Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2783-2790 |
| Journal | Heterocycles |
| Volume | 65 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2005 |
| MoE publication type | A1 Journal article-refereed |
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Synthesis of benzobicyclo[2.2.1]heptylimidazoles as conformationally constrained adrenergic receptor antagonists. / Yli-Kauhaluoma, Jari; Laine, Aki; Ratilainen, Jari; Karjalainen, Arto.
In: Heterocycles, Vol. 65, No. 11, 2005, p. 2783-2790.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Synthesis of benzobicyclo[2.2.1]heptylimidazoles as conformationally constrained adrenergic receptor antagonists
AU - Yli-Kauhaluoma, Jari
AU - Laine, Aki
AU - Ratilainen, Jari
AU - Karjalainen, Arto
PY - 2005
Y1 - 2005
N2 - A facile method for the preparation of conformationally rigid analogues of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic α-2 receptor agonist medetomidine has been developed. The efficient benzyne [4+2] cycloaddition reaction was used to give the core 7-acetylbenzonorbornadiene structure, which was subsequently elaborated to the corresponding imidazole-based syn and anti isomers by means of the classical Bredereck’s method.
AB - A facile method for the preparation of conformationally rigid analogues of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic α-2 receptor agonist medetomidine has been developed. The efficient benzyne [4+2] cycloaddition reaction was used to give the core 7-acetylbenzonorbornadiene structure, which was subsequently elaborated to the corresponding imidazole-based syn and anti isomers by means of the classical Bredereck’s method.
U2 - 10.3987/COM-05-10535
DO - 10.3987/COM-05-10535
M3 - Article
VL - 65
SP - 2783
EP - 2790
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 11
ER -