Abstract
| Original language | English |
|---|---|
| Article number | A-111 |
| Pages (from-to) | 31 |
| Journal | European Journal of Anaesthesiology |
| Volume | 22 |
| Publication status | Published - 2005 |
| MoE publication type | B1 Article in a scientific magazine |
| Event | Annual Meeting of the European Society of Anaesthesiology (Euroanaesthesia2005). Vienna, Austria, 28 - 31 May 2005 - Duration: 1 Jan 2005 → … |
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State index of nociception correlates both with remifentanil concentration and level of painful stimulation during surgery. / Yli-Hankala, Arvi; Rantanen, Markku; Korhonen, Ilkka; van Gils, Mark; Yppärilä-Wolters, Heidi; Huiku, Matti; Kymäläinen, Minna; Takala, Panu; Uutela, Kimmo; Viertiö-Oja, Hanna.
In: European Journal of Anaesthesiology, Vol. 22, A-111, 2005, p. 31.Research output: Contribution to journal › Other journal contribution › Scientific
TY - JOUR
T1 - State index of nociception correlates both with remifentanil concentration and level of painful stimulation during surgery
AU - Yli-Hankala, Arvi
AU - Rantanen, Markku
AU - Korhonen, Ilkka
AU - van Gils, Mark
AU - Yppärilä-Wolters, Heidi
AU - Huiku, Matti
AU - Kymäläinen, Minna
AU - Takala, Panu
AU - Uutela, Kimmo
AU - Viertiö-Oja, Hanna
N1 - CA2: TTE5 CA: TTE Project code: T5SU00454
PY - 2005
Y1 - 2005
N2 - Background and Goal of Study. Today no numeric measures of nociception during general anaesthesia are available. In search of such readily useable measure both predictive characteristics of the drug effect and responses to surgical stimulation are needed. We analyzed the alterations of photoplethysmographic waveform amplitude (PPGA) and heart rate (HR) during changing surgical stimuli and different target site levels of remifentanil. Our purpose was to develop a State Index of Nociception (SN) based on PPGA and HR derived information, which could measure the adequacy of analgesia during general anaesthesia and surgery. Materials and Methods. Physiological parameters were measured from 53 female patients anaesthetized with propofol and remifentanil, and paralysed with rocuronium. Remifentanil target site concentration was adjusted to 1, 3, or 5 ng/ml during surgery. SN was used to explain the combination of stimulation and remifentanil effect site concentration. SN was correlated with stimulation and remifentanil for each patient and the significance was calculated using Wilcoxon sign rank test over the subjects . Results and Discussions. SN correlated positively with stimulation (median r=0.42, P<0.0001) and negatively with remifentanil level (median r=-0.33, P<0.0001). Median correlation with their difference was 0.50 (P<0.0001). High SN values indicated presence of noxious stimuli and low remifentanil levels. Conclusions. SN is sensitive to low analgesia levels during noxious stimulation, and provides information of the adequacy of anesthesia.
AB - Background and Goal of Study. Today no numeric measures of nociception during general anaesthesia are available. In search of such readily useable measure both predictive characteristics of the drug effect and responses to surgical stimulation are needed. We analyzed the alterations of photoplethysmographic waveform amplitude (PPGA) and heart rate (HR) during changing surgical stimuli and different target site levels of remifentanil. Our purpose was to develop a State Index of Nociception (SN) based on PPGA and HR derived information, which could measure the adequacy of analgesia during general anaesthesia and surgery. Materials and Methods. Physiological parameters were measured from 53 female patients anaesthetized with propofol and remifentanil, and paralysed with rocuronium. Remifentanil target site concentration was adjusted to 1, 3, or 5 ng/ml during surgery. SN was used to explain the combination of stimulation and remifentanil effect site concentration. SN was correlated with stimulation and remifentanil for each patient and the significance was calculated using Wilcoxon sign rank test over the subjects . Results and Discussions. SN correlated positively with stimulation (median r=0.42, P<0.0001) and negatively with remifentanil level (median r=-0.33, P<0.0001). Median correlation with their difference was 0.50 (P<0.0001). High SN values indicated presence of noxious stimuli and low remifentanil levels. Conclusions. SN is sensitive to low analgesia levels during noxious stimulation, and provides information of the adequacy of anesthesia.
M3 - Other journal contribution
VL - 22
SP - 31
JO - European Journal of Anaesthesiology
JF - European Journal of Anaesthesiology
SN - 0265-0215
M1 - A-111
ER -