The additional D-galacturonate reductase genes in Aspergillus niger and Hypocrea jecorina

Joosu Kuivanen (Corresponding author), Satu Hilditch, Dominik Mojzita, Merja Penttilä, Peter Richard

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific


    Pectin, a cheap and abundant raw material has a huge potential in white biotechnology. D-galacturonate, the main component of pectin, is catabolised
    to pyruvate and glycerol through a reductive pathway in eukaryotic microorganisms like filamentous fungi. This pathway also enables the utilization of pectin for the production of more valuable compounds. An example from that is the production of meso-galactarate (mucic acid) in metabolically
    engineered fungal strains. Enzymes functioning on the reductive D-galacturonate pathway are a D-galacturonate reductase, L-galactonate dehydratase, 2-keto-3-deoxy-galactonate aldolase and glyceraldehyde reductase. The genes coding for these enzymes in Aspergillus niger are gaaA, gaaB, gaaC and gaaD, respectively, while in Hypocrea jecorina (Trichoderma reesei) the corresponding genes are gar1, lgd1, lga1 and gld1. A. niger also has a homologue gene sequence for H. jecorina gar1 whereas H. jecorina has a homologue gene sequence for A. niger gaaA respectively. Functions of these
    two additional D-galacturonate reductase genes have remained unclear. We have now studied the roles of these two genes.
    Original languageEnglish
    Title of host publication26th Fungal Genetics Conference at Asilomar March 15-20, 2011
    PublisherGenetics Society of America
    ChapterPoster Abstracts
    Publication statusPublished - 2011
    MoE publication typeNot Eligible
    Event26th Fungal Genetics Conference - Asilomar, United States
    Duration: 15 Mar 201120 Mar 2011

    Publication series

    SeriesFungal Genetics Reports


    Conference26th Fungal Genetics Conference
    Country/TerritoryUnited States


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