Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations

M.Y. Kirillin, A.V. Priezzhev, Jukka Hast, Risto Myllylä

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    Abstract

    In various publications, the values of blood optical parameters reported or used by different authors dffer dramatically. The aim of the present work is to estimate by means of Monte Carlo simulation the effect of variations of some of these parameters on the signals measured by different light scattering techniques. The following techniques are considered. optical coherence tomography, time-of-flight measurements, goniophotometry, and spectrophotometry implementing the integrating spheres measurements. The base wavelength of 820 mn within the diagnostic window, which is frequently used when implementing the mentioned techniques was chosen for the simulations. It was shown that both scattering coefficient and anisotropy factor affect the output signals. which vary significantly in the considered ranges of the parameters values. The strongest variations are due to varying the anisotropy factor, while varying the scattering coefficient influences primarily the level of the signal, but preserves its shape.
    Original languageEnglish
    Title of host publicationOptical Diagnostics and Sensing VI
    PublisherInternational Society for Optics and Photonics SPIE
    Number of pages7
    ISBN (Print)0-8194-6136-9
    DOIs
    Publication statusPublished - 2006
    MoE publication typeA4 Article in a conference publication

    Publication series

    SeriesProceedings of SPIE
    Volume6094
    ISSN0277-786X

    Keywords

    • interferometry
    • fringe pattern analysis
    • time domain methods
    • biosensor

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