Stereospecific hydrolysis 3-(4-methoxyphenyl)glycidic ester in supercritical carbon dioxide by immobilized lipase

Markku Rantakylä, Martti Alkio, Olli Aaltonen

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

In the hydrolysis of racemic 3-(4-methoxyphenyl)glycidic acid methyl ester by immobilized Mucor miehel lipase in supercritical CO2 the initial hydrolysis rate of the (2S,3R)-form was faster than the rate of the (2R,3S) -form. The stereoisomeric excess of the (2R,3S)-form reached 87 % at 53 % total conversion level. The water content of the reaction mixture and the initial concentration of the 3-(4-methoxyphenyl) glycidic acid methyl ester had no effect on isomeric purity. The reaction rate in supercritical CO2 was considerably faster than in toluene/water -mixture.
Original languageEnglish
Pages (from-to)1089-1094
JournalBiotechnology Letters
Volume18
Issue number9
DOIs
Publication statusPublished - 1996
MoE publication typeA1 Journal article-refereed

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