Suberin fatty acids from outer birch bark: Isolation and physical material characterization

Jyrki Heinämäki, Minni M. Pirttimaa, Sami Alakurtti, Pauliina H. Pitkänen, Heimo Kanerva, Janne Hulkko, Urve Paaver, Jaan Aruväli, Jouko Yliruusi, Karin Kogermann

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.
Original languageEnglish
Pages (from-to)916-924
Number of pages9
JournalJournal of Natural Products
Volume80
Issue number4
DOIs
Publication statusPublished - 28 Apr 2017
MoE publication typeA1 Journal article-refereed

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Betula
Fatty Acids
Powders
Excipients
Tablets
suberin
Volatilization
Theophylline
Vaporization
Particle Size
Pharmaceutical Preparations
Cryogenics
Thermogravimetric analysis
Weight Loss
Hydrolysis
Materials properties
Thermodynamic stability
Hot Temperature
Particle size

Cite this

Heinämäki, Jyrki ; Pirttimaa, Minni M. ; Alakurtti, Sami ; Pitkänen, Pauliina H. ; Kanerva, Heimo ; Hulkko, Janne ; Paaver, Urve ; Aruväli, Jaan ; Yliruusi, Jouko ; Kogermann, Karin. / Suberin fatty acids from outer birch bark: Isolation and physical material characterization. In: Journal of Natural Products. 2017 ; Vol. 80, No. 4. pp. 916-924.
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abstract = "The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95{\%} volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.",
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Heinämäki, J, Pirttimaa, MM, Alakurtti, S, Pitkänen, PH, Kanerva, H, Hulkko, J, Paaver, U, Aruväli, J, Yliruusi, J & Kogermann, K 2017, 'Suberin fatty acids from outer birch bark: Isolation and physical material characterization', Journal of Natural Products, vol. 80, no. 4, pp. 916-924. https://doi.org/10.1021/acs.jnatprod.6b00771

Suberin fatty acids from outer birch bark: Isolation and physical material characterization. / Heinämäki, Jyrki; Pirttimaa, Minni M.; Alakurtti, Sami; Pitkänen, Pauliina H.; Kanerva, Heimo; Hulkko, Janne; Paaver, Urve; Aruväli, Jaan; Yliruusi, Jouko; Kogermann, Karin.

In: Journal of Natural Products, Vol. 80, No. 4, 28.04.2017, p. 916-924.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Heinämäki, Jyrki

AU - Pirttimaa, Minni M.

AU - Alakurtti, Sami

AU - Pitkänen, Pauliina H.

AU - Kanerva, Heimo

AU - Hulkko, Janne

AU - Paaver, Urve

AU - Aruväli, Jaan

AU - Yliruusi, Jouko

AU - Kogermann, Karin

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N2 - The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.

AB - The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications.

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U2 - 10.1021/acs.jnatprod.6b00771

DO - 10.1021/acs.jnatprod.6b00771

M3 - Article

VL - 80

SP - 916

EP - 924

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

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