The additional D-galacturonate reductase genes in Aspergillus niger and Hypocrea jecorina

Joosu Kuivanen (Corresponding author), Satu Hilditch, Dominik Mojzita, Merja Penttilä, Peter Richard

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Abstract

Pectin, a cheap and abundant raw material has a huge potential in white biotechnology. D-galacturonate, the main component of pectin, is catabolised
to pyruvate and glycerol through a reductive pathway in eukaryotic microorganisms like filamentous fungi. This pathway also enables the utilization of pectin for the production of more valuable compounds. An example from that is the production of meso-galactarate (mucic acid) in metabolically
engineered fungal strains. Enzymes functioning on the reductive D-galacturonate pathway are a D-galacturonate reductase, L-galactonate dehydratase, 2-keto-3-deoxy-galactonate aldolase and glyceraldehyde reductase. The genes coding for these enzymes in Aspergillus niger are gaaA, gaaB, gaaC and gaaD, respectively, while in Hypocrea jecorina (Trichoderma reesei) the corresponding genes are gar1, lgd1, lga1 and gld1. A. niger also has a homologue gene sequence for H. jecorina gar1 whereas H. jecorina has a homologue gene sequence for A. niger gaaA respectively. Functions of these
two additional D-galacturonate reductase genes have remained unclear. We have now studied the roles of these two genes.
Original languageEnglish
Title of host publication26th Fungal Genetics Conference at Asilomar March 15-20, 2011
PublisherGenetics Society of America
ChapterPoster Abstracts
Pages205
Publication statusPublished - 2011
MoE publication typeNot Eligible
Event26th Fungal Genetics Conference - Asilomar, United States
Duration: 15 Mar 201120 Mar 2011

Publication series

SeriesFungal Genetics Reports
NumberSupplement
Volume58

Conference

Conference26th Fungal Genetics Conference
CountryUnited States
CityAsilomar
Period15/03/1120/03/11

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    Kuivanen, J., Hilditch, S., Mojzita, D., Penttilä, M., & Richard, P. (2011). The additional D-galacturonate reductase genes in Aspergillus niger and Hypocrea jecorina. In 26th Fungal Genetics Conference at Asilomar March 15-20, 2011 (pp. 205). [362] Genetics Society of America. Fungal Genetics Reports, No. Supplement, Vol.. 58 http://www.fgsc.net/26thFGC/26FGCProgramAndAbstracts.pdf