Secretion of secondary metabolites by ATP-binding cassette transporters in plant cell suspension cultures

Alain Goossens, Suvi T. Häkkinen, Into Laakso, Kirsi-Marja Oksman-Caldentey, Dirk Inzé

Research output: Contribution to journalArticleScientificpeer-review

51 Citations (Scopus)

Abstract

The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.
Original languageEnglish
Pages (from-to)1161-1164
JournalPlant Physiology
Volume131
Issue number3
DOIs
Publication statusPublished - 2003
MoE publication typeA1 Journal article-refereed

Keywords

  • metabolites
  • secondary metabolites
  • metabolomics
  • plant cells
  • ATP
  • gene expression
  • ABC transporters

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