Synthesis and Langmuir Film Formation of N-(ε- Maleimidoca-proyl)(dilinoleoylphosphatidyl)ethanolamine

Tapani Viitala (Corresponding Author), Martin Albers, Inger Vikholm, Jouko Peltonen

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

N-(ε-Maleimidocaproyl)(dilinoleoylphosphatidyl)ethanolamine (DLiPE-EMC) has been synthesized, representing a new polymerizable lipid with a linking group for covalent attachment of proteins for immunosensor applications.
The linker lipid could be prepared by performing both the synthesis and separation steps under argon and avoiding heating. The product was characterized by 600 MHz 1H NMR, mass, and UV−vis spectrometry.
Monomolecular films were successfully prepared on a Langmuir trough, and the characteristic surface pressure−area curves were measured on different subphases. A condensation of the monolayer could be achieved by introducing a micromolar concentration of uranyl ions in the subphase.
Surface pressure−area isotherms of pure and mixed DLiPE/DLiPE-EMC monolayers were also measured. UV irradiation experiments were performed to demonstrate the polymerizability of the mixed monolayers.
Original languageEnglish
Pages (from-to)1272-1277
JournalLangmuir
Volume14
Issue number5
DOIs
Publication statusPublished - 1998
MoE publication typeA1 Journal article-refereed

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