The case for plant-made veterinary immunotherapeutics

Edward Topp, Rebecca Irwin, Tim McAllister, Martin Lessard, Jussi J. Joensuu, Igor Kolotilin, Udo Conrad, Eva Stöger, Tsafrir Mor, Heribert Warzecha, Chris J. Hall, Michael D. McLean, Eric Cox, Bert Devriendt, Andrew Potter, Ann Depicker, Vikram Virdi, Larry Holbrook, Ketan Doshi, Marike DussaultRobert Friendship, Oksana Yarosh, Han Sang Yoo, Jacqueline MacDonald, Rima Menassa

    Research output: Contribution to journalReview Articlepeer-review

    28 Citations (Scopus)

    Abstract

    The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval.
    Original languageEnglish
    Pages (from-to)597-604
    JournalBiotechnology Advances
    Volume34
    Issue number5
    DOIs
    Publication statusPublished - 2016
    MoE publication typeA2 Review article in a scientific journal

    Keywords

    • antibiotic resistance
    • antibody
    • immunotherapeutic
    • livestock production
    • molecular farming
    • plant biotechnology
    • recombinant protein
    • veterinary vaccine

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