The effect of Staphylococcal cell wall ractor on endotoxin mastitis

Tiina Mattila, Denise O'Boyle, Alan Frost

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)


The effect of a cell wall extract of Staphylococcus aureus on the inflammatory response induced in the mammary gland by endotoxin was studied. Quarters of lactating cows were infused with 10 μg endotoxin with or without the cell wall extract. In the quarters receiving the cell wall extract, the clinical response was delayed and markedly diminished. Changes in levels of antitrypsin, which reflect changes in vascular permeability, followed a similar pattern. There were no differences in the somatic cell count and NAGase levels in the inoculated quarters. The growth stimulating effect for S. aureus in the whey was delayed in the quarters which received the cell wall extract. The specificity of the antiinflammatory effect of the cell wall extract therefore extends to endotoxin.
Original languageEnglish
Pages (from-to)743-748
JournalJournal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health
Issue number1-10
Publication statusPublished - 1987
MoE publication typeA1 Journal article-refereed


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