Smart nanotubes for bioseparations and biocatalysis

David Mitchell; Sang Bok Lee; Lacramioara Trofin; Naichao Li; Tarja Nevanen; Hans Söderlund; Charles Martin

doi:10.1021/ja027247b

Smart nanotubes for bioseparations and biocatalysis

David Mitchell, Sang Bok Lee, Lacramioara Trofin, Naichao Li, Tarja Nevanen, Hans Söderlund, Charles Martin (Corresponding Author)

University of Florida

Research output: Contribution to journal › Article › Scientific › peer-review

589 Citations (Scopus)

Abstract

Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations.
For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.

Original language	English
Pages (from-to)	11864-11865
Journal	Journal of the American Chemical Society
Volume	124
Issue number	40
DOIs	https://doi.org/10.1021/ja027247b
Publication status	Published - 2002
MoE publication type	A1 Journal article-refereed

Keywords

nanotubes

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10.1021/ja027247b

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abstract = "Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations. For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.",

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T1 - Smart nanotubes for bioseparations and biocatalysis

AU - Mitchell, David

AU - Lee, Sang Bok

AU - Trofin, Lacramioara

AU - Li, Naichao

AU - Nevanen, Tarja

AU - Söderlund, Hans

AU - Martin, Charles

PY - 2002

Y1 - 2002

N2 - Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations. For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.

AB - Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations. For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 40

ER -

Smart nanotubes for bioseparations and biocatalysis

Abstract

Keywords

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