Surface plasmon resonance biosensors as a tool in antibody engineering

Kaija Alfthan

Research output: Contribution to journalArticleScientificpeer-review

35 Citations (Scopus)

Abstract

Modern gene technology combined with efficient microbial expression systems provides tools to produce antibodies with reduced functional size and improved binding properties as well as antibody fusions or novel antibodies.
Surface plasmon resonance based biosensors, which measure antigen–antibody interactions in real-time, can be used for a diverse characterization of the modified antibodies. To date, the majority of published work originates from real-time biospecific interaction analysis based on the BIAcore® instruments.
This article describes the range of applications in antibody engineering in which BIAcore has been applied.
Original languageEnglish
Pages (from-to)653-663
JournalBiosensors & Bioelectronics
Volume13
Issue number6
DOIs
Publication statusPublished - 1998
MoE publication typeA1 Journal article-refereed

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