The Halogen Bond

Gabriella Cavallo, Pierangelo Metrangolo (Corresponding Author), Roberto Milani, Tullio Pilati, Arri Priimagi, Giuseppe Resnati (Corresponding Author), Giancarlo Terraneo

    Research output: Contribution to journalArticleScientificpeer-review

    2924 Citations (Scopus)


    The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.
    Original languageEnglish
    Pages (from-to)2478-2601
    JournalChemical Reviews
    Issue number4
    Publication statusPublished - 2016
    MoE publication typeA1 Journal article-refereed


    • halogen bond


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