The Finnish boron neutron capture therapy (BNCT) project

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Boron neutron capture therapy (BNCT) is a new, binary radiotherapy, which is being developed especially for severe brain tumours, incurable by the present means (for an overview see articles in [1]). A suitable 10B containing carrier compound is injected into the blood circulation and taken up selectively by the cancer cells. When these cells are subjected to a thermal neutron field, the 10B atoms capture the neutrons and undergo fission reaction. The energy thereby released is killing the cancerous cell. The Finnish BNCT research and development project [2,3] is in the situation where all the basic conditions exist to start clinical trials. An epithermal neutron irradiation facility has been constructed at the Finnish research reactor (FiR 1) operated by VTT in Otaniemi. This article is an overview over the developments within the Finnish BNCT project. A research project to carry out clinical application of BNCT was established in Finland in the early 1990's. It was motivated both by the need to create new uses for FiR 1 and by the ideas to start research and production of new boron carriers for BNCT in Finland. Soon also other medical, medical physics and chemistry disciplines joined the project [2,4,5]. Now the project involves scientists from different departments of University of Helsinki (HU), Helsinki University Central Hospital (HUCH), Technical Research Centre of Finland (VTT), Finnish Radiation and Nuclear Safety Authority (STUK) and of the Helsinki University of Technology (HUT) and other Finnish universities. The aim of this project has been to start BNC-treatment of malignant brain tumours in Finland by the end of the century.
Original languageEnglish
Title of host publication15th European TRIGA Conference
Place of PublicationEspoo
PublisherVTT Technical Research Centre of Finland
Pages121-131
Publication statusPublished - 1999
MoE publication typeA4 Article in a conference publication
Event15th European TRIGA Conference - Espoo, Finland
Duration: 15 Jun 199817 Jun 1998

Publication series

NameVTT Symposium
PublisherVTT
Number197
ISSN (Print)0357-9387
ISSN (Electronic)1455-0873

Conference

Conference15th European TRIGA Conference
CountryFinland
CityEspoo
Period15/06/9817/06/98

Fingerprint

therapy
Finland
boron
neutrons
research projects
brain
tumors
blood circulation
neutron irradiation
thermal neutrons
cells
fission
radiation therapy
safety
cancer
reactors
chemistry
physics
radiation
atoms

Cite this

Auterinen, I. (1999). The Finnish boron neutron capture therapy (BNCT) project. In 15th European TRIGA Conference (pp. 121-131). Espoo: VTT Technical Research Centre of Finland. VTT Symposium, No. 197
Auterinen, Iiro. / The Finnish boron neutron capture therapy (BNCT) project. 15th European TRIGA Conference. Espoo : VTT Technical Research Centre of Finland, 1999. pp. 121-131 (VTT Symposium; No. 197).
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Auterinen, I 1999, The Finnish boron neutron capture therapy (BNCT) project. in 15th European TRIGA Conference. VTT Technical Research Centre of Finland, Espoo, VTT Symposium, no. 197, pp. 121-131, 15th European TRIGA Conference, Espoo, Finland, 15/06/98.

The Finnish boron neutron capture therapy (BNCT) project. / Auterinen, Iiro.

15th European TRIGA Conference. Espoo : VTT Technical Research Centre of Finland, 1999. p. 121-131 (VTT Symposium; No. 197).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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AB - Boron neutron capture therapy (BNCT) is a new, binary radiotherapy, which is being developed especially for severe brain tumours, incurable by the present means (for an overview see articles in [1]). A suitable 10B containing carrier compound is injected into the blood circulation and taken up selectively by the cancer cells. When these cells are subjected to a thermal neutron field, the 10B atoms capture the neutrons and undergo fission reaction. The energy thereby released is killing the cancerous cell. The Finnish BNCT research and development project [2,3] is in the situation where all the basic conditions exist to start clinical trials. An epithermal neutron irradiation facility has been constructed at the Finnish research reactor (FiR 1) operated by VTT in Otaniemi. This article is an overview over the developments within the Finnish BNCT project. A research project to carry out clinical application of BNCT was established in Finland in the early 1990's. It was motivated both by the need to create new uses for FiR 1 and by the ideas to start research and production of new boron carriers for BNCT in Finland. Soon also other medical, medical physics and chemistry disciplines joined the project [2,4,5]. Now the project involves scientists from different departments of University of Helsinki (HU), Helsinki University Central Hospital (HUCH), Technical Research Centre of Finland (VTT), Finnish Radiation and Nuclear Safety Authority (STUK) and of the Helsinki University of Technology (HUT) and other Finnish universities. The aim of this project has been to start BNC-treatment of malignant brain tumours in Finland by the end of the century.

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Auterinen I. The Finnish boron neutron capture therapy (BNCT) project. In 15th European TRIGA Conference. Espoo: VTT Technical Research Centre of Finland. 1999. p. 121-131. (VTT Symposium; No. 197).