Synthesis of aliphatic α-hydroxy carboxylic acids via electrocarboxylation of aldehydes

Valtteri Oksanen; Kiia Malinen; Tom Wirtanen

doi:10.1039/d5ra07885g

Synthesis of aliphatic α-hydroxy carboxylic acids via electrocarboxylation of aldehydes

Valtteri Oksanen
, Kiia Malinen
, Tom Wirtanen^*

^*Corresponding author for this work

BA5205 Chemical and polymer synthesis

Aalto University

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Herein, we describe electrocarboxylation of aliphatic aldehydes in an undivided cell for the synthesis of aliphatic α-hydroxy acids (AHA). The electrosynthesis utilizes stable carbon-based electrodes providing safe and simple access to AHAs. Yields between 20 to 45% are acheived with seven substrates, some up to three times higher than with previous electrosynthesis protocols.

Original language	English
Pages (from-to)	45724-45728
Number of pages	5
Journal	RSC Advances
Volume	15
Issue number	53
DOIs	https://doi.org/10.1039/d5ra07885g
Publication status	Published - 21 Nov 2025
MoE publication type	A1 Journal article-refereed

Funding

T. W. is grateful for financial support from the Research Council of Finland (Grant no. 348889). V. O. acknowledges European Union NextGenerationEU for funding, which is part of the strategic research opening “Electric Storage” of VTT, launched with the support of the additional chapter of the RePowerEU investment and reform programme for sustainable growth in Finland.

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10.1039/d5ra07885gLicence: CC BY

d5ra07885gFinal published version, 491 KBLicence: CC BY

Cite this

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title = "Synthesis of aliphatic α-hydroxy carboxylic acids via electrocarboxylation of aldehydes",

abstract = "Herein, we describe electrocarboxylation of aliphatic aldehydes in an undivided cell for the synthesis of aliphatic α-hydroxy acids (AHA). The electrosynthesis utilizes stable carbon-based electrodes providing safe and simple access to AHAs. Yields between 20 to 45\% are acheived with seven substrates, some up to three times higher than with previous electrosynthesis protocols.",

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AU - Wirtanen, Tom

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N2 - Herein, we describe electrocarboxylation of aliphatic aldehydes in an undivided cell for the synthesis of aliphatic α-hydroxy acids (AHA). The electrosynthesis utilizes stable carbon-based electrodes providing safe and simple access to AHAs. Yields between 20 to 45% are acheived with seven substrates, some up to three times higher than with previous electrosynthesis protocols.

AB - Herein, we describe electrocarboxylation of aliphatic aldehydes in an undivided cell for the synthesis of aliphatic α-hydroxy acids (AHA). The electrosynthesis utilizes stable carbon-based electrodes providing safe and simple access to AHAs. Yields between 20 to 45% are acheived with seven substrates, some up to three times higher than with previous electrosynthesis protocols.

UR - https://www.scopus.com/pages/publications/105022485708

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DO - 10.1039/d5ra07885g

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ER -

Synthesis of aliphatic α-hydroxy carboxylic acids via electrocarboxylation of aldehydes

Abstract

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Paired Electrosynthetic Upgrading of Organic Molecules

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Synthesis of aliphatic α-hydroxy carboxylic acids via electrocarboxylation of aldehydes

Abstract

Funding

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Paired Electrosynthetic Upgrading of Organic Molecules

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