Abstract
The substrate specificity of the yeast (Saccharomyces cerevisiae) pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporters is extended to plant secondary metabolites of the tropane alkaloid family. Functional analysis of yeast PDR5 genes in transgenic tobacco (Nicotiana tabacum L. cv Bright-Yellow 2 [BY-2]) cell lines suggest that PDR genes can be used to stimulate the secretion of secondary metabolites in plant cell suspension cultures.
| Original language | English |
|---|---|
| Pages (from-to) | 1161-1164 |
| Journal | Plant Physiology |
| Volume | 131 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2003 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- metabolites
- secondary metabolites
- metabolomics
- plant cells
- ATP
- gene expression
- ABC transporters
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