The fluorous effect in biomolecular applications

Massimo Cametti, Benoît Crousse, Pierangelo Metrangolo (Corresponding Author), Roberto Milani, Giuseppe Resnati (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    377 Citations (Scopus)


    From being a niche area only a few decades ago, fluorous chemistry has gained momentum and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous applicative innovations that stretch among different fields: from catalysis to separation science, from supramolecular to materials and analytical chemistry. Recently, the unique features of perfluorinated compounds have reached the attention of the biochemists' audience. This tutorial review introduces the basic concepts of fluorous chemistry and illustrates its main biomolecular applications. Special attention has been given to fluorous microarrays and their combination with Mass-Spectroscopy (MS) techniques, to protein properties modification by the introduction of local fluorous domains, and to the most recent applications of 19F-Magnetic Resonance Imaging (19F-MRI).
    Original languageEnglish
    Pages (from-to)31-42
    JournalChemical Society Reviews
    Issue number1
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed


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