The Halogen Bond

Gabriella Cavallo; Pierangelo Metrangolo; Roberto Milani; Tullio Pilati; Arri Priimagi; Giuseppe Resnati; Giancarlo Terraneo

doi:10.1021/acs.chemrev.5b00484

The Halogen Bond

Gabriella Cavallo, Pierangelo Metrangolo (Corresponding Author), Roberto Milani, Tullio Pilati, Arri Priimagi, Giuseppe Resnati (Corresponding Author), Giancarlo Terraneo

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.

Original language	English
Pages (from-to)	2478-2601
Journal	Chemical Reviews
Volume	116
Issue number	4
DOIs	https://doi.org/10.1021/acs.chemrev.5b00484
Publication status	Published - 2016
MoE publication type	A1 Journal article-refereed

Keywords

halogen bond

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10.1021/acs.chemrev.5b00484

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AU - Metrangolo, Pierangelo

AU - Milani, Roberto

AU - Pilati, Tullio

AU - Priimagi, Arri

AU - Resnati, Giuseppe

AU - Terraneo, Giancarlo

N1 - Project code: 100495 Project code: 101066

PY - 2016

Y1 - 2016

N2 - The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.

AB - The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.

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The Halogen Bond

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Keywords

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