Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release

Sami Nummelin, Ville Liljeström, Eve Saarikoski, Jarmo Ropponen, Antti Nykänen, Veikko Linko, Jukka Seppälä, Jouni Hirvonen, Olli Ikkala, Luis M. Bimbo (Corresponding Author), Mauri A. Kostiainen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Abstract

Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt?%) to create supramolecular hydrogels (G'»G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.
Original languageEnglish
Pages (from-to)14433-14439
JournalChemistry - A European Journal
Volume21
Issue number41
DOIs
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

Fingerprint

Dendrimers
Hydrogels
Self assembly
Gels
Pharmaceutical Preparations
Hydrogel
X ray scattering
Drug delivery
Cryogenics
Peptides
Melting point
Materials properties
Ethanol
Enzymes
Elastic moduli
Molecular weight
Transmission electron microscopy
Mechanical properties
Scanning electron microscopy
Molecules

Keywords

  • amphiphiles
  • dendrimers
  • drug delivery
  • rheology
  • supramolecular gels

Cite this

Nummelin, Sami ; Liljeström, Ville ; Saarikoski, Eve ; Ropponen, Jarmo ; Nykänen, Antti ; Linko, Veikko ; Seppälä, Jukka ; Hirvonen, Jouni ; Ikkala, Olli ; Bimbo, Luis M. ; Kostiainen, Mauri A. / Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release. In: Chemistry - A European Journal. 2015 ; Vol. 21, No. 41. pp. 14433-14439.
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abstract = "Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt?{\%}) to create supramolecular hydrogels (G'»G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.",
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author = "Sami Nummelin and Ville Liljestr{\"o}m and Eve Saarikoski and Jarmo Ropponen and Antti Nyk{\"a}nen and Veikko Linko and Jukka Sepp{\"a}l{\"a} and Jouni Hirvonen and Olli Ikkala and Bimbo, {Luis M.} and Kostiainen, {Mauri A.}",
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Nummelin, S, Liljeström, V, Saarikoski, E, Ropponen, J, Nykänen, A, Linko, V, Seppälä, J, Hirvonen, J, Ikkala, O, Bimbo, LM & Kostiainen, MA 2015, 'Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release', Chemistry - A European Journal, vol. 21, no. 41, pp. 14433-14439. https://doi.org/10.1002/chem.201501812

Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release. / Nummelin, Sami; Liljeström, Ville; Saarikoski, Eve; Ropponen, Jarmo; Nykänen, Antti; Linko, Veikko; Seppälä, Jukka; Hirvonen, Jouni; Ikkala, Olli; Bimbo, Luis M. (Corresponding Author); Kostiainen, Mauri A. (Corresponding Author).

In: Chemistry - A European Journal, Vol. 21, No. 41, 2015, p. 14433-14439.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release

AU - Nummelin, Sami

AU - Liljeström, Ville

AU - Saarikoski, Eve

AU - Ropponen, Jarmo

AU - Nykänen, Antti

AU - Linko, Veikko

AU - Seppälä, Jukka

AU - Hirvonen, Jouni

AU - Ikkala, Olli

AU - Bimbo, Luis M.

AU - Kostiainen, Mauri A.

PY - 2015

Y1 - 2015

N2 - Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt?%) to create supramolecular hydrogels (G'»G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.

AB - Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt?%) to create supramolecular hydrogels (G'»G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.

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KW - dendrimers

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KW - rheology

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M3 - Article

VL - 21

SP - 14433

EP - 14439

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

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ER -