The antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms

C. Plumed-Ferrer, K. Väkeväinen, H. Komulainen, M. Rautiainen, A. Smeds, J.- E. Raitanen, P. Eklund, S. Willför, Hanna-Leena Alakomi, Maria Saarela, A. von Wright (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

Abstract

The antimicrobial effects of the wood-associated polyphenolic compounds pinosylvin, pinosylvin monomethyl ether, astringin, piceatannol, isorhapontin, isorhapontigenin, cycloXMe, dHIMP, ArX, and ArXOH were assessed against both Gram-negative (Salmonella) and Gram-positive bacteria (Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus) and yeasts (Candida tropicalis, Saccharomyces cerevisiae). Particularly the stilbenes pinosylvin, its monomethyl ether and piceatannol demonstrated a clear antimicrobial activity, which in the case of pinosylvin was present also in food matrices like sauerkraut, gravlax and berry jam, but not in milk. The destabilization of the outer membrane of Gram-negative microorganisms, as well as interactions with the cell membrane, as indicated by the NPN uptake and LIVE/DEAD viability staining experiments, can be one of the specific mechanisms behind the antibacterial action. L. monocytogenes was particularly sensitive to pinosylvin, and this effect was also seen in L. monocytogenes internalized in intestinal Caco2 cells at non-cytotoxic pinosylvin concentrations. In general, the antimicrobial effects of pinosylvin were even more prominent than those of a related stilbene, resveratrol, well known for its various bioactivities. According to our results, pinosylvin could have potential as a natural disinfectant or biocide in some targeted applications.
Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalInternational Journal of Food Microbiology
Volume164
Issue number1
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

food spoilage
Polyphenols
anti-infective properties
food pathogens
Listeria monocytogenes
polyphenols
stilbenes
Food
ethers
organisms
sauerkraut
Candida tropicalis
jams
Staphylococcus epidermidis
biocides
food matrix
disinfectants
resveratrol
Gram-positive bacteria
Stilbenes

Keywords

  • wood associated phenolic compounds
  • stilbenes
  • pinosylvin
  • Salmonella
  • Listeria monocytogenes
  • Food spoilage

Cite this

Plumed-Ferrer, C., Väkeväinen, K., Komulainen, H., Rautiainen, M., Smeds, A., Raitanen, J. . E., ... von Wright, A. (2013). The antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms. International Journal of Food Microbiology, 164(1), 99-107. https://doi.org/10.1016/j.ijfoodmicro.2013.04.001
Plumed-Ferrer, C. ; Väkeväinen, K. ; Komulainen, H. ; Rautiainen, M. ; Smeds, A. ; Raitanen, J.- E. ; Eklund, P. ; Willför, S. ; Alakomi, Hanna-Leena ; Saarela, Maria ; von Wright, A. / The antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms. In: International Journal of Food Microbiology. 2013 ; Vol. 164, No. 1. pp. 99-107.
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abstract = "The antimicrobial effects of the wood-associated polyphenolic compounds pinosylvin, pinosylvin monomethyl ether, astringin, piceatannol, isorhapontin, isorhapontigenin, cycloXMe, dHIMP, ArX, and ArXOH were assessed against both Gram-negative (Salmonella) and Gram-positive bacteria (Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus) and yeasts (Candida tropicalis, Saccharomyces cerevisiae). Particularly the stilbenes pinosylvin, its monomethyl ether and piceatannol demonstrated a clear antimicrobial activity, which in the case of pinosylvin was present also in food matrices like sauerkraut, gravlax and berry jam, but not in milk. The destabilization of the outer membrane of Gram-negative microorganisms, as well as interactions with the cell membrane, as indicated by the NPN uptake and LIVE/DEAD viability staining experiments, can be one of the specific mechanisms behind the antibacterial action. L. monocytogenes was particularly sensitive to pinosylvin, and this effect was also seen in L. monocytogenes internalized in intestinal Caco2 cells at non-cytotoxic pinosylvin concentrations. In general, the antimicrobial effects of pinosylvin were even more prominent than those of a related stilbene, resveratrol, well known for its various bioactivities. According to our results, pinosylvin could have potential as a natural disinfectant or biocide in some targeted applications.",
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Plumed-Ferrer, C, Väkeväinen, K, Komulainen, H, Rautiainen, M, Smeds, A, Raitanen, JE, Eklund, P, Willför, S, Alakomi, H-L, Saarela, M & von Wright, A 2013, 'The antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms', International Journal of Food Microbiology, vol. 164, no. 1, pp. 99-107. https://doi.org/10.1016/j.ijfoodmicro.2013.04.001

The antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms. / Plumed-Ferrer, C.; Väkeväinen, K.; Komulainen, H.; Rautiainen, M.; Smeds, A.; Raitanen, J.- E.; Eklund, P.; Willför, S.; Alakomi, Hanna-Leena; Saarela, Maria; von Wright, A. (Corresponding Author).

In: International Journal of Food Microbiology, Vol. 164, No. 1, 2013, p. 99-107.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms

AU - Plumed-Ferrer, C.

AU - Väkeväinen, K.

AU - Komulainen, H.

AU - Rautiainen, M.

AU - Smeds, A.

AU - Raitanen, J.- E.

AU - Eklund, P.

AU - Willför, S.

AU - Alakomi, Hanna-Leena

AU - Saarela, Maria

AU - von Wright, A.

PY - 2013

Y1 - 2013

N2 - The antimicrobial effects of the wood-associated polyphenolic compounds pinosylvin, pinosylvin monomethyl ether, astringin, piceatannol, isorhapontin, isorhapontigenin, cycloXMe, dHIMP, ArX, and ArXOH were assessed against both Gram-negative (Salmonella) and Gram-positive bacteria (Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus) and yeasts (Candida tropicalis, Saccharomyces cerevisiae). Particularly the stilbenes pinosylvin, its monomethyl ether and piceatannol demonstrated a clear antimicrobial activity, which in the case of pinosylvin was present also in food matrices like sauerkraut, gravlax and berry jam, but not in milk. The destabilization of the outer membrane of Gram-negative microorganisms, as well as interactions with the cell membrane, as indicated by the NPN uptake and LIVE/DEAD viability staining experiments, can be one of the specific mechanisms behind the antibacterial action. L. monocytogenes was particularly sensitive to pinosylvin, and this effect was also seen in L. monocytogenes internalized in intestinal Caco2 cells at non-cytotoxic pinosylvin concentrations. In general, the antimicrobial effects of pinosylvin were even more prominent than those of a related stilbene, resveratrol, well known for its various bioactivities. According to our results, pinosylvin could have potential as a natural disinfectant or biocide in some targeted applications.

AB - The antimicrobial effects of the wood-associated polyphenolic compounds pinosylvin, pinosylvin monomethyl ether, astringin, piceatannol, isorhapontin, isorhapontigenin, cycloXMe, dHIMP, ArX, and ArXOH were assessed against both Gram-negative (Salmonella) and Gram-positive bacteria (Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus) and yeasts (Candida tropicalis, Saccharomyces cerevisiae). Particularly the stilbenes pinosylvin, its monomethyl ether and piceatannol demonstrated a clear antimicrobial activity, which in the case of pinosylvin was present also in food matrices like sauerkraut, gravlax and berry jam, but not in milk. The destabilization of the outer membrane of Gram-negative microorganisms, as well as interactions with the cell membrane, as indicated by the NPN uptake and LIVE/DEAD viability staining experiments, can be one of the specific mechanisms behind the antibacterial action. L. monocytogenes was particularly sensitive to pinosylvin, and this effect was also seen in L. monocytogenes internalized in intestinal Caco2 cells at non-cytotoxic pinosylvin concentrations. In general, the antimicrobial effects of pinosylvin were even more prominent than those of a related stilbene, resveratrol, well known for its various bioactivities. According to our results, pinosylvin could have potential as a natural disinfectant or biocide in some targeted applications.

KW - wood associated phenolic compounds

KW - stilbenes

KW - pinosylvin

KW - Salmonella

KW - Listeria monocytogenes

KW - Food spoilage

U2 - 10.1016/j.ijfoodmicro.2013.04.001

DO - 10.1016/j.ijfoodmicro.2013.04.001

M3 - Article

VL - 164

SP - 99

EP - 107

JO - International Journal of Food Microbiology

JF - International Journal of Food Microbiology

SN - 0168-1605

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