Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations

M.Y. Kirillin, A.V. Priezzhev, Jukka Hast, Risto Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

In various publications, the values of blood optical parameters reported or used by different authors dffer dramatically. The aim of the present work is to estimate by means of Monte Carlo simulation the effect of variations of some of these parameters on the signals measured by different light scattering techniques. The following techniques are considered. optical coherence tomography, time-of-flight measurements, goniophotometry, and spectrophotometry implementing the integrating spheres measurements. The base wavelength of 820 mn within the diagnostic window, which is frequently used when implementing the mentioned techniques was chosen for the simulations. It was shown that both scattering coefficient and anisotropy factor affect the output signals. which vary significantly in the considered ranges of the parameters values. The strongest variations are due to varying the anisotropy factor, while varying the scattering coefficient influences primarily the level of the signal, but preserves its shape.
Original languageEnglish
Title of host publicationOptical Diagnostics and Sensing VI
PublisherInternational Society for Optics and Photonics SPIE
Number of pages7
ISBN (Print)0-8194-6136-9
DOIs
Publication statusPublished - 2006
MoE publication typeA4 Article in a conference publication

Publication series

SeriesProceedings of SPIE
Volume6094
ISSN0277-786X

Fingerprint

blood
light scattering
scattering coefficients
sensitivity
anisotropy
simulation
spectrophotometry
tomography
output
estimates
wavelengths

Keywords

  • interferometry
  • fringe pattern analysis
  • time domain methods
  • biosensor

Cite this

Kirillin, M. Y., Priezzhev, A. V., Hast, J., & Myllylä, R. (2006). Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations. In Optical Diagnostics and Sensing VI [60940O] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 6094 https://doi.org/10.1117/12.655001
Kirillin, M.Y. ; Priezzhev, A.V. ; Hast, Jukka ; Myllylä, Risto. / Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations. Optical Diagnostics and Sensing VI. International Society for Optics and Photonics SPIE, 2006. (Proceedings of SPIE, Vol. 6094).
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abstract = "In various publications, the values of blood optical parameters reported or used by different authors dffer dramatically. The aim of the present work is to estimate by means of Monte Carlo simulation the effect of variations of some of these parameters on the signals measured by different light scattering techniques. The following techniques are considered. optical coherence tomography, time-of-flight measurements, goniophotometry, and spectrophotometry implementing the integrating spheres measurements. The base wavelength of 820 mn within the diagnostic window, which is frequently used when implementing the mentioned techniques was chosen for the simulations. It was shown that both scattering coefficient and anisotropy factor affect the output signals. which vary significantly in the considered ranges of the parameters values. The strongest variations are due to varying the anisotropy factor, while varying the scattering coefficient influences primarily the level of the signal, but preserves its shape.",
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Kirillin, MY, Priezzhev, AV, Hast, J & Myllylä, R 2006, Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations. in Optical Diagnostics and Sensing VI., 60940O, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 6094. https://doi.org/10.1117/12.655001

Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations. / Kirillin, M.Y.; Priezzhev, A.V.; Hast, Jukka; Myllylä, Risto.

Optical Diagnostics and Sensing VI. International Society for Optics and Photonics SPIE, 2006. 60940O (Proceedings of SPIE, Vol. 6094).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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AB - In various publications, the values of blood optical parameters reported or used by different authors dffer dramatically. The aim of the present work is to estimate by means of Monte Carlo simulation the effect of variations of some of these parameters on the signals measured by different light scattering techniques. The following techniques are considered. optical coherence tomography, time-of-flight measurements, goniophotometry, and spectrophotometry implementing the integrating spheres measurements. The base wavelength of 820 mn within the diagnostic window, which is frequently used when implementing the mentioned techniques was chosen for the simulations. It was shown that both scattering coefficient and anisotropy factor affect the output signals. which vary significantly in the considered ranges of the parameters values. The strongest variations are due to varying the anisotropy factor, while varying the scattering coefficient influences primarily the level of the signal, but preserves its shape.

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Kirillin MY, Priezzhev AV, Hast J, Myllylä R. Sensitivity of different light scattering techniques to variations of optical parameters of a blood layer in vitro studied by Monte Carlo simulations. In Optical Diagnostics and Sensing VI. International Society for Optics and Photonics SPIE. 2006. 60940O. (Proceedings of SPIE, Vol. 6094). https://doi.org/10.1117/12.655001