Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction

J. Renko, A. Kalela, O. Jaakkola, S. Laine, Matti Höyhtyä, H. Alho, S.T. Nikkari (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Elevated serum inflammatory markers have been reported in coronary heart disease. Levels of serum matrix metalloproteinase‐9 (MMP‐9), C‐reactive protein (CRP), C3‐complement (C3) and autoantibodies against oxidized low‐density lipoprotein (oxLDL) in 120 male subjects with a history of myocardial infarction (MI) were compared with those in 250 age‐matched controls, both groups from a large cross‐sectional population survey, the FINRISK study. The concentrations of serum MMP‐9 and autoantibodies against oxLDL were measured by enzyme‐linked immunosorbent assay, CRP and C3 by immunonephelometry. MMP‐9, CRP and C3 concentrations were higher in the subjects with a history of MI than in the controls (p=0.037, p=0.004, and p=0.006, respectively). There was no difference between the groups in serum levels of autoantibodies against oxLDL. In other background characteristics, men in the MI group had higher body mass index (BMI) and serum triglyceride values and lower serum HDL cholesterol values compared to controls (p=0.009, p=0.001, and p<0.001, respectively). When analyzed by stepwise multiple logistic regression using BMI, HDL cholesterol, triglycerides, CRP, C3 and MMP‐9 as independent variables, the significant predictors for MI were HDL cholesterol (p=0.002) and MMP‐9 (p=0.015). These results suggest that increased serum MMP‐9 may reflect inflammatory pathologic processes that are related to progression of atherosclerosis.
Original languageEnglish
Pages (from-to)255-261
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume64
Issue number3
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

Matrix Metalloproteinase 9
Myocardial Infarction
Autoantibodies
HDL Cholesterol
Lipoproteins
Serum
Triglycerides
Proteins
Immunosorbents
Body Mass Index
Logistics
Assays
Pathologic Processes
Coronary Disease
Atherosclerosis
Biomarkers
Logistic Models
Control Groups
Population

Keywords

  • biological markers
  • blood
  • coronary heart disease
  • gelatinase B/blood
  • male
  • risk factors

Cite this

Renko, J. ; Kalela, A. ; Jaakkola, O. ; Laine, S. ; Höyhtyä, Matti ; Alho, H. ; Nikkari, S.T. / Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction. In: Scandinavian Journal of Clinical and Laboratory Investigation. 2004 ; Vol. 64, No. 3. pp. 255-261.
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Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction. / Renko, J.; Kalela, A.; Jaakkola, O.; Laine, S.; Höyhtyä, Matti; Alho, H.; Nikkari, S.T. (Corresponding Author).

In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 64, No. 3, 2004, p. 255-261.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction

AU - Renko, J.

AU - Kalela, A.

AU - Jaakkola, O.

AU - Laine, S.

AU - Höyhtyä, Matti

AU - Alho, H.

AU - Nikkari, S.T.

PY - 2004

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N2 - Elevated serum inflammatory markers have been reported in coronary heart disease. Levels of serum matrix metalloproteinase‐9 (MMP‐9), C‐reactive protein (CRP), C3‐complement (C3) and autoantibodies against oxidized low‐density lipoprotein (oxLDL) in 120 male subjects with a history of myocardial infarction (MI) were compared with those in 250 age‐matched controls, both groups from a large cross‐sectional population survey, the FINRISK study. The concentrations of serum MMP‐9 and autoantibodies against oxLDL were measured by enzyme‐linked immunosorbent assay, CRP and C3 by immunonephelometry. MMP‐9, CRP and C3 concentrations were higher in the subjects with a history of MI than in the controls (p=0.037, p=0.004, and p=0.006, respectively). There was no difference between the groups in serum levels of autoantibodies against oxLDL. In other background characteristics, men in the MI group had higher body mass index (BMI) and serum triglyceride values and lower serum HDL cholesterol values compared to controls (p=0.009, p=0.001, and p<0.001, respectively). When analyzed by stepwise multiple logistic regression using BMI, HDL cholesterol, triglycerides, CRP, C3 and MMP‐9 as independent variables, the significant predictors for MI were HDL cholesterol (p=0.002) and MMP‐9 (p=0.015). These results suggest that increased serum MMP‐9 may reflect inflammatory pathologic processes that are related to progression of atherosclerosis.

AB - Elevated serum inflammatory markers have been reported in coronary heart disease. Levels of serum matrix metalloproteinase‐9 (MMP‐9), C‐reactive protein (CRP), C3‐complement (C3) and autoantibodies against oxidized low‐density lipoprotein (oxLDL) in 120 male subjects with a history of myocardial infarction (MI) were compared with those in 250 age‐matched controls, both groups from a large cross‐sectional population survey, the FINRISK study. The concentrations of serum MMP‐9 and autoantibodies against oxLDL were measured by enzyme‐linked immunosorbent assay, CRP and C3 by immunonephelometry. MMP‐9, CRP and C3 concentrations were higher in the subjects with a history of MI than in the controls (p=0.037, p=0.004, and p=0.006, respectively). There was no difference between the groups in serum levels of autoantibodies against oxLDL. In other background characteristics, men in the MI group had higher body mass index (BMI) and serum triglyceride values and lower serum HDL cholesterol values compared to controls (p=0.009, p=0.001, and p<0.001, respectively). When analyzed by stepwise multiple logistic regression using BMI, HDL cholesterol, triglycerides, CRP, C3 and MMP‐9 as independent variables, the significant predictors for MI were HDL cholesterol (p=0.002) and MMP‐9 (p=0.015). These results suggest that increased serum MMP‐9 may reflect inflammatory pathologic processes that are related to progression of atherosclerosis.

KW - biological markers

KW - blood

KW - coronary heart disease

KW - gelatinase B/blood

KW - male

KW - risk factors

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DO - 10.1080/00365510410006054

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JO - Scandinavian Journal of Clinical and Laboratory Investigation

JF - Scandinavian Journal of Clinical and Laboratory Investigation

SN - 0036-5513

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ER -