Secretion of secondary metabolites by ATP-binding cassette transporters in plant cell suspension cultures

Alain Goossens, Suvi T. Häkkinen, Into Laakso, Kirsi-Marja Oksman-Caldentey, Dirk Inzé

    Research output: Contribution to journalArticleScientificpeer-review

    52 Citations (Scopus)

    Abstract

    The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.
    Original languageEnglish
    Pages (from-to)1161-1164
    JournalPlant Physiology
    Volume131
    Issue number3
    DOIs
    Publication statusPublished - 2003
    MoE publication typeA1 Journal article-refereed

    Keywords

    • metabolites
    • secondary metabolites
    • metabolomics
    • plant cells
    • ATP
    • gene expression
    • ABC transporters

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