TY - JOUR
T1 - Suberin fatty acids from outer birch bark
T2 - Isolation and physical material characterization
AU - Heinämäki, Jyrki
AU - Pirttimaa, Minni M.
AU - Alakurtti, Sami
AU - Pitkänen, Pauliina H.
AU - Kanerva, Heimo
AU - Hulkko, Janne
AU - Paaver, Urve
AU - Aruväli, Jaan
AU - Yliruusi, Jouko
AU - Kogermann, Karin
PY - 2017/4/28
Y1 - 2017/4/28
N2 - The isolation and physical material properties of suberin
fatty acids (SFAs) were investigated with special
reference to their potential applications as novel
pharmaceutical excipients. SFAs were isolated from outer
birch bark (OBB) with a new extractive hydrolysis method.
The present simplified isolation process resulted in a
moderate batch yield and chemical purity of SFAs, but
further development is needed for establishing
batch-to-batch variation. Cryogenic milling was the
method of choice for the particle size reduction of SFAs
powder. The cryogenically milled SFAs powder exhibited a
semicrystalline structure with apparent microcrystalline
domains within an amorphous fatty acids matrix. The
thermogravimetric analysis (TGA) of SFAs samples showed a
good thermal stability up to 200 °C, followed by a
progressive weight loss, reaching a plateau at about 95%
volatilization at about 470 °C. The binary blends of SFAs
and microcrystalline cellulose (MCC; Avicel PH 101) in a
ratio of 25:75 (w/w) displayed good powder flow and
tablet compression properties. The corresponding
theophylline-containing tablets showed sustained or
prolonged-release characteristics. The physicochemical
and bulk powder properties of SFAs isolated from OBB are
auspicious in terms of potential pharmaceutical excipient
applications.
AB - The isolation and physical material properties of suberin
fatty acids (SFAs) were investigated with special
reference to their potential applications as novel
pharmaceutical excipients. SFAs were isolated from outer
birch bark (OBB) with a new extractive hydrolysis method.
The present simplified isolation process resulted in a
moderate batch yield and chemical purity of SFAs, but
further development is needed for establishing
batch-to-batch variation. Cryogenic milling was the
method of choice for the particle size reduction of SFAs
powder. The cryogenically milled SFAs powder exhibited a
semicrystalline structure with apparent microcrystalline
domains within an amorphous fatty acids matrix. The
thermogravimetric analysis (TGA) of SFAs samples showed a
good thermal stability up to 200 °C, followed by a
progressive weight loss, reaching a plateau at about 95%
volatilization at about 470 °C. The binary blends of SFAs
and microcrystalline cellulose (MCC; Avicel PH 101) in a
ratio of 25:75 (w/w) displayed good powder flow and
tablet compression properties. The corresponding
theophylline-containing tablets showed sustained or
prolonged-release characteristics. The physicochemical
and bulk powder properties of SFAs isolated from OBB are
auspicious in terms of potential pharmaceutical excipient
applications.
UR - http://www.scopus.com/inward/record.url?scp=85018384815&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.6b00771
DO - 10.1021/acs.jnatprod.6b00771
M3 - Article
VL - 80
SP - 916
EP - 924
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 4
ER -