Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects

Reijo Takalo (Corresponding Author), Ilkka Korhonen, Väinö Turjanmaa, Silja Majahalme, Martti Tuomisto, Arto Uusitalo

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Abstract

Electrocardiogram and intra-arterial blood pressure were recorded in 96 men (aged 35 to 45 years) by the Oxford method over a 30-hour period. The study involved 33 normotensive, 29 borderline hypertensive, and 34 mildly hypertensive individuals, as assessed by the cuff method. Five-minute periods during sleep and with subjects in supine, sitting, and standing positions were extracted from the recordings for frequency domain analysis. Power spectrum density estimates of systolic blood pressure, diastolic blood pressure, and heart rate were calculated by an autoregressive method over the bandwidths of 0.02 to 0.075 (low-frequency), 0.075 to 0.15 (midfrequency), and 0.15 to 0.35 Hz (high-frequency), attributable to thermoregulatory, baroreceptor, and respiratory activity. No significant intergroup differences were observed at nighttime, but in different body positions the borderline hypertensive subjects frequently had either greater low-frequency variability or smaller midfrequency variability than the other groups. In this respect, the power spectra for systolic and diastolic blood pressures provided better statistical differentiation between the groups than those for heart rate. Furthermore, the borderline hypertensive subjects exhibited attenuated night-day changes in the low-frequency band for all time series. The results suggest that in borderline hypertension the baroreceptor oscillations are shifted to lower frequencies, presumably reflecting altered function of the sympathetic nervous system. In conclusion, spectral analysis of blood pressure variability for controlled test situations made it possible to detect differences in the cardiovascular regulatory systems between normotensive, borderline hypertensive, and mildly hypertensive individuals.
Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalHypertension
Volume23
Issue number1
Publication statusPublished - 1994
MoE publication typeA1 Journal article-refereed

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Heart Rate
Blood Pressure
Pressoreceptors
Posture
Supine Position
Sympathetic Nervous System
Cardiovascular System
Arterial Pressure
Sleep
Electrocardiography
Hypertension

Cite this

Takalo, R., Korhonen, I., Turjanmaa, V., Majahalme, S., Tuomisto, M., & Uusitalo, A. (1994). Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects. Hypertension, 23(1), 18-24.
Takalo, Reijo ; Korhonen, Ilkka ; Turjanmaa, Väinö ; Majahalme, Silja ; Tuomisto, Martti ; Uusitalo, Arto. / Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects. In: Hypertension. 1994 ; Vol. 23, No. 1. pp. 18-24.
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abstract = "Electrocardiogram and intra-arterial blood pressure were recorded in 96 men (aged 35 to 45 years) by the Oxford method over a 30-hour period. The study involved 33 normotensive, 29 borderline hypertensive, and 34 mildly hypertensive individuals, as assessed by the cuff method. Five-minute periods during sleep and with subjects in supine, sitting, and standing positions were extracted from the recordings for frequency domain analysis. Power spectrum density estimates of systolic blood pressure, diastolic blood pressure, and heart rate were calculated by an autoregressive method over the bandwidths of 0.02 to 0.075 (low-frequency), 0.075 to 0.15 (midfrequency), and 0.15 to 0.35 Hz (high-frequency), attributable to thermoregulatory, baroreceptor, and respiratory activity. No significant intergroup differences were observed at nighttime, but in different body positions the borderline hypertensive subjects frequently had either greater low-frequency variability or smaller midfrequency variability than the other groups. In this respect, the power spectra for systolic and diastolic blood pressures provided better statistical differentiation between the groups than those for heart rate. Furthermore, the borderline hypertensive subjects exhibited attenuated night-day changes in the low-frequency band for all time series. The results suggest that in borderline hypertension the baroreceptor oscillations are shifted to lower frequencies, presumably reflecting altered function of the sympathetic nervous system. In conclusion, spectral analysis of blood pressure variability for controlled test situations made it possible to detect differences in the cardiovascular regulatory systems between normotensive, borderline hypertensive, and mildly hypertensive individuals.",
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Takalo, R, Korhonen, I, Turjanmaa, V, Majahalme, S, Tuomisto, M & Uusitalo, A 1994, 'Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects', Hypertension, vol. 23, no. 1, pp. 18-24.

Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects. / Takalo, Reijo (Corresponding Author); Korhonen, Ilkka; Turjanmaa, Väinö; Majahalme, Silja; Tuomisto, Martti; Uusitalo, Arto.

In: Hypertension, Vol. 23, No. 1, 1994, p. 18-24.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects

AU - Takalo, Reijo

AU - Korhonen, Ilkka

AU - Turjanmaa, Väinö

AU - Majahalme, Silja

AU - Tuomisto, Martti

AU - Uusitalo, Arto

N1 - Project code: TTE3312

PY - 1994

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N2 - Electrocardiogram and intra-arterial blood pressure were recorded in 96 men (aged 35 to 45 years) by the Oxford method over a 30-hour period. The study involved 33 normotensive, 29 borderline hypertensive, and 34 mildly hypertensive individuals, as assessed by the cuff method. Five-minute periods during sleep and with subjects in supine, sitting, and standing positions were extracted from the recordings for frequency domain analysis. Power spectrum density estimates of systolic blood pressure, diastolic blood pressure, and heart rate were calculated by an autoregressive method over the bandwidths of 0.02 to 0.075 (low-frequency), 0.075 to 0.15 (midfrequency), and 0.15 to 0.35 Hz (high-frequency), attributable to thermoregulatory, baroreceptor, and respiratory activity. No significant intergroup differences were observed at nighttime, but in different body positions the borderline hypertensive subjects frequently had either greater low-frequency variability or smaller midfrequency variability than the other groups. In this respect, the power spectra for systolic and diastolic blood pressures provided better statistical differentiation between the groups than those for heart rate. Furthermore, the borderline hypertensive subjects exhibited attenuated night-day changes in the low-frequency band for all time series. The results suggest that in borderline hypertension the baroreceptor oscillations are shifted to lower frequencies, presumably reflecting altered function of the sympathetic nervous system. In conclusion, spectral analysis of blood pressure variability for controlled test situations made it possible to detect differences in the cardiovascular regulatory systems between normotensive, borderline hypertensive, and mildly hypertensive individuals.

AB - Electrocardiogram and intra-arterial blood pressure were recorded in 96 men (aged 35 to 45 years) by the Oxford method over a 30-hour period. The study involved 33 normotensive, 29 borderline hypertensive, and 34 mildly hypertensive individuals, as assessed by the cuff method. Five-minute periods during sleep and with subjects in supine, sitting, and standing positions were extracted from the recordings for frequency domain analysis. Power spectrum density estimates of systolic blood pressure, diastolic blood pressure, and heart rate were calculated by an autoregressive method over the bandwidths of 0.02 to 0.075 (low-frequency), 0.075 to 0.15 (midfrequency), and 0.15 to 0.35 Hz (high-frequency), attributable to thermoregulatory, baroreceptor, and respiratory activity. No significant intergroup differences were observed at nighttime, but in different body positions the borderline hypertensive subjects frequently had either greater low-frequency variability or smaller midfrequency variability than the other groups. In this respect, the power spectra for systolic and diastolic blood pressures provided better statistical differentiation between the groups than those for heart rate. Furthermore, the borderline hypertensive subjects exhibited attenuated night-day changes in the low-frequency band for all time series. The results suggest that in borderline hypertension the baroreceptor oscillations are shifted to lower frequencies, presumably reflecting altered function of the sympathetic nervous system. In conclusion, spectral analysis of blood pressure variability for controlled test situations made it possible to detect differences in the cardiovascular regulatory systems between normotensive, borderline hypertensive, and mildly hypertensive individuals.

M3 - Article

VL - 23

SP - 18

EP - 24

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 1

ER -

Takalo R, Korhonen I, Turjanmaa V, Majahalme S, Tuomisto M, Uusitalo A. Short-term variability of blood pressure and heart rate in borderline and mildly hypertensive subjects. Hypertension. 1994;23(1):18-24.