Abstract
Background and Goal of Study. Today no numeric measures
of nociception during general anaesthesia are available.
In search of such readily useable measure both predictive
characteristics of the drug effect and responses to
surgical stimulation are needed. We analyzed the
alterations of photoplethysmographic waveform amplitude
(PPGA) and heart rate (HR) during changing surgical
stimuli and different target site levels of remifentanil.
Our purpose was to develop a State Index of Nociception
(SN) based on PPGA and HR derived information, which
could measure the adequacy of analgesia during general
anaesthesia and surgery.
Materials and Methods. Physiological parameters were
measured from 53 female patients anaesthetized with
propofol and remifentanil, and paralysed with rocuronium.
Remifentanil target site concentration was adjusted to 1,
3, or 5 ng/ml during surgery. SN was used to explain the
combination of stimulation and remifentanil effect site
concentration. SN was correlated with stimulation and
remifentanil for each patient and the significance was
calculated using Wilcoxon sign rank test over the
subjects .
Results and Discussions. SN correlated positively with
stimulation (median r=0.42, P<0.0001) and negatively with
remifentanil level (median r=-0.33, P<0.0001). Median
correlation with their difference was 0.50 (P<0.0001).
High SN values indicated presence of noxious stimuli and
low remifentanil levels.
Conclusions. SN is sensitive to low analgesia levels
during noxious stimulation, and provides information of
the adequacy of anesthesia.
| Original language | English |
|---|---|
| Article number | A-111 |
| Pages (from-to) | 31 |
| Journal | European Journal of Anaesthesiology |
| Volume | 22 |
| Publication status | Published - 2005 |
| MoE publication type | B1 Article in a scientific magazine |
| Event | Annual Meeting of the European Society of Anaesthesiology (Euroanaesthesia2005). Vienna, Austria, 28 - 31 May 2005 - Duration: 1 Jan 2005 → … |