Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1-23 |
| Journal | Methods in Enzymology |
| Volume | 542 |
| DOIs | |
| Publication status | Published - 2014 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- ATP
- glucose
- glutamine
- oncometabolism
- tumors
- Warburg effect
- cancer
Cite this
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The metabolic alterations of cancer cells. / Sciacovelli, Marco; Gaude, Edoardo; Hilvo, Mika; Frezza, Christian (Corresponding Author).
In: Methods in Enzymology, Vol. 542, 2014, p. 1-23.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - The metabolic alterations of cancer cells
AU - Sciacovelli, Marco
AU - Gaude, Edoardo
AU - Hilvo, Mika
AU - Frezza, Christian
PY - 2014
Y1 - 2014
N2 - Cancer cells exhibit profound metabolic alterations, allowing them to fulfill the metabolic needs that come with increased proliferation and additional facets of malignancy. Such a metabolic transformation is orchestrated by the genetic changes that drive tumorigenesis, that is, the activation of oncogenes and/or the loss of oncosuppressor genes, and further shaped by environmental cues, such as oxygen concentration and nutrient availability. Understanding this metabolic rewiring is essential to elucidate the fundamental mechanisms of tumorigenesis as well as to find novel, therapeutically exploitable liabilities of malignant cells. Here, we describe key features of the metabolic transformation of cancer cells, which frequently include the switch to aerobic glycolysis, a profound mitochondrial reprogramming, and the deregulation of lipid metabolism, highlighting the notion that these pathways are not independent but rather cooperate to sustain proliferation. Finally, we hypothesize that only those genetic defects that effectively support anabolism are selected in the course of tumor progression, implying that cancer-associated mutations may undergo a metabolically convergent evolution.
AB - Cancer cells exhibit profound metabolic alterations, allowing them to fulfill the metabolic needs that come with increased proliferation and additional facets of malignancy. Such a metabolic transformation is orchestrated by the genetic changes that drive tumorigenesis, that is, the activation of oncogenes and/or the loss of oncosuppressor genes, and further shaped by environmental cues, such as oxygen concentration and nutrient availability. Understanding this metabolic rewiring is essential to elucidate the fundamental mechanisms of tumorigenesis as well as to find novel, therapeutically exploitable liabilities of malignant cells. Here, we describe key features of the metabolic transformation of cancer cells, which frequently include the switch to aerobic glycolysis, a profound mitochondrial reprogramming, and the deregulation of lipid metabolism, highlighting the notion that these pathways are not independent but rather cooperate to sustain proliferation. Finally, we hypothesize that only those genetic defects that effectively support anabolism are selected in the course of tumor progression, implying that cancer-associated mutations may undergo a metabolically convergent evolution.
KW - ATP
KW - glucose
KW - glutamine
KW - oncometabolism
KW - tumors
KW - Warburg effect
KW - cancer
U2 - 10.1016/B978-0-12-416618-9.00001-7
DO - 10.1016/B978-0-12-416618-9.00001-7
M3 - Article
VL - 542
SP - 1
EP - 23
JO - Methods in Enzymology
JF - Methods in Enzymology
SN - 0076-6879
ER -