Tetanic stimulus of ulnar nerve as a predictor of heart rate response to skin incision in propofol-remifentanil anaesthesia

M. Rantanen (Corresponding Author), H. Yppärilä-Wolters, Mark van Gils, A. Yli-Hankala, M. Huiku, M. Kymäläinen, Ilkka Korhonen

Research output: Contribution to journalArticleScientificpeer-review

24 Citations (Scopus)

Abstract

Background
To study adequate antinociception during general anaesthesia, tetanic stimulus of 5–10 s duration has been used previously as a standardized nociceptive stimulus.
However, such stimuli have been found to correlate poorly with intraoperative nociception.
We hypothesized that an electrical tetanic stimulus of the ulnar nerve, lasting 30 s, would provide a reliable experimental pain model.

Methods
Thirty-three patients, undergoing open abdominal surgery, were studied. Propofol and remifentanil were used for anaesthesia.
Patients were randomized to receive remifentanil at three target-controlled infusion levels (1, 3, or 5 ng ml−1) during short (5 s, Tet5) and a long-lasting (30 s, Tet30) tetanic (50 mA, 50 Hz) stimulus and skin incision.
RR intervals (RRI) were obtained from the ECG and the mean RRI before each stimulus (Tet5, Tet30, incision) was compared with that after the stimulus.

Results
At remifentanil level 1 ng ml−1, the RRI responses to tetanic stimuli and skin incision were prominent but with higher concentrations (3 and 5 mg ml−1), responses were very small. Tet30 (r2=0.780) was the best predictor of the RRI response to skin incision when compared with Tet5 (r2=0.611), remifentanil level (r2=0.340), or propofol level (r2=0.036).

Conclusions
Long-lasting tetanic stimulus of ulnar nerve may provide a better experimental pain model for surgical pain during general anaesthesia than shorter stimuli, which have been applied in earlier studies.
Original languageEnglish
Pages (from-to)509-513
JournalBritish Journal of Anaesthesia
Volume99
Issue number4
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Ulnar Nerve
Propofol
Anesthesia
Heart Rate
Skin
Pain
General Anesthesia
Theoretical Models
Nociception
Electrocardiography
remifentanil

Keywords

  • Anaesthetics i.v., propofol
  • Analgesia
  • Analgesics opioid, remifentanil
  • Pain, experimental

Cite this

Rantanen, M. ; Yppärilä-Wolters, H. ; van Gils, Mark ; Yli-Hankala, A. ; Huiku, M. ; Kymäläinen, M. ; Korhonen, Ilkka. / Tetanic stimulus of ulnar nerve as a predictor of heart rate response to skin incision in propofol-remifentanil anaesthesia. In: British Journal of Anaesthesia. 2007 ; Vol. 99, No. 4. pp. 509-513.
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title = "Tetanic stimulus of ulnar nerve as a predictor of heart rate response to skin incision in propofol-remifentanil anaesthesia",
abstract = "BackgroundTo study adequate antinociception during general anaesthesia, tetanic stimulus of 5–10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of the ulnar nerve, lasting 30 s, would provide a reliable experimental pain model.MethodsThirty-three patients, undergoing open abdominal surgery, were studied. Propofol and remifentanil were used for anaesthesia. Patients were randomized to receive remifentanil at three target-controlled infusion levels (1, 3, or 5 ng ml−1) during short (5 s, Tet5) and a long-lasting (30 s, Tet30) tetanic (50 mA, 50 Hz) stimulus and skin incision. RR intervals (RRI) were obtained from the ECG and the mean RRI before each stimulus (Tet5, Tet30, incision) was compared with that after the stimulus.ResultsAt remifentanil level 1 ng ml−1, the RRI responses to tetanic stimuli and skin incision were prominent but with higher concentrations (3 and 5 mg ml−1), responses were very small. Tet30 (r2=0.780) was the best predictor of the RRI response to skin incision when compared with Tet5 (r2=0.611), remifentanil level (r2=0.340), or propofol level (r2=0.036).ConclusionsLong-lasting tetanic stimulus of ulnar nerve may provide a better experimental pain model for surgical pain during general anaesthesia than shorter stimuli, which have been applied in earlier studies.",
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Tetanic stimulus of ulnar nerve as a predictor of heart rate response to skin incision in propofol-remifentanil anaesthesia. / Rantanen, M. (Corresponding Author); Yppärilä-Wolters, H.; van Gils, Mark; Yli-Hankala, A.; Huiku, M.; Kymäläinen, M.; Korhonen, Ilkka.

In: British Journal of Anaesthesia, Vol. 99, No. 4, 2007, p. 509-513.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Tetanic stimulus of ulnar nerve as a predictor of heart rate response to skin incision in propofol-remifentanil anaesthesia

AU - Rantanen, M.

AU - Yppärilä-Wolters, H.

AU - van Gils, Mark

AU - Yli-Hankala, A.

AU - Huiku, M.

AU - Kymäläinen, M.

AU - Korhonen, Ilkka

PY - 2007

Y1 - 2007

N2 - BackgroundTo study adequate antinociception during general anaesthesia, tetanic stimulus of 5–10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of the ulnar nerve, lasting 30 s, would provide a reliable experimental pain model.MethodsThirty-three patients, undergoing open abdominal surgery, were studied. Propofol and remifentanil were used for anaesthesia. Patients were randomized to receive remifentanil at three target-controlled infusion levels (1, 3, or 5 ng ml−1) during short (5 s, Tet5) and a long-lasting (30 s, Tet30) tetanic (50 mA, 50 Hz) stimulus and skin incision. RR intervals (RRI) were obtained from the ECG and the mean RRI before each stimulus (Tet5, Tet30, incision) was compared with that after the stimulus.ResultsAt remifentanil level 1 ng ml−1, the RRI responses to tetanic stimuli and skin incision were prominent but with higher concentrations (3 and 5 mg ml−1), responses were very small. Tet30 (r2=0.780) was the best predictor of the RRI response to skin incision when compared with Tet5 (r2=0.611), remifentanil level (r2=0.340), or propofol level (r2=0.036).ConclusionsLong-lasting tetanic stimulus of ulnar nerve may provide a better experimental pain model for surgical pain during general anaesthesia than shorter stimuli, which have been applied in earlier studies.

AB - BackgroundTo study adequate antinociception during general anaesthesia, tetanic stimulus of 5–10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of the ulnar nerve, lasting 30 s, would provide a reliable experimental pain model.MethodsThirty-three patients, undergoing open abdominal surgery, were studied. Propofol and remifentanil were used for anaesthesia. Patients were randomized to receive remifentanil at three target-controlled infusion levels (1, 3, or 5 ng ml−1) during short (5 s, Tet5) and a long-lasting (30 s, Tet30) tetanic (50 mA, 50 Hz) stimulus and skin incision. RR intervals (RRI) were obtained from the ECG and the mean RRI before each stimulus (Tet5, Tet30, incision) was compared with that after the stimulus.ResultsAt remifentanil level 1 ng ml−1, the RRI responses to tetanic stimuli and skin incision were prominent but with higher concentrations (3 and 5 mg ml−1), responses were very small. Tet30 (r2=0.780) was the best predictor of the RRI response to skin incision when compared with Tet5 (r2=0.611), remifentanil level (r2=0.340), or propofol level (r2=0.036).ConclusionsLong-lasting tetanic stimulus of ulnar nerve may provide a better experimental pain model for surgical pain during general anaesthesia than shorter stimuli, which have been applied in earlier studies.

KW - Anaesthetics i.v., propofol

KW - Analgesia

KW - Analgesics opioid, remifentanil

KW - Pain, experimental

U2 - 10.1093/bja/aem200

DO - 10.1093/bja/aem200

M3 - Article

VL - 99

SP - 509

EP - 513

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 4

ER -