Secretion of secondary metabolites by ATP-binding cassette transporters in plant cell suspension cultures

Alain Goossens; Suvi T. Häkkinen; Into Laakso; Kirsi-Marja Oksman-Caldentey; Dirk Inzé

doi:10.1104/pp.102.016329

Secretion of secondary metabolites by ATP-binding cassette transporters in plant cell suspension cultures

Alain Goossens, Suvi T. Häkkinen, Into Laakso, Kirsi-Marja Oksman-Caldentey, Dirk Inzé

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Abstract

The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.

Original language	English
Pages (from-to)	1161-1164
Journal	Plant Physiology
Volume	131
Issue number	3
DOIs	https://doi.org/10.1104/pp.102.016329
Publication status	Published - 2003
MoE publication type	A1 Journal article-refereed

Keywords

metabolites
secondary metabolites
metabolomics
plant cells
ATP
gene expression
ABC transporters

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10.1104/pp.102.016329

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abstract = "The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.",

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AU - Goossens, Alain

AU - Häkkinen, Suvi T.

AU - Laakso, Into

AU - Oksman-Caldentey, Kirsi-Marja

AU - Inzé, Dirk

PY - 2003

Y1 - 2003

N2 - The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.

AB - The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.

KW - metabolites

KW - secondary metabolites

KW - metabolomics

KW - plant cells

KW - ATP

KW - gene expression

KW - ABC transporters

U2 - 10.1104/pp.102.016329

DO - 10.1104/pp.102.016329

M3 - Article

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SP - 1161

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JO - Plant Physiology

JF - Plant Physiology

IS - 3

ER -

Secretion of secondary metabolites by ATP-binding cassette transporters in plant cell suspension cultures

Abstract

Keywords

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