Abstract
A facile method for the preparation of conformationally rigid analogues
of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic
α-2 receptor agonist medetomidine has been developed. The efficient
benzyne [4+2] cycloaddition reaction was used to give the core
7-acetylbenzonorbornadiene structure, which was subsequently elaborated
to the corresponding imidazole-based syn and anti isomers by means of the classical Bredereck’s method.
| Original language | English |
|---|---|
| Pages (from-to) | 2783-2790 |
| Journal | Heterocycles |
| Volume | 65 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2005 |
| MoE publication type | A1 Journal article-refereed |
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Cite this
Yli-Kauhaluoma, J., Laine, A., Ratilainen, J., & Karjalainen, A. (2005). Synthesis of benzobicyclo[2.2.1]heptylimidazoles as conformationally constrained adrenergic receptor antagonists. Heterocycles, 65(11), 2783-2790. https://doi.org/10.3987/COM-05-10535