Space efficient system for whole-body exposure of unrestrained rats to 900 MHz electromagnetic fields

Lauri Puranen (Corresponding Author), Tim Toivo, Tommi Toivonen, Risto Pitkäaho, Asko Turunen, Ari-Pekka Sihvonen, Kari Jokela, Päivi Heikkinen, Timo Kumlin, Jukka Juutilainen

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Abstract

The aim of this study was to design, implement and analyze a space‐efficient setup for the whole‐body exposure of unrestrained Wistar rats to radiofrequency (RF) electromagnetic fields at 900 MHz. The setup was used for 2 years in a cocarcinogenesis study and part of it for 5 weeks in a central nervous system (CNS) study. Up to 216 rats could be placed in separate cages in nine different exposure chambers on three racks requiring only 9 m2 of floor area (24 rats per m2). Chambers were radial transmission lines (RTL), where the rats could freely move in their cages where food and drinking water was provided ad libitum except during RF exposure periods. Dosimetrical analysis was based on FDTD computations with heterogeneous rat models and was validated with calorimetrical measurements carried out with homogeneous phantoms. The estimated whole‐body average specific absorption rates (SAR) of rats were 0 (sham), 0.4, and 1.3 W/kg in the cocarcinogenesis study and 0 (sham), 0.27, and 2.7 W/kg in the CNS study with an estimated uncertainty of 3 dB (K = 2). The instantaneous and lifetime variations of whole‐body average SAR due to the movement of rats were estimated to be 2.3 and 1.3 dB (K = 1), respectively.
Original languageEnglish
Pages (from-to)120-128
JournalBioelectromagnetics
Volume30
Issue number2
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fingerprint

Electromagnetic Fields
Cocarcinogenesis
Central Nervous System
Drinking Water
Uncertainty
Wistar Rats
Food

Keywords

  • RF exposure and dosimetry
  • GSM 900 MHz
  • unrestrained rats
  • SAR

Cite this

Puranen, L., Toivo, T., Toivonen, T., Pitkäaho, R., Turunen, A., Sihvonen, A-P., ... Juutilainen, J. (2009). Space efficient system for whole-body exposure of unrestrained rats to 900 MHz electromagnetic fields. Bioelectromagnetics, 30(2), 120-128. https://doi.org/10.1002/bem.20449
Puranen, Lauri ; Toivo, Tim ; Toivonen, Tommi ; Pitkäaho, Risto ; Turunen, Asko ; Sihvonen, Ari-Pekka ; Jokela, Kari ; Heikkinen, Päivi ; Kumlin, Timo ; Juutilainen, Jukka. / Space efficient system for whole-body exposure of unrestrained rats to 900 MHz electromagnetic fields. In: Bioelectromagnetics. 2009 ; Vol. 30, No. 2. pp. 120-128.
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abstract = "The aim of this study was to design, implement and analyze a space‐efficient setup for the whole‐body exposure of unrestrained Wistar rats to radiofrequency (RF) electromagnetic fields at 900 MHz. The setup was used for 2 years in a cocarcinogenesis study and part of it for 5 weeks in a central nervous system (CNS) study. Up to 216 rats could be placed in separate cages in nine different exposure chambers on three racks requiring only 9 m2 of floor area (24 rats per m2). Chambers were radial transmission lines (RTL), where the rats could freely move in their cages where food and drinking water was provided ad libitum except during RF exposure periods. Dosimetrical analysis was based on FDTD computations with heterogeneous rat models and was validated with calorimetrical measurements carried out with homogeneous phantoms. The estimated whole‐body average specific absorption rates (SAR) of rats were 0 (sham), 0.4, and 1.3 W/kg in the cocarcinogenesis study and 0 (sham), 0.27, and 2.7 W/kg in the CNS study with an estimated uncertainty of 3 dB (K = 2). The instantaneous and lifetime variations of whole‐body average SAR due to the movement of rats were estimated to be 2.3 and 1.3 dB (K = 1), respectively.",
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author = "Lauri Puranen and Tim Toivo and Tommi Toivonen and Risto Pitk{\"a}aho and Asko Turunen and Ari-Pekka Sihvonen and Kari Jokela and P{\"a}ivi Heikkinen and Timo Kumlin and Jukka Juutilainen",
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Puranen, L, Toivo, T, Toivonen, T, Pitkäaho, R, Turunen, A, Sihvonen, A-P, Jokela, K, Heikkinen, P, Kumlin, T & Juutilainen, J 2009, 'Space efficient system for whole-body exposure of unrestrained rats to 900 MHz electromagnetic fields', Bioelectromagnetics, vol. 30, no. 2, pp. 120-128. https://doi.org/10.1002/bem.20449

Space efficient system for whole-body exposure of unrestrained rats to 900 MHz electromagnetic fields. / Puranen, Lauri (Corresponding Author); Toivo, Tim; Toivonen, Tommi; Pitkäaho, Risto; Turunen, Asko; Sihvonen, Ari-Pekka; Jokela, Kari; Heikkinen, Päivi; Kumlin, Timo; Juutilainen, Jukka.

In: Bioelectromagnetics, Vol. 30, No. 2, 2009, p. 120-128.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Space efficient system for whole-body exposure of unrestrained rats to 900 MHz electromagnetic fields

AU - Puranen, Lauri

AU - Toivo, Tim

AU - Toivonen, Tommi

AU - Pitkäaho, Risto

AU - Turunen, Asko

AU - Sihvonen, Ari-Pekka

AU - Jokela, Kari

AU - Heikkinen, Päivi

AU - Kumlin, Timo

AU - Juutilainen, Jukka

PY - 2009

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N2 - The aim of this study was to design, implement and analyze a space‐efficient setup for the whole‐body exposure of unrestrained Wistar rats to radiofrequency (RF) electromagnetic fields at 900 MHz. The setup was used for 2 years in a cocarcinogenesis study and part of it for 5 weeks in a central nervous system (CNS) study. Up to 216 rats could be placed in separate cages in nine different exposure chambers on three racks requiring only 9 m2 of floor area (24 rats per m2). Chambers were radial transmission lines (RTL), where the rats could freely move in their cages where food and drinking water was provided ad libitum except during RF exposure periods. Dosimetrical analysis was based on FDTD computations with heterogeneous rat models and was validated with calorimetrical measurements carried out with homogeneous phantoms. The estimated whole‐body average specific absorption rates (SAR) of rats were 0 (sham), 0.4, and 1.3 W/kg in the cocarcinogenesis study and 0 (sham), 0.27, and 2.7 W/kg in the CNS study with an estimated uncertainty of 3 dB (K = 2). The instantaneous and lifetime variations of whole‐body average SAR due to the movement of rats were estimated to be 2.3 and 1.3 dB (K = 1), respectively.

AB - The aim of this study was to design, implement and analyze a space‐efficient setup for the whole‐body exposure of unrestrained Wistar rats to radiofrequency (RF) electromagnetic fields at 900 MHz. The setup was used for 2 years in a cocarcinogenesis study and part of it for 5 weeks in a central nervous system (CNS) study. Up to 216 rats could be placed in separate cages in nine different exposure chambers on three racks requiring only 9 m2 of floor area (24 rats per m2). Chambers were radial transmission lines (RTL), where the rats could freely move in their cages where food and drinking water was provided ad libitum except during RF exposure periods. Dosimetrical analysis was based on FDTD computations with heterogeneous rat models and was validated with calorimetrical measurements carried out with homogeneous phantoms. The estimated whole‐body average specific absorption rates (SAR) of rats were 0 (sham), 0.4, and 1.3 W/kg in the cocarcinogenesis study and 0 (sham), 0.27, and 2.7 W/kg in the CNS study with an estimated uncertainty of 3 dB (K = 2). The instantaneous and lifetime variations of whole‐body average SAR due to the movement of rats were estimated to be 2.3 and 1.3 dB (K = 1), respectively.

KW - RF exposure and dosimetry

KW - GSM 900 MHz

KW - unrestrained rats

KW - SAR

U2 - 10.1002/bem.20449

DO - 10.1002/bem.20449

M3 - Article

VL - 30

SP - 120

EP - 128

JO - Bioelectromagnetics

JF - Bioelectromagnetics

SN - 0197-8462

IS - 2

ER -