Abstract
Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as d-xylose and l-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.
Original language | English |
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Article number | 147 |
Number of pages | 21 |
Journal | Biotechnology for Biofuels and Bioproducts |
Volume | 15 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Dec 2022 |
MoE publication type | A2 Review article in a scientific journal |
Funding
This work was supported by the Academy of Finland (Decision 322619).
Keywords
- Aldolase
- Aldopentose
- Aldose-1-dehydrogenase
- Ketoglutarate-semialdehyde dehydrogenase
- Lactonase
- Non-phosphorylative pathways
- Pentose catabolism
- Sugar acid dehydratase