The gut microbiota modulates host energy and lipid metabolism in mice

Vidya Velagapudi, Rahil Hezaveh, Christopher S. Reigstad, Peddinti Gopalacharyulu, Laxman Yetukuri, Sama Islam, Jenny Felin, Rosie Perkins, Jan Borén, Matej Orešič, Fredrik Backhed (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

294 Citations (Scopus)

Abstract

The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increased levels of energy metabolites, e.g., pyruvic acid, citric acid, fumaric acid, and malic acid, while levels of cholesterol and fatty acids were reduced. We also showed that the microbiota modified a number of lipid species in the serum, adipose tissue, and liver, with its greatest effect on triglyceride and phosphatidylcholine species. Triglyceride levels were lower in serum but higher in adipose tissue and liver of CONV-R mice, consistent with increased lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.
Original languageEnglish
Pages (from-to)1101-1112
JournalJournal of Lipid Research
Volume51
Issue number5
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fingerprint

Lipid Metabolism
Liver
Energy Metabolism
Tissue
Triglycerides
Adipose Tissue
Serum
Metabolome
Metabolic Diseases
Lipids
Metabolites
Phosphatidylcholines
Pyruvic Acid
Citric Acid
Fatty Acids
Cholesterol
Microbiota
Gastrointestinal Microbiome

Keywords

  • Lipase/Hepatic
  • Lipodystrophies
  • Phospholipids/Biosynthesis
  • Transcription
  • Gnotobiology
  • Lipidomics
  • Metabolomics
  • Microbiology

Cite this

Velagapudi, V., Hezaveh, R., Reigstad, C. S., Gopalacharyulu, P., Yetukuri, L., Islam, S., ... Backhed, F. (2010). The gut microbiota modulates host energy and lipid metabolism in mice. Journal of Lipid Research, 51(5), 1101-1112. https://doi.org/10.1194/jlr.M002774
Velagapudi, Vidya ; Hezaveh, Rahil ; Reigstad, Christopher S. ; Gopalacharyulu, Peddinti ; Yetukuri, Laxman ; Islam, Sama ; Felin, Jenny ; Perkins, Rosie ; Borén, Jan ; Orešič, Matej ; Backhed, Fredrik. / The gut microbiota modulates host energy and lipid metabolism in mice. In: Journal of Lipid Research. 2010 ; Vol. 51, No. 5. pp. 1101-1112.
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Velagapudi, V, Hezaveh, R, Reigstad, CS, Gopalacharyulu, P, Yetukuri, L, Islam, S, Felin, J, Perkins, R, Borén, J, Orešič, M & Backhed, F 2010, 'The gut microbiota modulates host energy and lipid metabolism in mice', Journal of Lipid Research, vol. 51, no. 5, pp. 1101-1112. https://doi.org/10.1194/jlr.M002774

The gut microbiota modulates host energy and lipid metabolism in mice. / Velagapudi, Vidya; Hezaveh, Rahil; Reigstad, Christopher S.; Gopalacharyulu, Peddinti; Yetukuri, Laxman; Islam, Sama; Felin, Jenny; Perkins, Rosie; Borén, Jan; Orešič, Matej; Backhed, Fredrik (Corresponding Author).

In: Journal of Lipid Research, Vol. 51, No. 5, 2010, p. 1101-1112.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Islam, Sama

AU - Felin, Jenny

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AU - Borén, Jan

AU - Orešič, Matej

AU - Backhed, Fredrik

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Velagapudi V, Hezaveh R, Reigstad CS, Gopalacharyulu P, Yetukuri L, Islam S et al. The gut microbiota modulates host energy and lipid metabolism in mice. Journal of Lipid Research. 2010;51(5):1101-1112. https://doi.org/10.1194/jlr.M002774