TEM imaging of mass-selected polymer molecules

Albert Nasibulin, Esko Kauppinen, Bruce Thomson, J. Fernandez de la Mora

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)


Polyethylene glycol (PEG) molecules with masses below 1300 amu are electrosprayed (ES) from solution, mobility-selected at high resolution in a differential mobility analyzer (DMA), collected on a grid and imaged by transmission electron microscopy (ES–DMA–TEM). The DMA resolves individual n-mers, and selects only one out of the many present in the original sample. Ion identity is established from parallel mass spectra (ES-MS). The images reveal spherical particles 1.46 nm in diameter, in good agreement with the known ion mass and bulk density. The DMA-selection technique opens new paths for the study of very small particles.
Original languageEnglish
Pages (from-to)449-453
JournalJournal of Nanoparticle Research
Issue number5
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed


  • electrospray
  • DMA
  • differential mobility analyzer
  • MS
  • TEM
  • transmission electron microscopy
  • polymers
  • nanoparticles
  • polymeric nanoparticles
  • aerosols


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