Small non-coding RNAs mount a silent revolution in gene expression

Antti P Aalto, Amy E Pasquinelli

Research output: Contribution to journalReview Articlepeer-review

90 Citations (Scopus)


During the past decade, it has become evident that small non-coding RNAs (ncRNAs) participate in widespread and essential regulatory mechanisms in most eukaryotic cells. Novel classes of small RNAs, their biogenesis pathways and cellular effects are continuously being described, and new properties of already established ncRNAs are still being discovered. As the list of small RNA molecules and their roles becomes more and more extensive, one can get lost in the midst of new information. In this review, we attempt to bring order to the small ncRNA transcriptome by covering some of the major milestones of recent years. We go through many of the new properties that have been attributed to already familiar RNA molecules, and introduce some of the more recent novel classes of tiny ncRNAs.

Original languageEnglish
Pages (from-to)333-40
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number3
Publication statusPublished - Jun 2012
MoE publication typeA2 Review article in a scientific journal


  • Gene Expression
  • Gene Expression Regulation
  • Humans
  • MicroRNAs
  • RNA, Small Untranslated/genetics
  • Transcriptome


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