Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

Sami Kilpinen, R. Autio, K. Ojala, Kristiina Iljin, Elmar Bucher, Henri Sara, T. Pisto, M. Saarela, Rolf Skotheim, Mari Björkman, John Mpindi, Saija Haapa-Paananen, Paula Vainio, Henrik Edgren, Maija Wolf, J. Astola, Matthias Nees, S. Hautaniemi, Olli Kallioniemi (Corresponding Author)

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Abstract

Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.
Original languageEnglish
JournalGenome Biology
Volume9
Issue numberR139
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

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bioinformatics
Computational Biology
gene expression
gene
Genes
genes
Gene Expression
sampling
cancer
Databases
Messenger RNA
neoplasms
analysis
tissue
tissues
experiment
Neoplasms
methodology

Cite this

Kilpinen, Sami ; Autio, R. ; Ojala, K. ; Iljin, Kristiina ; Bucher, Elmar ; Sara, Henri ; Pisto, T. ; Saarela, M. ; Skotheim, Rolf ; Björkman, Mari ; Mpindi, John ; Haapa-Paananen, Saija ; Vainio, Paula ; Edgren, Henrik ; Wolf, Maija ; Astola, J. ; Nees, Matthias ; Hautaniemi, S. ; Kallioniemi, Olli. / Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. In: Genome Biology. 2008 ; Vol. 9, No. R139.
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abstract = "Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.",
author = "Sami Kilpinen and R. Autio and K. Ojala and Kristiina Iljin and Elmar Bucher and Henri Sara and T. Pisto and M. Saarela and Rolf Skotheim and Mari Bj{\"o}rkman and John Mpindi and Saija Haapa-Paananen and Paula Vainio and Henrik Edgren and Maija Wolf and J. Astola and Matthias Nees and S. Hautaniemi and Olli Kallioniemi",
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Kilpinen, S, Autio, R, Ojala, K, Iljin, K, Bucher, E, Sara, H, Pisto, T, Saarela, M, Skotheim, R, Björkman, M, Mpindi, J, Haapa-Paananen, S, Vainio, P, Edgren, H, Wolf, M, Astola, J, Nees, M, Hautaniemi, S & Kallioniemi, O 2008, 'Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues', Genome Biology, vol. 9, no. R139. https://doi.org/10.1186/gb-2008-9-9-r139

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. / Kilpinen, Sami; Autio, R.; Ojala, K.; Iljin, Kristiina; Bucher, Elmar; Sara, Henri; Pisto, T.; Saarela, M.; Skotheim, Rolf; Björkman, Mari; Mpindi, John; Haapa-Paananen, Saija; Vainio, Paula; Edgren, Henrik; Wolf, Maija; Astola, J.; Nees, Matthias; Hautaniemi, S.; Kallioniemi, Olli (Corresponding Author).

In: Genome Biology, Vol. 9, No. R139, 2008.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

AU - Kilpinen, Sami

AU - Autio, R.

AU - Ojala, K.

AU - Iljin, Kristiina

AU - Bucher, Elmar

AU - Sara, Henri

AU - Pisto, T.

AU - Saarela, M.

AU - Skotheim, Rolf

AU - Björkman, Mari

AU - Mpindi, John

AU - Haapa-Paananen, Saija

AU - Vainio, Paula

AU - Edgren, Henrik

AU - Wolf, Maija

AU - Astola, J.

AU - Nees, Matthias

AU - Hautaniemi, S.

AU - Kallioniemi, Olli

PY - 2008

Y1 - 2008

N2 - Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.

AB - Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.

U2 - 10.1186/gb-2008-9-9-r139

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M3 - Article

VL - 9

JO - Genome Biology

JF - Genome Biology

SN - 1474-7596

IS - R139

ER -