Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 916-924 |
| Number of pages | 9 |
| Journal | Journal of Natural Products |
| Volume | 80 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 28 Apr 2017 |
| MoE publication type | A1 Journal article-refereed |
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Suberin fatty acids from outer birch bark: Isolation and physical material characterization. / Heinämäki, Jyrki; Pirttimaa, Minni M.; Alakurtti, Sami; Pitkänen, Pauliina H.; Kanerva, Heimo; Hulkko, Janne; Paaver, Urve; Aruväli, Jaan; Yliruusi, Jouko; Kogermann, Karin.
In: Journal of Natural Products, Vol. 80, No. 4, 28.04.2017, p. 916-924.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Suberin fatty acids from outer birch bark: Isolation and physical material characterization
AU - Heinämäki, Jyrki
AU - Pirttimaa, Minni M.
AU - Alakurtti, Sami
AU - Pitkänen, Pauliina H.
AU - Kanerva, Heimo
AU - Hulkko, Janne
AU - Paaver, Urve
AU - Aruväli, Jaan
AU - Yliruusi, Jouko
AU - Kogermann, Karin
PY - 2017/4/28
Y1 - 2017/4/28
N2 - The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.
AB - The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.
UR - http://www.scopus.com/inward/record.url?scp=85018384815&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.6b00771
DO - 10.1021/acs.jnatprod.6b00771
M3 - Article
VL - 80
SP - 916
EP - 924
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 4
ER -