Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 337-342 |
| Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
| Volume | 62 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2002 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- atherosclerosis
- coronary stenosis
- coronary heart disease
- inflammation
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Serum matrix metalloproteinase-9 concentration in angiographically assessed coronary artery disease. / Kalela, Anne; Koivu, Tommi; Sisto, T.; Kanervisto, J.; Höyhtyä, Matti; Sillanaukee, P.; Lehtimäki, T.; Nikkari, Seppo.
In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 62, No. 5, 2002, p. 337-342.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Serum matrix metalloproteinase-9 concentration in angiographically assessed coronary artery disease
AU - Kalela, Anne
AU - Koivu, Tommi
AU - Sisto, T.
AU - Kanervisto, J.
AU - Höyhtyä, Matti
AU - Sillanaukee, P.
AU - Lehtimäki, T.
AU - Nikkari, Seppo
PY - 2002
Y1 - 2002
N2 - Expression of several matrix metalloproteinases (MMPs) in atherosclerotic plaques has been well documented, and there are findings to indicate that arterial inflammation is reflected in increased serum concentration of matrix metalloproteinase-9 (MMP-9). In coronary atherosclerosis, there is enhanced expression of this MMP, which may be predictive of the severity of the disease. We determined the concentrations of serum MMP-9 in 61 patients (47 males, 14 females) who had >50% obstruction in one or more coronary arteries as assessed by coronary angiography before bypass surgery. In a control group of 19 patients (9 males, 10 females) there were no pathological findings in coronary angiography. ANOVA showed that serum MMP-9 concentrations were highest in patients with 3-vessel coronary artery disease (CAD) (57.3 - 39.1 µg/L, p= 0.011). The difference remained statistically significant after adjustment for age, diabetes and sex (p= 0.025, ANCOVA). When the groups were compared with each other, serum MMP-9 concentration was higher in the patients with 3-vessel CAD than in those with 1- or 2-vessel CAD (40.4 - 25.1 µg/L, p= 0.044) or in the controls (32.2 - 16.1 µg/L, p= 0.007). These results show that serum MMP-9 is elevated in patients with severe coronary stenosis compared with controls. Since MMP-9 has been suggested to reflect inflammation in atherosclerotic plaques, it may be useful in the evaluation of the severity of cardiovascular disease.
AB - Expression of several matrix metalloproteinases (MMPs) in atherosclerotic plaques has been well documented, and there are findings to indicate that arterial inflammation is reflected in increased serum concentration of matrix metalloproteinase-9 (MMP-9). In coronary atherosclerosis, there is enhanced expression of this MMP, which may be predictive of the severity of the disease. We determined the concentrations of serum MMP-9 in 61 patients (47 males, 14 females) who had >50% obstruction in one or more coronary arteries as assessed by coronary angiography before bypass surgery. In a control group of 19 patients (9 males, 10 females) there were no pathological findings in coronary angiography. ANOVA showed that serum MMP-9 concentrations were highest in patients with 3-vessel coronary artery disease (CAD) (57.3 - 39.1 µg/L, p= 0.011). The difference remained statistically significant after adjustment for age, diabetes and sex (p= 0.025, ANCOVA). When the groups were compared with each other, serum MMP-9 concentration was higher in the patients with 3-vessel CAD than in those with 1- or 2-vessel CAD (40.4 - 25.1 µg/L, p= 0.044) or in the controls (32.2 - 16.1 µg/L, p= 0.007). These results show that serum MMP-9 is elevated in patients with severe coronary stenosis compared with controls. Since MMP-9 has been suggested to reflect inflammation in atherosclerotic plaques, it may be useful in the evaluation of the severity of cardiovascular disease.
KW - atherosclerosis
KW - coronary stenosis
KW - coronary heart disease
KW - inflammation
U2 - 10.1080/00365510260296483
DO - 10.1080/00365510260296483
M3 - Article
VL - 62
SP - 337
EP - 342
JO - Scandinavian Journal of Clinical and Laboratory Investigation
JF - Scandinavian Journal of Clinical and Laboratory Investigation
SN - 0036-5513
IS - 5
ER -