TY - JOUR
T1 - Systematic Review and Meta-Analysis of Human Studies to Support a Quantitative Recommendation for Whole Grain Intake in Relation to Type 2 Diabetes
AU - Chanson-Rolle, Aurelie
AU - Meynier, Alexandra
AU - Aubin, François
AU - Lappi, Jenni
AU - Poutanen, Kaisa
AU - Vinoy, Sophie
AU - Braesco, Veronique
PY - 2015
Y1 - 2015
N2 - Background Due to the increasing evidence of their health
benefits, whole grains are recommended for consumption
worldwide. Such recommendations are, however, rarely
quantitative. Our aim was to perform a quantitative
evaluation of the relationship between whole grain
consumption and the occurrence of type 2 diabetes (T2D)
to support a recommendation on the daily consumption of
whole grains. Methods and Findings We conducted a
systematic review by searching three bibliographic
databases. We included human studies addressing the
relationship between whole grain consumption and T2D
occurrence, and providing quantitative information on
daily intake of whole grains. A dose-response
meta-regression analysis between whole grain intake and
T2D occurrence was performed, using a hierarchical mixed
least square linear regression model. Eight observational
studies were included (all but one prospective), with a
total of 15,573 cases of T2D among 316,051 participants.
Quantitative meta-regression demonstrated a significant
linear inverse relationship between whole grain intake
and T2D occurrence (P
AB - Background Due to the increasing evidence of their health
benefits, whole grains are recommended for consumption
worldwide. Such recommendations are, however, rarely
quantitative. Our aim was to perform a quantitative
evaluation of the relationship between whole grain
consumption and the occurrence of type 2 diabetes (T2D)
to support a recommendation on the daily consumption of
whole grains. Methods and Findings We conducted a
systematic review by searching three bibliographic
databases. We included human studies addressing the
relationship between whole grain consumption and T2D
occurrence, and providing quantitative information on
daily intake of whole grains. A dose-response
meta-regression analysis between whole grain intake and
T2D occurrence was performed, using a hierarchical mixed
least square linear regression model. Eight observational
studies were included (all but one prospective), with a
total of 15,573 cases of T2D among 316,051 participants.
Quantitative meta-regression demonstrated a significant
linear inverse relationship between whole grain intake
and T2D occurrence (P
U2 - 10.1371/journal.pone.0131377
DO - 10.1371/journal.pone.0131377
M3 - Article
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0131377
ER -