Synthesis, characterization, and thermal behavior of steroidal dendrons

Jarmo Ropponen, Jari Tamminen, Manu Lahtinen, Juha Linnanto, Kari Rissanen, Erkki Kolehmainen

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)


A series of novel dendritic steroidal polyesters of first and second generation has been synthesized in convergent fashion by the use of 2,2-bis(hydroxymethyl)propionic acid as a repeating unit. The first- and second-generation hydroxyfunctionalized dendrons with a variety of surface modifications were produced through the use of four bile acids: lithocholic acid (LCA), ursodeoxycholic acid (UDCA), deoxycholic acid (DCA), and cholic acid (CA). The thermal behavior of the steroidal dendrons was characterized by differential scanning calorimetry (DSC) and by thermogravimetric analysis (TGA). Finally, quantum chemical calculation methods were used to study the geometries of the dendrons and the occurrence of intramolecular hydrogen bonds in these dendritic molecules.
Original languageEnglish
Pages (from-to)73-84
JournalEuropean Journal of Organic Chemistry
Issue number1
Publication statusPublished - 27 Dec 2004
MoE publication typeA1 Journal article-refereed


  • Aliphatic esters
  • Bile acids
  • Dendrimers
  • Steroids
  • Thermal analysis


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