Shape variability of the human striatum: Effects of age and gender

Juha Koikkalainen (Corresponding Author), Jussi Hirvonen, Mikko Nyman, Jyrki Lötjönen, Jarmo Hietala, Ulla Ruotsalainen

Research output: Contribution to journalArticleScientificpeer-review

26 Citations (Scopus)

Abstract

Human striatum is involved in the regulation of movement, reinforcement, learning, reward, cognitive functioning, and addiction. Previous classical volumetric MRI studies have implicated age-, disease- and medication-related changes in striatal structures. Yet, no studies to date have addressed the effects of these factors on the shape variability and local structural alterations in the striatum. The local alterations may provide meaningful additional information in the context of functional neuroanatomy and brain connectivity. We developed image analysis methodology for the measurement of the volume and local shape variability of the human striatum. The method was applied in a group of 43 healthy controls to study the effects of age and gender on striatal shape variability. In the volume analysis, the volume of the striatum was normalized using the volume of the whole brain. In the local shape analysis, the deviations from a mean surface were studied for each surface point using high-dimensional mapping. Also, discriminant functions were constructed from a statistical shape model. The accuracy and reproducibility of the methods used were evaluated. The results confirmed that the volume of the striatum decreases as a function of age. However, the volume decrease was not uniform and age-related shape differences were observed in several subregions of the human striatum whereas no local gender differences were seen. Examination of the variability of striatal shape in the healthy population will pave the way for applying this method in clinical settings. This method will be particularly useful for investigating neuropsychiatric disorders that are associated with subtle morphological alterations of the brain, such as schizophrenia.
Original languageEnglish
Pages (from-to)85-93
JournalNeuroImage
Volume34
Issue number1
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Corpus Striatum
Brain
Neuroanatomy
Statistical Models
Reward
Schizophrenia
Learning
Population

Keywords

  • Striatum
  • Shape analysis
  • Volume analysis
  • PDM

Cite this

Koikkalainen, J., Hirvonen, J., Nyman, M., Lötjönen, J., Hietala, J., & Ruotsalainen, U. (2007). Shape variability of the human striatum: Effects of age and gender. NeuroImage, 34(1), 85-93. https://doi.org/10.1016/j.neuroimage.2006.08.039
Koikkalainen, Juha ; Hirvonen, Jussi ; Nyman, Mikko ; Lötjönen, Jyrki ; Hietala, Jarmo ; Ruotsalainen, Ulla. / Shape variability of the human striatum : Effects of age and gender. In: NeuroImage. 2007 ; Vol. 34, No. 1. pp. 85-93.
@article{087ce6a06e8245c88a26a362ba0436a7,
title = "Shape variability of the human striatum: Effects of age and gender",
abstract = "Human striatum is involved in the regulation of movement, reinforcement, learning, reward, cognitive functioning, and addiction. Previous classical volumetric MRI studies have implicated age-, disease- and medication-related changes in striatal structures. Yet, no studies to date have addressed the effects of these factors on the shape variability and local structural alterations in the striatum. The local alterations may provide meaningful additional information in the context of functional neuroanatomy and brain connectivity. We developed image analysis methodology for the measurement of the volume and local shape variability of the human striatum. The method was applied in a group of 43 healthy controls to study the effects of age and gender on striatal shape variability. In the volume analysis, the volume of the striatum was normalized using the volume of the whole brain. In the local shape analysis, the deviations from a mean surface were studied for each surface point using high-dimensional mapping. Also, discriminant functions were constructed from a statistical shape model. The accuracy and reproducibility of the methods used were evaluated. The results confirmed that the volume of the striatum decreases as a function of age. However, the volume decrease was not uniform and age-related shape differences were observed in several subregions of the human striatum whereas no local gender differences were seen. Examination of the variability of striatal shape in the healthy population will pave the way for applying this method in clinical settings. This method will be particularly useful for investigating neuropsychiatric disorders that are associated with subtle morphological alterations of the brain, such as schizophrenia.",
keywords = "Striatum, Shape analysis, Volume analysis, PDM",
author = "Juha Koikkalainen and Jussi Hirvonen and Mikko Nyman and Jyrki L{\"o}tj{\"o}nen and Jarmo Hietala and Ulla Ruotsalainen",
note = "Project code: 1271",
year = "2007",
doi = "10.1016/j.neuroimage.2006.08.039",
language = "English",
volume = "34",
pages = "85--93",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press",
number = "1",

}

Koikkalainen, J, Hirvonen, J, Nyman, M, Lötjönen, J, Hietala, J & Ruotsalainen, U 2007, 'Shape variability of the human striatum: Effects of age and gender', NeuroImage, vol. 34, no. 1, pp. 85-93. https://doi.org/10.1016/j.neuroimage.2006.08.039

Shape variability of the human striatum : Effects of age and gender. / Koikkalainen, Juha (Corresponding Author); Hirvonen, Jussi; Nyman, Mikko; Lötjönen, Jyrki; Hietala, Jarmo; Ruotsalainen, Ulla.

In: NeuroImage, Vol. 34, No. 1, 2007, p. 85-93.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Shape variability of the human striatum

T2 - Effects of age and gender

AU - Koikkalainen, Juha

AU - Hirvonen, Jussi

AU - Nyman, Mikko

AU - Lötjönen, Jyrki

AU - Hietala, Jarmo

AU - Ruotsalainen, Ulla

N1 - Project code: 1271

PY - 2007

Y1 - 2007

N2 - Human striatum is involved in the regulation of movement, reinforcement, learning, reward, cognitive functioning, and addiction. Previous classical volumetric MRI studies have implicated age-, disease- and medication-related changes in striatal structures. Yet, no studies to date have addressed the effects of these factors on the shape variability and local structural alterations in the striatum. The local alterations may provide meaningful additional information in the context of functional neuroanatomy and brain connectivity. We developed image analysis methodology for the measurement of the volume and local shape variability of the human striatum. The method was applied in a group of 43 healthy controls to study the effects of age and gender on striatal shape variability. In the volume analysis, the volume of the striatum was normalized using the volume of the whole brain. In the local shape analysis, the deviations from a mean surface were studied for each surface point using high-dimensional mapping. Also, discriminant functions were constructed from a statistical shape model. The accuracy and reproducibility of the methods used were evaluated. The results confirmed that the volume of the striatum decreases as a function of age. However, the volume decrease was not uniform and age-related shape differences were observed in several subregions of the human striatum whereas no local gender differences were seen. Examination of the variability of striatal shape in the healthy population will pave the way for applying this method in clinical settings. This method will be particularly useful for investigating neuropsychiatric disorders that are associated with subtle morphological alterations of the brain, such as schizophrenia.

AB - Human striatum is involved in the regulation of movement, reinforcement, learning, reward, cognitive functioning, and addiction. Previous classical volumetric MRI studies have implicated age-, disease- and medication-related changes in striatal structures. Yet, no studies to date have addressed the effects of these factors on the shape variability and local structural alterations in the striatum. The local alterations may provide meaningful additional information in the context of functional neuroanatomy and brain connectivity. We developed image analysis methodology for the measurement of the volume and local shape variability of the human striatum. The method was applied in a group of 43 healthy controls to study the effects of age and gender on striatal shape variability. In the volume analysis, the volume of the striatum was normalized using the volume of the whole brain. In the local shape analysis, the deviations from a mean surface were studied for each surface point using high-dimensional mapping. Also, discriminant functions were constructed from a statistical shape model. The accuracy and reproducibility of the methods used were evaluated. The results confirmed that the volume of the striatum decreases as a function of age. However, the volume decrease was not uniform and age-related shape differences were observed in several subregions of the human striatum whereas no local gender differences were seen. Examination of the variability of striatal shape in the healthy population will pave the way for applying this method in clinical settings. This method will be particularly useful for investigating neuropsychiatric disorders that are associated with subtle morphological alterations of the brain, such as schizophrenia.

KW - Striatum

KW - Shape analysis

KW - Volume analysis

KW - PDM

U2 - 10.1016/j.neuroimage.2006.08.039

DO - 10.1016/j.neuroimage.2006.08.039

M3 - Article

VL - 34

SP - 85

EP - 93

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

ER -

Koikkalainen J, Hirvonen J, Nyman M, Lötjönen J, Hietala J, Ruotsalainen U. Shape variability of the human striatum: Effects of age and gender. NeuroImage. 2007;34(1):85-93. https://doi.org/10.1016/j.neuroimage.2006.08.039