The Halogen Bond

Gabriella Cavallo, Pierangelo Metrangolo (Corresponding Author), Roberto Milani, Tullio Pilati, Arri Priimagi, Giuseppe Resnati (Corresponding Author), Giancarlo Terraneo

    Research output: Contribution to journalArticleScientificpeer-review

    984 Citations (Scopus)

    Abstract

    The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.
    Original languageEnglish
    Pages (from-to)2478-2601
    JournalChemical Reviews
    Volume116
    Issue number4
    DOIs
    Publication statusPublished - 2016
    MoE publication typeA1 Journal article-refereed

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    Halogens
    Materials science
    Atoms
    Pharmaceutical Preparations

    Keywords

    • halogen bond

    Cite this

    Cavallo, G., Metrangolo, P., Milani, R., Pilati, T., Priimagi, A., Resnati, G., & Terraneo, G. (2016). The Halogen Bond. Chemical Reviews, 116(4), 2478-2601. https://doi.org/10.1021/acs.chemrev.5b00484
    Cavallo, Gabriella ; Metrangolo, Pierangelo ; Milani, Roberto ; Pilati, Tullio ; Priimagi, Arri ; Resnati, Giuseppe ; Terraneo, Giancarlo. / The Halogen Bond. In: Chemical Reviews. 2016 ; Vol. 116, No. 4. pp. 2478-2601.
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    Cavallo, G, Metrangolo, P, Milani, R, Pilati, T, Priimagi, A, Resnati, G & Terraneo, G 2016, 'The Halogen Bond', Chemical Reviews, vol. 116, no. 4, pp. 2478-2601. https://doi.org/10.1021/acs.chemrev.5b00484

    The Halogen Bond. / Cavallo, Gabriella; Metrangolo, Pierangelo (Corresponding Author); Milani, Roberto; Pilati, Tullio; Priimagi, Arri; Resnati, Giuseppe (Corresponding Author); Terraneo, Giancarlo.

    In: Chemical Reviews, Vol. 116, No. 4, 2016, p. 2478-2601.

    Research output: Contribution to journalArticleScientificpeer-review

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    AU - Cavallo, Gabriella

    AU - Metrangolo, Pierangelo

    AU - Milani, Roberto

    AU - Pilati, Tullio

    AU - Priimagi, Arri

    AU - Resnati, Giuseppe

    AU - Terraneo, Giancarlo

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    AB - The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.

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    Cavallo G, Metrangolo P, Milani R, Pilati T, Priimagi A, Resnati G et al. The Halogen Bond. Chemical Reviews. 2016;116(4):2478-2601. https://doi.org/10.1021/acs.chemrev.5b00484