Suberin fatty acids isolated from outer birch bark improve moisture barrier properties of cellulose ether films intended for tablet coatings

Jyrki Heinämäki, Anna Halenius, Maaja Paavo, Sami Alakurtti, Pauliina Pitkänen, Minni Pirttimaa, Urve Paaver, Kalle Kirsimäe, Karin Kogermann, Jouko Yliruusi

    Research output: Contribution to journalArticleScientificpeer-review

    10 Citations (Scopus)

    Abstract

    Abstract We showed that the addition of suberin fatty acids (SFAs) even at small concentrations significantly improves the water vapor barrier properties of hydroxypropyl methylcellulose (HPMC) films. SFAs were isolated from the outer birch bark using extractive hydrolysis. The effects of SFAs on the film formation of aqueous HPMC were investigated with free films plasticized with polyethylene glycol (PEG 400). Special attention was paid on the physical solid-state, moisture barrier and mechanical stress-strain properties of films intended for tablet film coatings. Topography and surface morphology, glass transition temperature (Tg), tensile strength, Young's modulus, and water vapor permeation (WVP) of films were studied. The addition of SFAs lowered the Tg of films suggesting partial enhancement in film plasticization. The WVP of films decreased with increasing SFAs concentration up to 15% (calculated as a % w/w from a polymer weight). The WVP value for a non-suberized reference film and suberized film plasticized with PEG 400 was 2.13 * 10-6 and 0.69[ * 10-6 g/(mm2 * h) * mm/Pa], respectively. The addition of SFAs impaired the mechanical stress-strain properties of HPMC films by reducing the deformation capacity of film. In conclusion, the film properties and performance of aqueous HPMC can be modified by including SFAs in the films.
    Original languageEnglish
    Pages (from-to)91-99
    JournalInternational Journal of Pharmaceutics
    Volume489
    Issue number1-2
    DOIs
    Publication statusPublished - 2015
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Betula
    Cellulose
    Ether
    Tablets
    Fatty Acids
    Steam
    Mechanical Stress
    Transition Temperature
    Tensile Strength
    Elastic Modulus
    suberin
    Glass
    Polymers
    Hydrolysis
    Weights and Measures
    Hypromellose Derivatives

    Keywords

    • birch bark
    • free films
    • hydroxypropyl methylcellulose
    • mechanical properties
    • suberin fatty acids
    • water vapor permeation

    Cite this

    Heinämäki, Jyrki ; Halenius, Anna ; Paavo, Maaja ; Alakurtti, Sami ; Pitkänen, Pauliina ; Pirttimaa, Minni ; Paaver, Urve ; Kirsimäe, Kalle ; Kogermann, Karin ; Yliruusi, Jouko. / Suberin fatty acids isolated from outer birch bark improve moisture barrier properties of cellulose ether films intended for tablet coatings. In: International Journal of Pharmaceutics. 2015 ; Vol. 489, No. 1-2. pp. 91-99.
    @article{570cdc7e94444cc9ac04881027df6327,
    title = "Suberin fatty acids isolated from outer birch bark improve moisture barrier properties of cellulose ether films intended for tablet coatings",
    abstract = "Abstract We showed that the addition of suberin fatty acids (SFAs) even at small concentrations significantly improves the water vapor barrier properties of hydroxypropyl methylcellulose (HPMC) films. SFAs were isolated from the outer birch bark using extractive hydrolysis. The effects of SFAs on the film formation of aqueous HPMC were investigated with free films plasticized with polyethylene glycol (PEG 400). Special attention was paid on the physical solid-state, moisture barrier and mechanical stress-strain properties of films intended for tablet film coatings. Topography and surface morphology, glass transition temperature (Tg), tensile strength, Young's modulus, and water vapor permeation (WVP) of films were studied. The addition of SFAs lowered the Tg of films suggesting partial enhancement in film plasticization. The WVP of films decreased with increasing SFAs concentration up to 15{\%} (calculated as a {\%} w/w from a polymer weight). The WVP value for a non-suberized reference film and suberized film plasticized with PEG 400 was 2.13 * 10-6 and 0.69[ * 10-6 g/(mm2 * h) * mm/Pa], respectively. The addition of SFAs impaired the mechanical stress-strain properties of HPMC films by reducing the deformation capacity of film. In conclusion, the film properties and performance of aqueous HPMC can be modified by including SFAs in the films.",
    keywords = "birch bark, free films, hydroxypropyl methylcellulose, mechanical properties, suberin fatty acids, water vapor permeation",
    author = "Jyrki Hein{\"a}m{\"a}ki and Anna Halenius and Maaja Paavo and Sami Alakurtti and Pauliina Pitk{\"a}nen and Minni Pirttimaa and Urve Paaver and Kalle Kirsim{\"a}e and Karin Kogermann and Jouko Yliruusi",
    year = "2015",
    doi = "10.1016/j.ijpharm.2015.04.066",
    language = "English",
    volume = "489",
    pages = "91--99",
    journal = "International Journal of Pharmaceutics",
    issn = "0378-5173",
    publisher = "Elsevier",
    number = "1-2",

    }

    Heinämäki, J, Halenius, A, Paavo, M, Alakurtti, S, Pitkänen, P, Pirttimaa, M, Paaver, U, Kirsimäe, K, Kogermann, K & Yliruusi, J 2015, 'Suberin fatty acids isolated from outer birch bark improve moisture barrier properties of cellulose ether films intended for tablet coatings', International Journal of Pharmaceutics, vol. 489, no. 1-2, pp. 91-99. https://doi.org/10.1016/j.ijpharm.2015.04.066

    Suberin fatty acids isolated from outer birch bark improve moisture barrier properties of cellulose ether films intended for tablet coatings. / Heinämäki, Jyrki; Halenius, Anna; Paavo, Maaja; Alakurtti, Sami; Pitkänen, Pauliina; Pirttimaa, Minni; Paaver, Urve; Kirsimäe, Kalle; Kogermann, Karin; Yliruusi, Jouko.

    In: International Journal of Pharmaceutics, Vol. 489, No. 1-2, 2015, p. 91-99.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Suberin fatty acids isolated from outer birch bark improve moisture barrier properties of cellulose ether films intended for tablet coatings

    AU - Heinämäki, Jyrki

    AU - Halenius, Anna

    AU - Paavo, Maaja

    AU - Alakurtti, Sami

    AU - Pitkänen, Pauliina

    AU - Pirttimaa, Minni

    AU - Paaver, Urve

    AU - Kirsimäe, Kalle

    AU - Kogermann, Karin

    AU - Yliruusi, Jouko

    PY - 2015

    Y1 - 2015

    N2 - Abstract We showed that the addition of suberin fatty acids (SFAs) even at small concentrations significantly improves the water vapor barrier properties of hydroxypropyl methylcellulose (HPMC) films. SFAs were isolated from the outer birch bark using extractive hydrolysis. The effects of SFAs on the film formation of aqueous HPMC were investigated with free films plasticized with polyethylene glycol (PEG 400). Special attention was paid on the physical solid-state, moisture barrier and mechanical stress-strain properties of films intended for tablet film coatings. Topography and surface morphology, glass transition temperature (Tg), tensile strength, Young's modulus, and water vapor permeation (WVP) of films were studied. The addition of SFAs lowered the Tg of films suggesting partial enhancement in film plasticization. The WVP of films decreased with increasing SFAs concentration up to 15% (calculated as a % w/w from a polymer weight). The WVP value for a non-suberized reference film and suberized film plasticized with PEG 400 was 2.13 * 10-6 and 0.69[ * 10-6 g/(mm2 * h) * mm/Pa], respectively. The addition of SFAs impaired the mechanical stress-strain properties of HPMC films by reducing the deformation capacity of film. In conclusion, the film properties and performance of aqueous HPMC can be modified by including SFAs in the films.

    AB - Abstract We showed that the addition of suberin fatty acids (SFAs) even at small concentrations significantly improves the water vapor barrier properties of hydroxypropyl methylcellulose (HPMC) films. SFAs were isolated from the outer birch bark using extractive hydrolysis. The effects of SFAs on the film formation of aqueous HPMC were investigated with free films plasticized with polyethylene glycol (PEG 400). Special attention was paid on the physical solid-state, moisture barrier and mechanical stress-strain properties of films intended for tablet film coatings. Topography and surface morphology, glass transition temperature (Tg), tensile strength, Young's modulus, and water vapor permeation (WVP) of films were studied. The addition of SFAs lowered the Tg of films suggesting partial enhancement in film plasticization. The WVP of films decreased with increasing SFAs concentration up to 15% (calculated as a % w/w from a polymer weight). The WVP value for a non-suberized reference film and suberized film plasticized with PEG 400 was 2.13 * 10-6 and 0.69[ * 10-6 g/(mm2 * h) * mm/Pa], respectively. The addition of SFAs impaired the mechanical stress-strain properties of HPMC films by reducing the deformation capacity of film. In conclusion, the film properties and performance of aqueous HPMC can be modified by including SFAs in the films.

    KW - birch bark

    KW - free films

    KW - hydroxypropyl methylcellulose

    KW - mechanical properties

    KW - suberin fatty acids

    KW - water vapor permeation

    U2 - 10.1016/j.ijpharm.2015.04.066

    DO - 10.1016/j.ijpharm.2015.04.066

    M3 - Article

    VL - 489

    SP - 91

    EP - 99

    JO - International Journal of Pharmaceutics

    JF - International Journal of Pharmaceutics

    SN - 0378-5173

    IS - 1-2

    ER -