caldentey, Kirsi-Marja ; Häkkinen, Suvi T. ; Goossens, Alain ; Laakso, Into ; Seppänen-Laakso, Tuulikki ; Nuutila, Anna-Maria ; Inze, Dirk. / Secondary metabolites in the post-genomic era. Plant Biotechnology 2002 and Beyond. editor / Indra K. Vasil. Springer, 2003. pp. 465-468
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Oksman-Caldentey, K-M, Häkkinen, ST, Goossens, A, Laakso, I, Seppänen-Laakso, T, Nuutila, A-M & Inze, D 2003, Secondary metabolites in the post-genomic era. in IK Vasil (ed.), Plant Biotechnology 2002 and Beyond. Springer, pp. 465-468, 10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond, Orlando, United States, 23/06/02. https://doi.org/10.1007/978-94-017-2679-5_97

Secondary metabolites in the post-genomic era. / Oksman-Caldentey, Kirsi-Marja; Häkkinen, Suvi T.; Goossens, Alain; Laakso, Into; Seppänen-Laakso, Tuulikki; Nuutila, Anna-Maria; Inze, Dirk.

Plant Biotechnology 2002 and Beyond. ed. / Indra K. Vasil. Springer, 2003. p. 465-468.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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AU - Goossens, Alain

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AU - Seppänen-Laakso, Tuulikki

AU - Nuutila, Anna-Maria

AU - Inze, Dirk

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AB - Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.

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Oksman-Caldentey K-M, Häkkinen ST, Goossens A, Laakso I, Seppänen-Laakso T, Nuutila A-M et al. Secondary metabolites in the post-genomic era. In Vasil IK, editor, Plant Biotechnology 2002 and Beyond. Springer. 2003. p. 465-468 https://doi.org/10.1007/978-94-017-2679-5_97