The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput (Corresponding Author), Jose M. Ordovas, Lynnette Ferguson, Kaisa Poutanen, et al.

Research output: Contribution to journalArticleScientificpeer-review

116 Citations (Scopus)

Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.
Original languageEnglish
Pages (from-to)623 - 632
Number of pages10
JournalBritish Journal of Nutrition
Volume94
Issue number5
DOIs
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fingerprint

Nutrigenomics
Public Health
Genes
Food
Medical Genetics
Developed Countries
Developing Countries
Epidemiologic Studies
Molecular Biology
Chronic Disease
Research Personnel
Diet
Phenotype
Health
Population

Keywords

  • strategic international alliances
  • nutrigenomics
  • gene–nutrient interactions
  • health diaparities

Cite this

Kaput, Jim ; Ordovas, Jose M. ; Ferguson, Lynnette ; Poutanen, Kaisa ; et al. / The case for strategic international alliances to harness nutritional genomics for public and personal health. In: British Journal of Nutrition. 2005 ; Vol. 94, No. 5. pp. 623 - 632.
@article{c39554d3b906447c80cf1ca32462103f,
title = "The case for strategic international alliances to harness nutritional genomics for public and personal health",
abstract = "Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.",
keywords = "strategic international alliances, nutrigenomics, gene–nutrient interactions, health diaparities",
author = "Jim Kaput and Ordovas, {Jose M.} and Lynnette Ferguson and Kaisa Poutanen and {et al.}",
year = "2005",
doi = "10.1079/BJN20051585",
language = "English",
volume = "94",
pages = "623 -- 632",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "5",

}

The case for strategic international alliances to harness nutritional genomics for public and personal health. / Kaput, Jim (Corresponding Author); Ordovas, Jose M.; Ferguson, Lynnette; Poutanen, Kaisa; et al.

In: British Journal of Nutrition, Vol. 94, No. 5, 2005, p. 623 - 632.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The case for strategic international alliances to harness nutritional genomics for public and personal health

AU - Kaput, Jim

AU - Ordovas, Jose M.

AU - Ferguson, Lynnette

AU - Poutanen, Kaisa

AU - et al., null

PY - 2005

Y1 - 2005

N2 - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

AB - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

KW - strategic international alliances

KW - nutrigenomics

KW - gene–nutrient interactions

KW - health diaparities

U2 - 10.1079/BJN20051585

DO - 10.1079/BJN20051585

M3 - Article

VL - 94

SP - 623

EP - 632

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 5

ER -