The effect of interruption to propofol sedation on auditory event-related potentials and electroencephalogram in intensive care patients

Heidi Yppärilä (Corresponding Author), Silvia Nunes, Ilkka Korhonen, Juhani Partanen, Esko Ruokonen

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Abstract

Introduction

In this observational pilot study we evaluated the electroencephalogram (EEG) and auditory event-related potentials (ERPs) before and after discontinuation of propofol sedation in neurologically intact intensive care patients.

Methods

Nineteen intensive care unit patients received a propofol infusion in accordance with a sedation protocol. The EEG signal and the ERPs were measured at the frontal region (Fz) and central region (Cz), both during propofol sedation and after cessation of infusion when the sedative effects had subsided. The EEG signal was subjected to power spectral estimation, and the total root mean squared power and spectral edge frequency 95% were computed. For ERPs, we used an oddball paradigm to obtain the N100 and the mismatch negativity components.

Results

Despite considerable individual variability, the root mean squared power at Cz and Fz (P = 0.004 and P = 0.005, respectively) and the amplitude of the N100 component in response to the standard stimulus at Fz (P = 0.022) increased significantly after interruption to sedation. The amplitude of the N100 component (at Cz and Fz) was the only parameter that differed between sedation levels during propofol sedation (deep versus moderate versus light sedation: P = 0.016 and P = 0.008 for Cz and Fz, respectively). None of the computed parameters correlated with duration of propofol infusion.

Conclusion

Our findings suggest that use of ERPs, especially the N100 potential, may help to differentiate between levels of sedation. Thus, they may represent a useful complement to clinical sedation scales in the monitoring of sedation status over time in a heterogeneous group of neurologically intact intensive care patients.

Original languageEnglish
Pages (from-to)R483-R490
JournalCritical Care
Volume8
Issue number6
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Keywords

  • electroencephalogram
  • event-related potentials
  • propofol
  • sedation
  • intensive care

Fingerprint Dive into the research topics of 'The effect of interruption to propofol sedation on auditory event-related potentials and electroencephalogram in intensive care patients'. Together they form a unique fingerprint.

Cite this