Abstract
A facile method for the preparation of conformationally rigid analogues
of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic
α-2 receptor agonist medetomidine has been developed. The efficient
benzyne [4+2] cycloaddition reaction was used to give the core
7-acetylbenzonorbornadiene structure, which was subsequently elaborated
to the corresponding imidazole-based syn and anti isomers by means of the classical Bredereck’s method.
Original language | English |
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Pages (from-to) | 2783-2790 |
Journal | Heterocycles |
Volume | 65 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2005 |
MoE publication type | A1 Journal article-refereed |