The fluorous effect in biomolecular applications

M. Cametti, B. Crousse, P. Metrangolo (Corresponding Author), Roberto Milani, G. Resnati (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    223 Citations (Scopus)

    Abstract

    From being a niche area only a few decades ago, fluorous chemistry has gained momentum and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous applicative innovations that stretch among different fields: from catalysis to separation science, from supramolecular to materials and analytical chemistry. Recently, the unique features of perfluorinated compounds have reached the attention of the biochemists' audience. This tutorial review introduces the basic concepts of fluorous chemistry and illustrates its main biomolecular applications. Special attention has been given to fluorous microarrays and their combination with Mass-Spectroscopy (MS) techniques, to protein properties modification by the introduction of local fluorous domains, and to the most recent applications of 19F-Magnetic Resonance Imaging (19F-MRI).
    Original languageEnglish
    Pages (from-to)31-42
    Number of pages11
    JournalChemical Society Reviews
    Volume41
    Issue number1
    DOIs
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

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  • Cite this

    Cametti, M., Crousse, B., Metrangolo, P., Milani, R., & Resnati, G. (2012). The fluorous effect in biomolecular applications. Chemical Society Reviews, 41(1), 31-42. https://doi.org/10.1039/c1cs15084g