Systems biology strategies in studies of energy homeostasis in vivo

Matej Oresic, Antonio Vidal-Puig

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Abstract

In this chapter the authors report on their experience with the analysis and modeling of data obtained from studies of animal models related to obesity and metabolic syndrome. The complex interactions of genetic and environmental factors contributing to the failure of energy balance that lead to obesity, as well as tight systemic regulation to maintain energy homeostasis, require application of the systems biology strategy at the physiological level. In vivo systems offer the possibility of investigating not only the effects of specific genetic modifications or treatments in selected tissues and organs, but also to elucidate compensatory allostatic mechanisms induced to maintain the homeostasis of the whole system. A key challenge for systems biology is to characterize different systems’ responses in the context of activated pathways. One possible strategy is based on reconstruction of tissue specific pathways using lipidomics, or metabolomics in general, in combination with proteomic and transcriptomic profiles. This approach was applied to obese mouse model and revealed activation of multiple liver pathways that may lead to metabolic products, which may impair insulin sensitivity.
Original languageEnglish
Title of host publicationHandbook of Research on Systems Biology Applications in Medicine
EditorsAndriani Daskalaki
Place of PublicationHershey, PA, USA
PublisherIGI Global
Chapter21
Pages354-360
ISBN (Electronic)978-1-60566-077-6
ISBN (Print)978-1-60566-076-9
DOIs
Publication statusPublished - 2009
MoE publication typeA3 Part of a book or another research book

Fingerprint

homeostasis
obesity
animal models
Biological Sciences
metabolic syndrome
energy
metabolomics
transcriptomics
genetic engineering
insulin resistance
proteomics
energy balance
liver
environmental factors
tissues

Keywords

  • Adipose tissue
  • allostasis
  • ceramide
  • lipids
  • metabolomics
  • lipidomics
  • lipotoxicity
  • pathway instantiation

Cite this

Oresic, M., & Vidal-Puig, A. (2009). Systems biology strategies in studies of energy homeostasis in vivo. In A. Daskalaki (Ed.), Handbook of Research on Systems Biology Applications in Medicine (pp. 354-360). Hershey, PA, USA: IGI Global. https://doi.org/10.4018/978-1-60566-076-9.ch021
Oresic, Matej ; Vidal-Puig, Antonio. / Systems biology strategies in studies of energy homeostasis in vivo. Handbook of Research on Systems Biology Applications in Medicine. editor / Andriani Daskalaki. Hershey, PA, USA : IGI Global, 2009. pp. 354-360
@inbook{551b465a0d9a4d1b9e43f8662e10e9ff,
title = "Systems biology strategies in studies of energy homeostasis in vivo",
abstract = "In this chapter the authors report on their experience with the analysis and modeling of data obtained from studies of animal models related to obesity and metabolic syndrome. The complex interactions of genetic and environmental factors contributing to the failure of energy balance that lead to obesity, as well as tight systemic regulation to maintain energy homeostasis, require application of the systems biology strategy at the physiological level. In vivo systems offer the possibility of investigating not only the effects of specific genetic modifications or treatments in selected tissues and organs, but also to elucidate compensatory allostatic mechanisms induced to maintain the homeostasis of the whole system. A key challenge for systems biology is to characterize different systems’ responses in the context of activated pathways. One possible strategy is based on reconstruction of tissue specific pathways using lipidomics, or metabolomics in general, in combination with proteomic and transcriptomic profiles. This approach was applied to obese mouse model and revealed activation of multiple liver pathways that may lead to metabolic products, which may impair insulin sensitivity.",
keywords = "Adipose tissue, allostasis, ceramide, lipids, metabolomics, lipidomics, lipotoxicity, pathway instantiation",
author = "Matej Oresic and Antonio Vidal-Puig",
year = "2009",
doi = "10.4018/978-1-60566-076-9.ch021",
language = "English",
isbn = "978-1-60566-076-9",
pages = "354--360",
editor = "Andriani Daskalaki",
booktitle = "Handbook of Research on Systems Biology Applications in Medicine",
publisher = "IGI Global",
address = "United States",

}

Oresic, M & Vidal-Puig, A 2009, Systems biology strategies in studies of energy homeostasis in vivo. in A Daskalaki (ed.), Handbook of Research on Systems Biology Applications in Medicine. IGI Global, Hershey, PA, USA, pp. 354-360. https://doi.org/10.4018/978-1-60566-076-9.ch021

Systems biology strategies in studies of energy homeostasis in vivo. / Oresic, Matej; Vidal-Puig, Antonio.

Handbook of Research on Systems Biology Applications in Medicine. ed. / Andriani Daskalaki. Hershey, PA, USA : IGI Global, 2009. p. 354-360.

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

TY - CHAP

T1 - Systems biology strategies in studies of energy homeostasis in vivo

AU - Oresic, Matej

AU - Vidal-Puig, Antonio

PY - 2009

Y1 - 2009

N2 - In this chapter the authors report on their experience with the analysis and modeling of data obtained from studies of animal models related to obesity and metabolic syndrome. The complex interactions of genetic and environmental factors contributing to the failure of energy balance that lead to obesity, as well as tight systemic regulation to maintain energy homeostasis, require application of the systems biology strategy at the physiological level. In vivo systems offer the possibility of investigating not only the effects of specific genetic modifications or treatments in selected tissues and organs, but also to elucidate compensatory allostatic mechanisms induced to maintain the homeostasis of the whole system. A key challenge for systems biology is to characterize different systems’ responses in the context of activated pathways. One possible strategy is based on reconstruction of tissue specific pathways using lipidomics, or metabolomics in general, in combination with proteomic and transcriptomic profiles. This approach was applied to obese mouse model and revealed activation of multiple liver pathways that may lead to metabolic products, which may impair insulin sensitivity.

AB - In this chapter the authors report on their experience with the analysis and modeling of data obtained from studies of animal models related to obesity and metabolic syndrome. The complex interactions of genetic and environmental factors contributing to the failure of energy balance that lead to obesity, as well as tight systemic regulation to maintain energy homeostasis, require application of the systems biology strategy at the physiological level. In vivo systems offer the possibility of investigating not only the effects of specific genetic modifications or treatments in selected tissues and organs, but also to elucidate compensatory allostatic mechanisms induced to maintain the homeostasis of the whole system. A key challenge for systems biology is to characterize different systems’ responses in the context of activated pathways. One possible strategy is based on reconstruction of tissue specific pathways using lipidomics, or metabolomics in general, in combination with proteomic and transcriptomic profiles. This approach was applied to obese mouse model and revealed activation of multiple liver pathways that may lead to metabolic products, which may impair insulin sensitivity.

KW - Adipose tissue

KW - allostasis

KW - ceramide

KW - lipids

KW - metabolomics

KW - lipidomics

KW - lipotoxicity

KW - pathway instantiation

U2 - 10.4018/978-1-60566-076-9.ch021

DO - 10.4018/978-1-60566-076-9.ch021

M3 - Chapter or book article

SN - 978-1-60566-076-9

SP - 354

EP - 360

BT - Handbook of Research on Systems Biology Applications in Medicine

A2 - Daskalaki, Andriani

PB - IGI Global

CY - Hershey, PA, USA

ER -

Oresic M, Vidal-Puig A. Systems biology strategies in studies of energy homeostasis in vivo. In Daskalaki A, editor, Handbook of Research on Systems Biology Applications in Medicine. Hershey, PA, USA: IGI Global. 2009. p. 354-360 https://doi.org/10.4018/978-1-60566-076-9.ch021