TY - JOUR
T1 - Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways
T2 - Review
AU - Ren, Yaxin
AU - Eronen, Veikko
AU - Blomster Andberg, Martina
AU - Koivula, Anu
AU - Hakulinen, Nina
N1 - Funding Information:
This work was supported by the Academy of Finland (Decision 322619).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12/28
Y1 - 2022/12/28
N2 - Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as d-xylose and l-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.
AB - Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as d-xylose and l-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.
KW - Aldolase
KW - Aldopentose
KW - Aldose-1-dehydrogenase
KW - Ketoglutarate-semialdehyde dehydrogenase
KW - Lactonase
KW - Non-phosphorylative pathways
KW - Pentose catabolism
KW - Sugar acid dehydratase
UR - http://www.scopus.com/inward/record.url?scp=85145220854&partnerID=8YFLogxK
U2 - 10.1186/s13068-022-02252-5
DO - 10.1186/s13068-022-02252-5
M3 - Review Article
AN - SCOPUS:85145220854
SN - 2731-3654
VL - 15
JO - Biotechnology for Biofuels and Bioproducts
JF - Biotechnology for Biofuels and Bioproducts
IS - 1
M1 - 147
ER -