Secondary metabolites in the post-genomic era

Kirsi-Marja Oksman-Caldentey; Suvi T. Häkkinen; Alain Goossens; Into Laakso; Tuulikki Seppänen-Laakso; Anna-Maria Nuutila; Dirk Inze

doi:10.1007/978-94-017-2679-5_97

Secondary metabolites in the post-genomic era

Kirsi-Marja Oksman-Caldentey, Suvi T. Häkkinen, Alain Goossens, Into Laakso, Tuulikki Seppänen-Laakso, Anna-Maria Nuutila, Dirk Inze

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

Abstract

Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.

Original language	English
Title of host publication	Plant Biotechnology 2002 and Beyond
Editors	Indra K. Vasil
Publisher	Springer
Pages	465-468
ISBN (Electronic)	978-94-017-2679-5
ISBN (Print)	978-90-481-6220-8
DOIs	https://doi.org/10.1007/978-94-017-2679-5_97
Publication status	Published - 2003
MoE publication type	Not Eligible
Event	10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond - Orlando, United States Duration: 23 Jun 2002 → 28 Jun 2002 Conference number: 10

Conference

Conference	10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond
Country/Territory	United States
City	Orlando
Period	23/06/02 → 28/06/02

Keywords

secondary metabolite
amplify fragment length polymorphism
methyl jasmonate
plant cell culture
plant secondary metabolite

Access to Document

10.1007/978-94-017-2679-5_97

Cite this

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title = "Secondary metabolites in the post-genomic era",

abstract = "Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.",

keywords = "secondary metabolite, amplify fragment length polymorphism, methyl jasmonate, plant cell culture, plant secondary metabolite",

author = "Kirsi-Marja Oksman-Caldentey and H{\"a}kkinen, \{Suvi T.\} and Alain Goossens and Into Laakso and Tuulikki Sepp{\"a}nen-Laakso and Anna-Maria Nuutila and Dirk Inze",

year = "2003",

doi = "10.1007/978-94-017-2679-5\_97",

language = "English",

isbn = "978-90-481-6220-8",

pages = "465--468",

editor = "Vasil, \{Indra K.\}",

booktitle = "Plant Biotechnology 2002 and Beyond",

publisher = "Springer",

address = "Germany",

note = "10th IAPTC\&B Congress Plant Biotechnology 2002 and Beyond ; Conference date: 23-06-2002 Through 28-06-2002",

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Oksman-Caldentey, K-M , Häkkinen, ST, Goossens, A, Laakso, I, Seppänen-Laakso, T, Nuutila, A-M & Inze, D 2003, Secondary metabolites in the post-genomic era. in IK Vasil (ed.), Plant Biotechnology 2002 and Beyond. Springer, pp. 465-468, 10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond, Orlando, Florida, United States, 23/06/02. https://doi.org/10.1007/978-94-017-2679-5_97

TY - GEN

T1 - Secondary metabolites in the post-genomic era

AU - Oksman-Caldentey, Kirsi-Marja

AU - Häkkinen, Suvi T.

AU - Goossens, Alain

AU - Laakso, Into

AU - Seppänen-Laakso, Tuulikki

AU - Nuutila, Anna-Maria

AU - Inze, Dirk

N1 - Conference code: 10

PY - 2003

Y1 - 2003

N2 - Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.

AB - Many important pharmaceutical compounds are still isolated from plants. Due to their complex structures the chemical synthesis of these secondary metabolites is usually not applied. Plant cell cultures would offer an attractive alternative production system. However, the yields in cell cultures have only in few cases been commercially feasible. Futhermore, due to the lack of understanding of the biosynthetic pathways, genetic engineering has not had much success until now. It is expected that the application of genomics, proteomics and metabolomics tools will create a paradigm shift in our ability to engineer the often complex biosynthetic pathways of plant secondary metabolites. To illustrate the power of this approach, we present some data on the genome-wide transcript cDNA-AFLP profiling in combination with a GC-MS-SIM alkaloid analysis of methyl jasmonate elicited BY-2 tobacco cells used as a model system.

KW - secondary metabolite

KW - amplify fragment length polymorphism

KW - methyl jasmonate

KW - plant cell culture

KW - plant secondary metabolite

U2 - 10.1007/978-94-017-2679-5_97

DO - 10.1007/978-94-017-2679-5_97

M3 - Conference article in proceedings

SN - 978-90-481-6220-8

SP - 465

EP - 468

BT - Plant Biotechnology 2002 and Beyond

A2 - Vasil, Indra K.

PB - Springer

T2 - 10th IAPTC&B Congress Plant Biotechnology 2002 and Beyond

Y2 - 23 June 2002 through 28 June 2002

ER -

Secondary metabolites in the post-genomic era

Abstract

Conference

Keywords

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