Smart nanotubes for bioseparations and biocatalysis

David Mitchell, Sang Bok Lee, Lacramioara Trofin, Naichao Li, Tarja Nevanen, Hans Söderlund, Charles Martin (Corresponding Author)

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547 Citations (Scopus)

Abstract

Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations.
For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.
Original languageEnglish
Pages (from-to)11864-11865
JournalJournal of the American Chemical Society
Volume124
Issue number40
DOIs
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed

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Keywords

  • nanotubes

Cite this

Mitchell, D., Lee, S. B., Trofin, L., Li, N., Nevanen, T., Söderlund, H., & Martin, C. (2002). Smart nanotubes for bioseparations and biocatalysis. Journal of the American Chemical Society, 124(40), 11864-11865. https://doi.org/10.1021/ja027247b