Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions

Janne Raula, Annukka Kuivanen, Anna Lähde, Hua Jiang, Maxim Antopolsky, Jarno Kansikas, Esko I. Kauppinen

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

Preparation of -leucine nanoparticles by a process based on physical vapor deposition has been presented. In an aerosol flow reactor method, aqueous -leucine droplets were first dried followed by the sublimation of -leucine to produce vapor that upon vapor deposition resulted in -leucine nanoparticles with size ranging from 40 to 200 nm. Onset temperature for the sublimation of -leucine at concentrations from 0.02 to increased from 135 to , respectively.
The formation of nanoparticles was initiated in three different ways: (i) via droplet drying, (ii) via heterogeneous nucleation of -leucine vapor on solid -leucine particles, and (iii) via homogeneous nucleation of -leucine vapor to form new-born nanoparticles. Consequently, the saturation conditions of -leucine vapor in the reactor determined the resulting particle size, size distribution and number concentration, those depending very much on nucleation mode.
In general, the both nucleation modes produced narrow size distributions, that is, geometric standard deviation (GSD) was although the number concentration increased with the increased amount of -leucine vapor.
Upon desublimation and vapor deposition, -leucine formed leafy crystals whose size was the largest when produced from the heated section at the vicinity of the onset temperature and the smallest far above the onset temperature.
All the particles prepared in the conditions (i)–(iii) were crystalline. However, X-ray diffraction analysis showed preferential direction for crystal growth according to the way of particle formation.
Original languageEnglish
Pages (from-to)1172-1184
JournalJournal of Aerosol Science
Volume38
Issue number12
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Physical vapor deposition
Leucine
nucleation
Vapors
saturation
Nanoparticles
Nucleation
sublimation
Vapor deposition
droplet
Sublimation
crystal
temperature
Crystal growth
Temperature
X ray diffraction analysis
X-ray diffraction
particle size
Aerosols
aerosol

Keywords

  • L-leucine
  • nanoparticles
  • physical vapor deposition

Cite this

Raula, J., Kuivanen, A., Lähde, A., Jiang, H., Antopolsky, M., Kansikas, J., & Kauppinen, E. I. (2007). Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions. Journal of Aerosol Science, 38(12), 1172-1184. https://doi.org/10.1016/j.jaerosci.2007.08.009
Raula, Janne ; Kuivanen, Annukka ; Lähde, Anna ; Jiang, Hua ; Antopolsky, Maxim ; Kansikas, Jarno ; Kauppinen, Esko I. / Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions. In: Journal of Aerosol Science. 2007 ; Vol. 38, No. 12. pp. 1172-1184.
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abstract = "Preparation of -leucine nanoparticles by a process based on physical vapor deposition has been presented. In an aerosol flow reactor method, aqueous -leucine droplets were first dried followed by the sublimation of -leucine to produce vapor that upon vapor deposition resulted in -leucine nanoparticles with size ranging from 40 to 200 nm. Onset temperature for the sublimation of -leucine at concentrations from 0.02 to increased from 135 to , respectively. The formation of nanoparticles was initiated in three different ways: (i) via droplet drying, (ii) via heterogeneous nucleation of -leucine vapor on solid -leucine particles, and (iii) via homogeneous nucleation of -leucine vapor to form new-born nanoparticles. Consequently, the saturation conditions of -leucine vapor in the reactor determined the resulting particle size, size distribution and number concentration, those depending very much on nucleation mode. In general, the both nucleation modes produced narrow size distributions, that is, geometric standard deviation (GSD) was although the number concentration increased with the increased amount of -leucine vapor. Upon desublimation and vapor deposition, -leucine formed leafy crystals whose size was the largest when produced from the heated section at the vicinity of the onset temperature and the smallest far above the onset temperature. All the particles prepared in the conditions (i)–(iii) were crystalline. However, X-ray diffraction analysis showed preferential direction for crystal growth according to the way of particle formation.",
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author = "Janne Raula and Annukka Kuivanen and Anna L{\"a}hde and Hua Jiang and Maxim Antopolsky and Jarno Kansikas and Kauppinen, {Esko I.}",
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Raula, J, Kuivanen, A, Lähde, A, Jiang, H, Antopolsky, M, Kansikas, J & Kauppinen, EI 2007, 'Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions', Journal of Aerosol Science, vol. 38, no. 12, pp. 1172-1184. https://doi.org/10.1016/j.jaerosci.2007.08.009

Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions. / Raula, Janne; Kuivanen, Annukka; Lähde, Anna; Jiang, Hua; Antopolsky, Maxim; Kansikas, Jarno; Kauppinen, Esko I.

In: Journal of Aerosol Science, Vol. 38, No. 12, 2007, p. 1172-1184.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions

AU - Raula, Janne

AU - Kuivanen, Annukka

AU - Lähde, Anna

AU - Jiang, Hua

AU - Antopolsky, Maxim

AU - Kansikas, Jarno

AU - Kauppinen, Esko I.

PY - 2007

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N2 - Preparation of -leucine nanoparticles by a process based on physical vapor deposition has been presented. In an aerosol flow reactor method, aqueous -leucine droplets were first dried followed by the sublimation of -leucine to produce vapor that upon vapor deposition resulted in -leucine nanoparticles with size ranging from 40 to 200 nm. Onset temperature for the sublimation of -leucine at concentrations from 0.02 to increased from 135 to , respectively. The formation of nanoparticles was initiated in three different ways: (i) via droplet drying, (ii) via heterogeneous nucleation of -leucine vapor on solid -leucine particles, and (iii) via homogeneous nucleation of -leucine vapor to form new-born nanoparticles. Consequently, the saturation conditions of -leucine vapor in the reactor determined the resulting particle size, size distribution and number concentration, those depending very much on nucleation mode. In general, the both nucleation modes produced narrow size distributions, that is, geometric standard deviation (GSD) was although the number concentration increased with the increased amount of -leucine vapor. Upon desublimation and vapor deposition, -leucine formed leafy crystals whose size was the largest when produced from the heated section at the vicinity of the onset temperature and the smallest far above the onset temperature. All the particles prepared in the conditions (i)–(iii) were crystalline. However, X-ray diffraction analysis showed preferential direction for crystal growth according to the way of particle formation.

AB - Preparation of -leucine nanoparticles by a process based on physical vapor deposition has been presented. In an aerosol flow reactor method, aqueous -leucine droplets were first dried followed by the sublimation of -leucine to produce vapor that upon vapor deposition resulted in -leucine nanoparticles with size ranging from 40 to 200 nm. Onset temperature for the sublimation of -leucine at concentrations from 0.02 to increased from 135 to , respectively. The formation of nanoparticles was initiated in three different ways: (i) via droplet drying, (ii) via heterogeneous nucleation of -leucine vapor on solid -leucine particles, and (iii) via homogeneous nucleation of -leucine vapor to form new-born nanoparticles. Consequently, the saturation conditions of -leucine vapor in the reactor determined the resulting particle size, size distribution and number concentration, those depending very much on nucleation mode. In general, the both nucleation modes produced narrow size distributions, that is, geometric standard deviation (GSD) was although the number concentration increased with the increased amount of -leucine vapor. Upon desublimation and vapor deposition, -leucine formed leafy crystals whose size was the largest when produced from the heated section at the vicinity of the onset temperature and the smallest far above the onset temperature. All the particles prepared in the conditions (i)–(iii) were crystalline. However, X-ray diffraction analysis showed preferential direction for crystal growth according to the way of particle formation.

KW - L-leucine

KW - nanoparticles

KW - physical vapor deposition

U2 - 10.1016/j.jaerosci.2007.08.009

DO - 10.1016/j.jaerosci.2007.08.009

M3 - Article

VL - 38

SP - 1172

EP - 1184

JO - Journal of Aerosol Science

JF - Journal of Aerosol Science

SN - 0021-8502

IS - 12

ER -