Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways: Review

Yaxin Ren, Veikko Eronen, Martina Blomster Andberg, Anu Koivula, Nina Hakulinen (Corresponding Author)

Research output: Contribution to journalReview Articlepeer-review

Abstract

Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as d-xylose and l-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.

Original languageEnglish
Article number147
Number of pages21
JournalBiotechnology for Biofuels and Bioproducts
Volume15
Issue number1
DOIs
Publication statusPublished - 28 Dec 2022
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Aldolase
  • Aldopentose
  • Aldose-1-dehydrogenase
  • Ketoglutarate-semialdehyde dehydrogenase
  • Lactonase
  • Non-phosphorylative pathways
  • Pentose catabolism
  • Sugar acid dehydratase

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