Smart nanotubes for bioseparations and biocatalysis

David Mitchell, Sang Bok Lee, Lacramioara Trofin, Naichao Li, Tarja Nevanen, Hans Söderlund, Charles Martin (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

541 Citations (Scopus)

Abstract

Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations.
For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.
Original languageEnglish
Pages (from-to)11864-11865
JournalJournal of the American Chemical Society
Volume124
Issue number40
DOIs
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed

Fingerprint

Biocatalysis
Nanotubes
Antibodies
Enantiomers
Enzymes
Enzyme immobilization
Glucose Oxidase
Detoxification
Glucose oxidase
Biocatalysts
Nanostructures
Bioreactors
Drug delivery
Silicon Dioxide
Immobilization
Pharmaceutical Preparations
Glucose
Silica
Oxidation
Molecules

Keywords

  • nanotubes

Cite this

Mitchell, D., Lee, S. B., Trofin, L., Li, N., Nevanen, T., Söderlund, H., & Martin, C. (2002). Smart nanotubes for bioseparations and biocatalysis. Journal of the American Chemical Society, 124(40), 11864-11865. https://doi.org/10.1021/ja027247b
Mitchell, David ; Lee, Sang Bok ; Trofin, Lacramioara ; Li, Naichao ; Nevanen, Tarja ; Söderlund, Hans ; Martin, Charles. / Smart nanotubes for bioseparations and biocatalysis. In: Journal of the American Chemical Society. 2002 ; Vol. 124, No. 40. pp. 11864-11865.
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Mitchell, D, Lee, SB, Trofin, L, Li, N, Nevanen, T, Söderlund, H & Martin, C 2002, 'Smart nanotubes for bioseparations and biocatalysis', Journal of the American Chemical Society, vol. 124, no. 40, pp. 11864-11865. https://doi.org/10.1021/ja027247b

Smart nanotubes for bioseparations and biocatalysis. / Mitchell, David; Lee, Sang Bok; Trofin, Lacramioara; Li, Naichao; Nevanen, Tarja; Söderlund, Hans; Martin, Charles (Corresponding Author).

In: Journal of the American Chemical Society, Vol. 124, No. 40, 2002, p. 11864-11865.

Research output: Contribution to journalArticleScientificpeer-review

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AB - Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations. For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.

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