Simultaneous synthesis and coating of salbutamol sulphate nanoparticles with l-leucine in the gas phase

Anne Lähde, Janne Raula, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)

Abstract

Salbutamol sulphate nanoparticles have been simultaneously prepared and coated with l-leucine in the gas phase. Three different ways of coating can be separated based on the operation temperatures used in an aerosol flow reactor. Below the temperature of l-leucine sublimation, formation of the l-leucine layer on the core particle surface takes place via diffusion of l-leucine molecules on the droplet surfaces during droplet drying. At intermediate temperatures, the extent of sublimation of l-leucine depends notably on the concentration, and thus partial evaporation was expected. The l-leucine coating was solely formed via vapor deposition at high reactor temperatures when complete sublimation of l-leucine was obtained. The geometric mean diameter of the core salbutamol particles was approximately 65 nm. In general, particle size increased with the addition of l-leucine. The size distribution remained the same or broadened when the coating layer of the particles was formed via surface diffusion whereas notable narrowing of the distribution was observed when the coating was formed via vapor deposition. Upon desublimation and heterogeneous nucleation on the surfaces of smooth, spherical core particles, l-leucine formed a discontinuous coating with leafy crystals a few nanometers in size.
Original languageEnglish
Pages (from-to)256-262
JournalInternational Journal of Pharmaceutics
Volume358
Issue number1-2
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Albuterol
Leucine
Nanoparticles
Sulfates
Gases
Sublimation
Temperature
Aerosols
Particle Size

Keywords

  • aerosols
  • coatings
  • L-Leucine
  • nanoparticles
  • pharmaceutical
  • physical vapor deposition
  • salbutamol sulphate

Cite this

Lähde, Anne ; Raula, Janne ; Kauppinen, Esko I. / Simultaneous synthesis and coating of salbutamol sulphate nanoparticles with l-leucine in the gas phase. In: International Journal of Pharmaceutics. 2008 ; Vol. 358, No. 1-2. pp. 256-262.
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abstract = "Salbutamol sulphate nanoparticles have been simultaneously prepared and coated with l-leucine in the gas phase. Three different ways of coating can be separated based on the operation temperatures used in an aerosol flow reactor. Below the temperature of l-leucine sublimation, formation of the l-leucine layer on the core particle surface takes place via diffusion of l-leucine molecules on the droplet surfaces during droplet drying. At intermediate temperatures, the extent of sublimation of l-leucine depends notably on the concentration, and thus partial evaporation was expected. The l-leucine coating was solely formed via vapor deposition at high reactor temperatures when complete sublimation of l-leucine was obtained. The geometric mean diameter of the core salbutamol particles was approximately 65 nm. In general, particle size increased with the addition of l-leucine. The size distribution remained the same or broadened when the coating layer of the particles was formed via surface diffusion whereas notable narrowing of the distribution was observed when the coating was formed via vapor deposition. Upon desublimation and heterogeneous nucleation on the surfaces of smooth, spherical core particles, l-leucine formed a discontinuous coating with leafy crystals a few nanometers in size.",
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Simultaneous synthesis and coating of salbutamol sulphate nanoparticles with l-leucine in the gas phase. / Lähde, Anne; Raula, Janne; Kauppinen, Esko I. (Corresponding Author).

In: International Journal of Pharmaceutics, Vol. 358, No. 1-2, 2008, p. 256-262.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Simultaneous synthesis and coating of salbutamol sulphate nanoparticles with l-leucine in the gas phase

AU - Lähde, Anne

AU - Raula, Janne

AU - Kauppinen, Esko I.

PY - 2008

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N2 - Salbutamol sulphate nanoparticles have been simultaneously prepared and coated with l-leucine in the gas phase. Three different ways of coating can be separated based on the operation temperatures used in an aerosol flow reactor. Below the temperature of l-leucine sublimation, formation of the l-leucine layer on the core particle surface takes place via diffusion of l-leucine molecules on the droplet surfaces during droplet drying. At intermediate temperatures, the extent of sublimation of l-leucine depends notably on the concentration, and thus partial evaporation was expected. The l-leucine coating was solely formed via vapor deposition at high reactor temperatures when complete sublimation of l-leucine was obtained. The geometric mean diameter of the core salbutamol particles was approximately 65 nm. In general, particle size increased with the addition of l-leucine. The size distribution remained the same or broadened when the coating layer of the particles was formed via surface diffusion whereas notable narrowing of the distribution was observed when the coating was formed via vapor deposition. Upon desublimation and heterogeneous nucleation on the surfaces of smooth, spherical core particles, l-leucine formed a discontinuous coating with leafy crystals a few nanometers in size.

AB - Salbutamol sulphate nanoparticles have been simultaneously prepared and coated with l-leucine in the gas phase. Three different ways of coating can be separated based on the operation temperatures used in an aerosol flow reactor. Below the temperature of l-leucine sublimation, formation of the l-leucine layer on the core particle surface takes place via diffusion of l-leucine molecules on the droplet surfaces during droplet drying. At intermediate temperatures, the extent of sublimation of l-leucine depends notably on the concentration, and thus partial evaporation was expected. The l-leucine coating was solely formed via vapor deposition at high reactor temperatures when complete sublimation of l-leucine was obtained. The geometric mean diameter of the core salbutamol particles was approximately 65 nm. In general, particle size increased with the addition of l-leucine. The size distribution remained the same or broadened when the coating layer of the particles was formed via surface diffusion whereas notable narrowing of the distribution was observed when the coating was formed via vapor deposition. Upon desublimation and heterogeneous nucleation on the surfaces of smooth, spherical core particles, l-leucine formed a discontinuous coating with leafy crystals a few nanometers in size.

KW - aerosols

KW - coatings

KW - L-Leucine

KW - nanoparticles

KW - pharmaceutical

KW - physical vapor deposition

KW - salbutamol sulphate

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