Abstract
Elevated serum inflammatory markers have been reported in coronary heart
disease. Levels of serum matrix metalloproteinase‐9 (MMP‐9), C‐reactive
protein (CRP), C3‐complement (C3) and autoantibodies against oxidized
low‐density lipoprotein (oxLDL) in 120 male subjects with a history of
myocardial infarction (MI) were compared with those in 250 age‐matched
controls, both groups from a large cross‐sectional population survey,
the FINRISK study. The concentrations of serum MMP‐9 and autoantibodies
against oxLDL were measured by enzyme‐linked immunosorbent assay, CRP
and C3 by immunonephelometry. MMP‐9, CRP and C3 concentrations were
higher in the subjects with a history of MI than in the controls
(p=0.037, p=0.004, and p=0.006, respectively). There was no difference
between the groups in serum levels of autoantibodies against oxLDL. In
other background characteristics, men in the MI group had higher body
mass index (BMI) and serum triglyceride values and lower serum HDL
cholesterol values compared to controls (p=0.009, p=0.001, and
p<0.001, respectively). When analyzed by stepwise multiple logistic
regression using BMI, HDL cholesterol, triglycerides, CRP, C3 and MMP‐9
as independent variables, the significant predictors for MI were HDL
cholesterol (p=0.002) and MMP‐9 (p=0.015). These results suggest that
increased serum MMP‐9 may reflect inflammatory pathologic processes that
are related to progression of atherosclerosis.
Original language | English |
---|---|
Pages (from-to) | 255-261 |
Number of pages | 7 |
Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
Volume | 64 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2004 |
MoE publication type | A1 Journal article-refereed |
Keywords
- Aged
- Autoantibodies/blood
- Body Mass Index
- C-Reactive Protein/analysis
- Cholesterol/blood
- Cholesterol, HDL/blood
- Complement C3/analysis
- Cross-Sectional Studies
- Finland
- Humans
- Lipoproteins, LDL/immunology
- Logistic Models
- Male
- Matrix Metalloproteinase 9/blood
- Middle Aged
- Myocardial Infarction/blood
- Smoking
- Statistics, Nonparametric
- Triglycerides/blood