Synthesis and Properties of Water-Soluble Gold Colloids Covalently Derivatized with Neutral Polymer Monolayers

Claire Mangeney, Fabien Ferrage, Isabelle Aujard, Valerie Marchi-Artzner, Ludovic Jullien, Olivier Ouari, El Djouhar Rekai, Andre Laschewsky, Inger Vikholm, Janusz Sadowski

Research output: Contribution to journalArticleScientificpeer-review

126 Citations (Scopus)

Abstract

Citrate-capped gold nanoparticles as well as planar gold surfaces can be efficiently grafted with a covalently attached polymer monolayer a few nanometers thick, by simple contact of the metal surface with dilute aqueous solutions of hydrophilic polymers that are end-capped with disulfide moieties, as shown by UV/vis absorption, dynamic light scattering, and surface plasmon resonance studies.
The hydrophilic polymer-coated gold colloids can be freeze-dried and stored as powders that can be subsequently dissolved to yield stable aqueous dispersions, even at very large concentrations.
They allow for applying filtrations, gel permeation chromatography, or centrifugation. They do not suffer from undesirable nonspecific adsorption of proteins while allowing the diffusion of small species within the hydrogel surface coating.
In addition, specific properties of the original hydrophilic polymers are retained such as a lower critical solution temperature. The latter feature could be useful to enhance optical responses of functionalized gold surfaces toward interaction with various substrates.
Original languageEnglish
Pages (from-to)5811-5821
JournalJournal of the American Chemical Society
Volume124
Issue number20
DOIs
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed

Fingerprint

Gold Colloid
Colloids
Monolayers
Polymers
Gold
Water
Surface Plasmon Resonance
Centrifugation
Hydrogel
Gel permeation chromatography
Surface plasmon resonance
Dynamic light scattering
Dispersions
Hydrogels
Citric Acid
Disulfides
Powders
Nanoparticles
Contacts (fluid mechanics)
Adsorption

Keywords

  • gold
  • colloids
  • gold nanoparticles
  • nanoparticles
  • polymers
  • monolayers

Cite this

Mangeney, C., Ferrage, F., Aujard, I., Marchi-Artzner, V., Jullien, L., Ouari, O., ... Sadowski, J. (2002). Synthesis and Properties of Water-Soluble Gold Colloids Covalently Derivatized with Neutral Polymer Monolayers. Journal of the American Chemical Society, 124(20), 5811-5821. https://doi.org/10.1021/ja010796h
Mangeney, Claire ; Ferrage, Fabien ; Aujard, Isabelle ; Marchi-Artzner, Valerie ; Jullien, Ludovic ; Ouari, Olivier ; Rekai, El Djouhar ; Laschewsky, Andre ; Vikholm, Inger ; Sadowski, Janusz. / Synthesis and Properties of Water-Soluble Gold Colloids Covalently Derivatized with Neutral Polymer Monolayers. In: Journal of the American Chemical Society. 2002 ; Vol. 124, No. 20. pp. 5811-5821.
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abstract = "Citrate-capped gold nanoparticles as well as planar gold surfaces can be efficiently grafted with a covalently attached polymer monolayer a few nanometers thick, by simple contact of the metal surface with dilute aqueous solutions of hydrophilic polymers that are end-capped with disulfide moieties, as shown by UV/vis absorption, dynamic light scattering, and surface plasmon resonance studies. The hydrophilic polymer-coated gold colloids can be freeze-dried and stored as powders that can be subsequently dissolved to yield stable aqueous dispersions, even at very large concentrations. They allow for applying filtrations, gel permeation chromatography, or centrifugation. They do not suffer from undesirable nonspecific adsorption of proteins while allowing the diffusion of small species within the hydrogel surface coating. In addition, specific properties of the original hydrophilic polymers are retained such as a lower critical solution temperature. The latter feature could be useful to enhance optical responses of functionalized gold surfaces toward interaction with various substrates.",
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Mangeney, C, Ferrage, F, Aujard, I, Marchi-Artzner, V, Jullien, L, Ouari, O, Rekai, ED, Laschewsky, A, Vikholm, I & Sadowski, J 2002, 'Synthesis and Properties of Water-Soluble Gold Colloids Covalently Derivatized with Neutral Polymer Monolayers', Journal of the American Chemical Society, vol. 124, no. 20, pp. 5811-5821. https://doi.org/10.1021/ja010796h

Synthesis and Properties of Water-Soluble Gold Colloids Covalently Derivatized with Neutral Polymer Monolayers. / Mangeney, Claire; Ferrage, Fabien; Aujard, Isabelle; Marchi-Artzner, Valerie; Jullien, Ludovic; Ouari, Olivier; Rekai, El Djouhar; Laschewsky, Andre; Vikholm, Inger; Sadowski, Janusz.

In: Journal of the American Chemical Society, Vol. 124, No. 20, 2002, p. 5811-5821.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Synthesis and Properties of Water-Soluble Gold Colloids Covalently Derivatized with Neutral Polymer Monolayers

AU - Mangeney, Claire

AU - Ferrage, Fabien

AU - Aujard, Isabelle

AU - Marchi-Artzner, Valerie

AU - Jullien, Ludovic

AU - Ouari, Olivier

AU - Rekai, El Djouhar

AU - Laschewsky, Andre

AU - Vikholm, Inger

AU - Sadowski, Janusz

PY - 2002

Y1 - 2002

N2 - Citrate-capped gold nanoparticles as well as planar gold surfaces can be efficiently grafted with a covalently attached polymer monolayer a few nanometers thick, by simple contact of the metal surface with dilute aqueous solutions of hydrophilic polymers that are end-capped with disulfide moieties, as shown by UV/vis absorption, dynamic light scattering, and surface plasmon resonance studies. The hydrophilic polymer-coated gold colloids can be freeze-dried and stored as powders that can be subsequently dissolved to yield stable aqueous dispersions, even at very large concentrations. They allow for applying filtrations, gel permeation chromatography, or centrifugation. They do not suffer from undesirable nonspecific adsorption of proteins while allowing the diffusion of small species within the hydrogel surface coating. In addition, specific properties of the original hydrophilic polymers are retained such as a lower critical solution temperature. The latter feature could be useful to enhance optical responses of functionalized gold surfaces toward interaction with various substrates.

AB - Citrate-capped gold nanoparticles as well as planar gold surfaces can be efficiently grafted with a covalently attached polymer monolayer a few nanometers thick, by simple contact of the metal surface with dilute aqueous solutions of hydrophilic polymers that are end-capped with disulfide moieties, as shown by UV/vis absorption, dynamic light scattering, and surface plasmon resonance studies. The hydrophilic polymer-coated gold colloids can be freeze-dried and stored as powders that can be subsequently dissolved to yield stable aqueous dispersions, even at very large concentrations. They allow for applying filtrations, gel permeation chromatography, or centrifugation. They do not suffer from undesirable nonspecific adsorption of proteins while allowing the diffusion of small species within the hydrogel surface coating. In addition, specific properties of the original hydrophilic polymers are retained such as a lower critical solution temperature. The latter feature could be useful to enhance optical responses of functionalized gold surfaces toward interaction with various substrates.

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KW - gold nanoparticles

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