[11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment

A. Brück (Corresponding Author), J.R. Virta, J. Koivunen, Juha Koikkalainen, N.M. Scheinin, H. Helenius, K. Någren, S. Helin, R. Parkkola, M. Viitanen, J.O. Rinne

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Abstract

Purpose: Cortical glucose metabolism, brain amyloid β accumulation and hippocampal atrophy imaging have all been suggested as potential biomarkers in predicting which patients with mild cognitive impairment (MCI) will convert to Alzheimer’s disease (AD). The aim of this study was to compare the prognostic ability of [11C]PIB PET, [18F]FDG PET and quantitative hippocampal volumes measured with MR imaging in predicting conversion to AD in patients with MCI. Methods: The study group comprised 29 patients with MCI who underwent [11C]PIB PET and MR imaging. Of these, 22 also underwent [18F]FDG PET. All subjects were invited back for clinical evaluation after 2 years. Results: During the follow-up time 17 patients had converted to AD while 12 continued to meet the criteria for MCI. The two groups did not differ in age, gender or education level, but the converter group tended to have lower MMSE and Word List learning than the nonconverter group. High [11C]PIB retention in the frontotemporal regions and anterior and posterior cingulate (p < 0.05) predicted conversion to AD. Also reduced [18F]FDG uptake in the left lateral temporal cortex (LTC) predicted conversion (p < 0.05), but quantitative hippocampal volumes did not (p > 0.1). In receiver operating characteristic (ROC) analysis the measurements that best predicted the conversion were [11C]PIB retention in the lateral frontal cortex and [18F]FDG uptake in the left LTC. Both PET methods resulted in good sensitivity and specificity and neither was significantly superior to the other. Conclusion: The findings indicate that [11C]PIB and [18F]FDG are superior to hippocampal volumes in predicting conversion to AD in patients with MCI.
Original languageEnglish
Pages (from-to)1567-1572
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume40
Issue number10
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Fluorodeoxyglucose F18
Alzheimer Disease
Aptitude
Gyrus Cinguli
Frontal Lobe
Amyloid
ROC Curve
Atrophy
Biomarkers
N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole
Cognitive Dysfunction
Learning
Education
Glucose
Sensitivity and Specificity
Brain

Keywords

  • [11C]PIB PET
  • [18F]FDG PET
  • Alzheimer's disease
  • conversion to Alzheimer's disease
  • mild cognitive impariment

Cite this

Brück, A., Virta, J. R., Koivunen, J., Koikkalainen, J., Scheinin, N. M., Helenius, H., ... Rinne, J. O. (2013). [11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment. European Journal of Nuclear Medicine and Molecular Imaging, 40(10), 1567-1572. https://doi.org/10.1007/s00259-013-2478-8
Brück, A. ; Virta, J.R. ; Koivunen, J. ; Koikkalainen, Juha ; Scheinin, N.M. ; Helenius, H. ; Någren, K. ; Helin, S. ; Parkkola, R. ; Viitanen, M. ; Rinne, J.O. / [11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment. In: European Journal of Nuclear Medicine and Molecular Imaging. 2013 ; Vol. 40, No. 10. pp. 1567-1572.
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abstract = "Purpose: Cortical glucose metabolism, brain amyloid β accumulation and hippocampal atrophy imaging have all been suggested as potential biomarkers in predicting which patients with mild cognitive impairment (MCI) will convert to Alzheimer’s disease (AD). The aim of this study was to compare the prognostic ability of [11C]PIB PET, [18F]FDG PET and quantitative hippocampal volumes measured with MR imaging in predicting conversion to AD in patients with MCI. Methods: The study group comprised 29 patients with MCI who underwent [11C]PIB PET and MR imaging. Of these, 22 also underwent [18F]FDG PET. All subjects were invited back for clinical evaluation after 2 years. Results: During the follow-up time 17 patients had converted to AD while 12 continued to meet the criteria for MCI. The two groups did not differ in age, gender or education level, but the converter group tended to have lower MMSE and Word List learning than the nonconverter group. High [11C]PIB retention in the frontotemporal regions and anterior and posterior cingulate (p < 0.05) predicted conversion to AD. Also reduced [18F]FDG uptake in the left lateral temporal cortex (LTC) predicted conversion (p < 0.05), but quantitative hippocampal volumes did not (p > 0.1). In receiver operating characteristic (ROC) analysis the measurements that best predicted the conversion were [11C]PIB retention in the lateral frontal cortex and [18F]FDG uptake in the left LTC. Both PET methods resulted in good sensitivity and specificity and neither was significantly superior to the other. Conclusion: The findings indicate that [11C]PIB and [18F]FDG are superior to hippocampal volumes in predicting conversion to AD in patients with MCI.",
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Brück, A, Virta, JR, Koivunen, J, Koikkalainen, J, Scheinin, NM, Helenius, H, Någren, K, Helin, S, Parkkola, R, Viitanen, M & Rinne, JO 2013, '[11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment', European Journal of Nuclear Medicine and Molecular Imaging, vol. 40, no. 10, pp. 1567-1572. https://doi.org/10.1007/s00259-013-2478-8

[11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment. / Brück, A. (Corresponding Author); Virta, J.R.; Koivunen, J.; Koikkalainen, Juha; Scheinin, N.M.; Helenius, H.; Någren, K.; Helin, S.; Parkkola, R.; Viitanen, M.; Rinne, J.O.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 40, No. 10, 2013, p. 1567-1572.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - [11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment

AU - Brück, A.

AU - Virta, J.R.

AU - Koivunen, J.

AU - Koikkalainen, Juha

AU - Scheinin, N.M.

AU - Helenius, H.

AU - Någren, K.

AU - Helin, S.

AU - Parkkola, R.

AU - Viitanen, M.

AU - Rinne, J.O.

PY - 2013

Y1 - 2013

N2 - Purpose: Cortical glucose metabolism, brain amyloid β accumulation and hippocampal atrophy imaging have all been suggested as potential biomarkers in predicting which patients with mild cognitive impairment (MCI) will convert to Alzheimer’s disease (AD). The aim of this study was to compare the prognostic ability of [11C]PIB PET, [18F]FDG PET and quantitative hippocampal volumes measured with MR imaging in predicting conversion to AD in patients with MCI. Methods: The study group comprised 29 patients with MCI who underwent [11C]PIB PET and MR imaging. Of these, 22 also underwent [18F]FDG PET. All subjects were invited back for clinical evaluation after 2 years. Results: During the follow-up time 17 patients had converted to AD while 12 continued to meet the criteria for MCI. The two groups did not differ in age, gender or education level, but the converter group tended to have lower MMSE and Word List learning than the nonconverter group. High [11C]PIB retention in the frontotemporal regions and anterior and posterior cingulate (p < 0.05) predicted conversion to AD. Also reduced [18F]FDG uptake in the left lateral temporal cortex (LTC) predicted conversion (p < 0.05), but quantitative hippocampal volumes did not (p > 0.1). In receiver operating characteristic (ROC) analysis the measurements that best predicted the conversion were [11C]PIB retention in the lateral frontal cortex and [18F]FDG uptake in the left LTC. Both PET methods resulted in good sensitivity and specificity and neither was significantly superior to the other. Conclusion: The findings indicate that [11C]PIB and [18F]FDG are superior to hippocampal volumes in predicting conversion to AD in patients with MCI.

AB - Purpose: Cortical glucose metabolism, brain amyloid β accumulation and hippocampal atrophy imaging have all been suggested as potential biomarkers in predicting which patients with mild cognitive impairment (MCI) will convert to Alzheimer’s disease (AD). The aim of this study was to compare the prognostic ability of [11C]PIB PET, [18F]FDG PET and quantitative hippocampal volumes measured with MR imaging in predicting conversion to AD in patients with MCI. Methods: The study group comprised 29 patients with MCI who underwent [11C]PIB PET and MR imaging. Of these, 22 also underwent [18F]FDG PET. All subjects were invited back for clinical evaluation after 2 years. Results: During the follow-up time 17 patients had converted to AD while 12 continued to meet the criteria for MCI. The two groups did not differ in age, gender or education level, but the converter group tended to have lower MMSE and Word List learning than the nonconverter group. High [11C]PIB retention in the frontotemporal regions and anterior and posterior cingulate (p < 0.05) predicted conversion to AD. Also reduced [18F]FDG uptake in the left lateral temporal cortex (LTC) predicted conversion (p < 0.05), but quantitative hippocampal volumes did not (p > 0.1). In receiver operating characteristic (ROC) analysis the measurements that best predicted the conversion were [11C]PIB retention in the lateral frontal cortex and [18F]FDG uptake in the left LTC. Both PET methods resulted in good sensitivity and specificity and neither was significantly superior to the other. Conclusion: The findings indicate that [11C]PIB and [18F]FDG are superior to hippocampal volumes in predicting conversion to AD in patients with MCI.

KW - [11C]PIB PET

KW - [18F]FDG PET

KW - Alzheimer's disease

KW - conversion to Alzheimer's disease

KW - mild cognitive impariment

U2 - 10.1007/s00259-013-2478-8

DO - 10.1007/s00259-013-2478-8

M3 - Article

VL - 40

SP - 1567

EP - 1572

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 10

ER -